Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Kraitsy, K; Uecal, M; Grossauer, S; Bruckmann, L; Pfleger, F; Ropele, S; Fazekas, F; Gruenbacher, G; Patz, S; Absenger, M; Porubsky, C; Smolle-Juettner, F; Tezer, I; Molcanyi, M; Fasching, U; Schaefer, U.
Repetitive long-term hyperbaric oxygen treatment (HBOT) administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function.
PLoS One. 2014; 9(5):e97750-e97750 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Absenger-Novak Markus
Bruckmann Lukas
Fazekas Franz
Grossauer Stefan
Grünbacher Gerda
Kraitsy Klaus
Molcanyi Marek
Patz Silke
Porubsky Christian
Ropele Stefan
Schäfer Ute
Smolle-Juettner Freyja-Maria
Ücal Muammer
Zefferer Ulrike
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Number of Figures: 6
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Abstract:
Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Brain - pathology
Brain Injuries - pathology
Evoked Potentials -
Hyperbaric Oxygenation -
Male -
Myelin Sheath - physiology
Psychomotor Performance -
Rats -
Rats, Sprague-Dawley -
Recovery of Function -
Time Factors -

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