Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Ropele, S; Kilsdonk, ID; Wattjes, MP; Langkammer, C; de Graaf, WL; Frederiksen, JL; Larsson, HB; Yiannakas, M; Wheeler-Kingshott, CA; Enzinger, C; Khalil, M; Rocca, MA; Sprenger, T; Amann, M; Kappos, L; Filippi, M; Rovira, A; Ciccarelli, O; Barkhof, F; Fazekas, F.
Determinants of iron accumulation in deep grey matter of multiple sclerosis patients.
Mult Scler. 2014; 20(13):1692-1698
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Enzinger Christian
Fazekas Franz
Khalil Michael
Langkammer Christian
Ropele Stefan
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Abstract:
Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping. Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume. Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load. Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner. © The Author(s), 2014.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Brain - metabolism
Brain - pathology
Female -
Gray Matter - metabolism
Gray Matter - pathology
Humans -
Image Interpretation, Computer-Assisted -
Iron - analysis
Male -
Middle Aged -
Multiple Sclerosis - metabolism
Multiple Sclerosis - pathology
Young Adult -

Find related publications in this database (Keywords)
Multiple sclerosis
brain
R-2*
iron
deep grey matter
age
disease duration
Expanded Disability Status Scale
brain volume
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