Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Urbas, R; Mayr, C; Klieser, E; Fuereder, J; Bach, D; Stättner, S; Primavesi, F; Jaeger, T; Stanzer, S; Ress, AL; Löffelberger, M; Wagner, A; Berr, F; Ritter, M; Pichler, M; Neureiter, D; Kiesslich, T.
Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients.
Int J Mol Sci. 2016; 17(12): [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Lembeck Anna Lena
Pichler Martin
Stanzer Stefanie

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Number of Figures: 4
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Extensive stromal interaction is one reason for the dismal outcome of biliary tract cancer (BTC) patients. Epithelial to mesenchymal transition (EMT) is involved in tumor invasion and metastasis and is partly regulated by microRNAs (miRs). This study explores the expression of anti-EMT miR200 family (miR141, -200a/b/c, -429) and miR205 as well as the EMT-related proteins E-cadherin and vimentin in a panel of BTC cell lines and clinical specimens by quantitative real-time polymerase chain reaction, Western blot and immunohistochemistry, respectively. MicroRNA expression was correlated to (i) the expression patterns of E-cadherin and vimentin; (ii) clinicopathological characteristics; and (iii) survival data. MicroRNA-200 family and miR205 were expressed in all BTC cells and clinical specimens. E-cadherin and vimentin showed a mutually exclusive expression pattern in both, in vitro and in vivo. Expression of miR200 family members positively correlated with E-cadherin and negatively with vimentin expression in BTC cells and specimens. High expression of miR200 family members (but not miR205) and E-cadherin was associated with longer survival, while low miR200 family and high vimentin expression was a predictor of unfavorable survival. Overall, the current study demonstrates the relevance of the miR200 family in EMT of BTC tumors and suggests these miRs as predictors for positive outcome.
Find related publications in this database (using NLM MeSH Indexing)
Biliary Tract Neoplasms - genetics
Biliary Tract Neoplasms - pathology
Cell Line, Tumor -
Epithelial-Mesenchymal Transition - genetics
Epithelial-Mesenchymal Transition - physiology
Female -
Gene Expression Regulation, Neoplastic - genetics
Gene Expression Regulation, Neoplastic - physiology
Humans -
MicroRNAs - genetics
RNA, Messenger - genetics

Find related publications in this database (Keywords)
biliary tract cancer
epithelial to mesenchymal transition
microRNA-200 family
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