Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Stanta, G; Jahn, SW; Bonin, S; Hoefler, G.
Tumour heterogeneity: principles and practical consequences.
Virchows Arch. 2016; 469(4):371-384
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Autor/innen der Med Uni Graz:
Hoefler Gerald
Jahn Stephan
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Abstract:
Two major reasons compel us to study tumour heterogeneity: firstly, it represents the basis of acquired therapy resistance, and secondly, it may be one of the major sources of the low level of reproducibility in clinical cancer research. The present review focuses on the heterogeneity of neoplastic disease, both within the primary tumour and between primary tumour and metastases. We discuss different levels of heterogeneity and the current understanding of the phenomenon, as well as imminent developments relevant for clinical research and diagnostic pathology. It is necessary to develop new tools to study heterogeneity and new biomarkers for heterogeneity. Established and new in situ methods will be very useful. In future studies, not only clonal heterogeneity needs to be addressed but also non-clonal phenotypic heterogeneity which might be important for therapy resistance. We also review heterogeneity established in major tumour types, in order to explore potential similarities that might help to define new strategies for targeted therapy.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Cell Plasticity - physiology
Genetic Heterogeneity -
Humans -
Neoplasm Metastasis - diagnosis
Neoplasm Metastasis - pathology
Neoplasms - diagnosis
Neoplasms - metabolism
Neoplasms - therapy
Phenotype -
Reproducibility of Results -

Find related publications in this database (Keywords)
Tumour heterogeneity
Phenotypic
Clonal
Epigenetic
Molecular
Functional plasticity
Intratumour
Intertumour
Spatial
Temporal
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