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SHR Neuro Krebs Kardio Lipid

Healy, ME; Chow, JD; Byrne, FL; Breen, DS; Leitinger, N; Li, C; Lackner, C; Caldwell, SH; Hoehn, KL.
Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.
J Hepatol. 2015; 62(3):599-606 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Lackner Karoline

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Mice exposed to the hepatocellular carcinogen diethylnitrosamine at 2 weeks of age have a high risk of developing primary liver tumors later in life. Previous studies have demonstrated that diethylnitrosamine-treated mice have increased tumor burden when fed an obesigenic "Western" diet rich in lard fat and sugar. However, the role of dietary fats vs. sugars in the promotion of liver cancer is poorly understood. The aim of this study was to determine how altering dietary fats vs. sugars affects tumor burden in the diethylnitrosamine model. C57BL/6N mice were treated with diethylnitrosamine at 2 weeks of age and, from 6 to 32 weeks of age, fed one of five diets that differed in fat and sugar content, including normal chow, ketogenic, and Western diets. Mice fed sugar-rich diets had the greatest tumor burden irrespective of dietary fat content. In contrast, mice fed a high-fat low-sugar diet had the least tumor burden despite obesity and glucose intolerance. When evaluated as independent variables, tumor burden was positively correlated with hepatic fat accumulation, postprandial insulin, and liver IL-6, and inversely correlated with serum adiponectin. In contrast, tumor burden did not correlate with adiposity, fasting insulin, or glucose intolerance. Furthermore, mice fed high sugar diets had lower liver expression of p21 and cleaved caspase-3 compared to mice fed low sugar diets. These data indicate that dietary sugar intake contributes to liver tumor burden independent of excess adiposity or insulin resistance in mice treated with diethylnitrosamine. Copyright © 2014 European Association for the Study of the Liver. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adipokines - blood
Adiposity -
Animals -
Carcinogens - toxicity
Diet, Ketogenic - adverse effects
Diet, Western - adverse effects
Dietary Carbohydrates - administration & dosage
Dietary Carbohydrates - adverse effects
Dietary Fats - administration & dosage
Dietary Fats - adverse effects
Diethylnitrosamine - toxicity
Female -
Inflammation Mediators - metabolism
Insulin Resistance -
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - etiology
Liver Neoplasms, Experimental - pathology
Male -
Mice -
Mice, Inbred C57BL -
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - etiology
Non-alcoholic Fatty Liver Disease - metabolism
Tumor Burden -

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Liver cancer
Insulin resistance
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