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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Suppan, E; Urlesberger, B; Schwaberger, B; Höller, N; Wolfsberger, CH; Avian, A; Pichler, G.
Fetal Hemoglobin and Cerebral Tissue Oxygenation during Immediate Postnatal Transition.
Neonatology. 2022; 119(5):602-610 Doi: 10.1159/000525847
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Führende Autor*innen der Med Uni Graz

Pichler Gerhard

Suppan Ena

Co-Autor*innen der Med Uni Graz

Avian Alexander

Höller Nina

Schwaberger Bernhard Christian

Urlesberger Berndt

Wolfsberger Christina H.

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Abstract:

INTRODUCTION: Concentration of fetal hemoglobin (HbFc) in human neonates determines oxygen-carrying capacity of blood and the position of oxyhemoglobin dissociation curve. Near-infrared spectroscopy enables the measurement of regional cerebral tissue oxygen saturation (rScO2) and in combination with measurements of pulsatile arterial oxygen saturation (SpO2), the calculation of cerebral fractional tissue oxygen extraction (cFTOE). METHODS: We aimed to investigate the impact of HbFc on rScO2, cFTOE, and SpO2 in preterm and term neonates during the first 15 min after birth. Blood analyses provided total blood hemoglobin (Hb) and HbFc measurements. Correlations between HbFc, Hb and rScO2, cFTOE, and SpO2 in each minute were analyzed. RESULTS: Ninety term and 19 preterm neonates without medical support were included. HbFc was significantly higher in preterm neonates, whereas there were no significant differences in Hb between the groups. In preterm neonates, we found positive correlations of both HbFc and Hb with rScO2 and negative correlations of HbFc and Hb with cFTOE in the first minutes after birth. In contrast, there were no significant correlations between the same parameters in term neonates. Correlations between HbFc or Hb and SpO2 were either insignificant, negligible, or very low in both groups. DISCUSSION/CONCLUSION: In preterm neonates, higher HbFc was associated with higher rScO2 and lower cFTOE in the first minutes after birth. This phenomenon could not be confirmed in term neonates and might reflect immature autoregulation of oxygen delivery to the brain or lower oxygen consumption in preterm neonates in the first minutes of immediate postnatal transition.

Find related publications in this database (using NLM MeSH Indexing)

Brain - administration & dosage

Cerebrovascular Circulation - physiology

Fetal Hemoglobin - analysis

Humans - administration & dosage

Infant, Newborn - administration & dosage

Infant, Premature - physiology

Oximetry - administration & dosage

Oxygen - administration & dosage

Oxyhemoglobins - analysis

Find related publications in this database (Keywords)

Neonate

Fetal hemoglobin

Postnatal transition

Near-infrared spectroscopy

Regional cerebral tissue oxygen saturation

Cerebral fractional tissue oxygen extraction

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