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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Smolle, MA; Helmberg, W; Matzhold, EM; Barth, DA; Sareban, N; Szkandera, J; Liegl-Atzwanger, B; Leithner, A; Pichler, M.
Impact of allogeneic red blood cell transfusion on prognosis in soft tissue sarcoma patients. A single-centre study.
Cancer Med. 2023; 12(2):1237-1246 Doi: 10.1002/cam4.4989 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Pichler Martin

Smolle Maria Anna

Co-Autor*innen der Med Uni Graz

Barth Dominik Andreas

Helmberg Wolfgang

Leithner Andreas

Liegl-Atzwanger Bernadette

Matzhold Eva-Maria

Sareban Nazanin

Szkandera Joanna

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Abstract:

BACKGROUND: Perioperatively administered (leukocyte reduced) allogeneic red blood cell transfusions (lrRBCTs) may lead to transfusion-related immunomodulation and reduced overall survival (OS) in cancer patients. Herein, the effect of lrRBCT on local recurrence (LR), distant metastasis (DM), and OS in soft tissue sarcoma (STS) patients was analysed. METHODS: Retrospective study on 432 STS patients (mean age: 60.0 ± 17.8 years; 46.1% female), surgically treated at a tertiary tumour centre. Uni- and multivariate survival models were calculated to analyse impact of perioperative lrRBCTs on LR, DM, OS. RESULTS: Perioperatively, 75 patients (17.4%) had received lrRBCTs. Older patients, deep, large, lower limb STS rather required lrRBCTs (all p < 0.05). No significant association between lrRBCT administration and LR- (p = 0.582) or DM-risk (p = 0.084) was observed. LrRBCT was associated with worse OS in univariate analysis (HR: 2.222; p < 0.001), with statistical significance lost upon multivariate analysis (HR: 1.658; p = 0.059; including age, histology, size, grading, amputation, depth). Adding preoperative haemoglobin in subgroup of 220 patients with laboratory parameters revealed significant negative impact of low haemoglobin on OS (p = 0.014), whilst effect of lrRBCT was further diminished (p = 0.167). CONCLUSION: Unfavourable prognostic factors prevail in STS patients requiring lrRBCTs. Low haemoglobin levels rather than lrRBCT seem to reduce OS.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Female - administration & dosage

Adult - administration & dosage

Middle Aged - administration & dosage

Aged - administration & dosage

Male - administration & dosage

Erythrocyte Transfusion - adverse effects

Retrospective Studies - administration & dosage

Prognosis - administration & dosage

Sarcoma - pathology

Soft Tissue Neoplasms - therapy

Hematopoietic Stem Cell Transplantation - administration & dosage

Neoplasm Recurrence, Local - pathology

Find related publications in this database (Keywords)

prognosis

soft tissue sarcoma

surgery

surgical oncology

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