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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Malle, O; Bergthaler, M; Krisper, P; Amrein, K; Dimai, HP; Kirsch, AH; Rosenkranz, AR; Pieber, T; Obermayer-Pietsch, B; Fahrleitner-Pammer, A.
Usefulness of the trabecular bone score in maintenance dialysis patients : A single center observational study.
Wien Klin Wochenschr. 2022; 134(11-12):442-448 Doi: 10.1007/s00508-022-02011-4 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Malle Oliver

Co-Autor*innen der Med Uni Graz

Amrein Karin

Bergthaler Markus

Dimai Hans Peter

Fahrleitner-Pammer Astrid

Kirsch Alexander

Krisper Peter

Obermayer-Pietsch Barbara

Pieber Thomas

Rosenkranz Alexander

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Abstract:

BACKGROUND: The number of dialysis patients is steadily increasing. Associated comorbidities include impaired bone and mineral metabolism, termed chronic kidney disease-mineral and bone disorder (CKD-MBD), leading to a high fracture risk, increased morbidity and mortality and impaired quality of life. While the bone density is assessed with dual-energy X‑ray absorptiometry (DXA), the trabecular bone score (TBS) captures the image texture as a potential index of skeletal microarchitecture. The aim of this study was to evaluate the clinical relevance of DXA and TBS in dialysis patients with and without prevalent fractures. METHODS: Bone disorders were evaluated in 82 dialysis patients (37% female) at the University Hospital of Graz, Austria, by DXA including the assessment of the TBS based on a patient interview and the local routine patient database software. The patient cohort was stratified by having sustained a fragility fracture in the past or not. Descriptive statistics, t‑tests for continuous variables and χ²-tests for nominal variables including results of DXA and TBS were performed to compare these groups considering the dialysis modality and duration as well as the number of kidney transplantations. RESULTS: Of the 82 patients, 32 (39%) had a positive history of fractures. There was a significant association between dialysis duration and fracture prevalence (p < 0.05) as well as musculoskeletal pain (p < 0.01). No significant correlation between DXA/TBS parameters and musculoskeletal pain could be established. The DXA scores did not correlate with fracture prevalence with the exception of DXA radius measurements; however, fracture prevalence significantly correlated inversely with TBS (p < 0.001). CONCLUSION: The use of DXA has a limited role in fracture prediction in dialysis patients; however, the TBS seems to add information as an additional tool for fracture risk estimation in this patient population.

Find related publications in this database (using NLM MeSH Indexing)

Absorptiometry, Photon - methods

Bone Density - administration & dosage

Cancellous Bone - diagnostic imaging

Female - administration & dosage

Humans - administration & dosage

Lumbar Vertebrae - administration & dosage

Male - administration & dosage

Musculoskeletal Pain - administration & dosage

Osteoporotic Fractures - administration & dosage

Quality of Life - administration & dosage

Renal Dialysis - administration & dosage

Find related publications in this database (Keywords)

Osteoporosis

Chronic kidney disease

Mineral and bone disorder

Bone imaging

Bone microarchitecture

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