Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Malle, O; Bergthaler, M; Krisper, P; Amrein, K; Dimai, HP; Kirsch, AH; Rosenkranz, AR; Pieber, T; Obermayer-Pietsch, B; Fahrleitner-Pammer, A.
Usefulness of the trabecular bone score in maintenance dialysis patients : A single center observational study.
Wien Klin Wochenschr. 2022; 134(11-12):442-448 Doi: 10.1007/s00508-022-02011-4 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Malle Oliver
Co-Autor*innen der Med Uni Graz
Amrein Karin
Bergthaler Markus
Dimai Hans Peter
Fahrleitner-Pammer Astrid
Kirsch Alexander
Krisper Peter
Obermayer-Pietsch Barbara
Pieber Thomas
Rosenkranz Alexander

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BACKGROUND: The number of dialysis patients is steadily increasing. Associated comorbidities include impaired bone and mineral metabolism, termed chronic kidney disease-mineral and bone disorder (CKD-MBD), leading to a high fracture risk, increased morbidity and mortality and impaired quality of life. While the bone density is assessed with dual-energy X‑ray absorptiometry (DXA), the trabecular bone score (TBS) captures the image texture as a potential index of skeletal microarchitecture. The aim of this study was to evaluate the clinical relevance of DXA and TBS in dialysis patients with and without prevalent fractures. METHODS: Bone disorders were evaluated in 82 dialysis patients (37% female) at the University Hospital of Graz, Austria, by DXA including the assessment of the TBS based on a patient interview and the local routine patient database software. The patient cohort was stratified by having sustained a fragility fracture in the past or not. Descriptive statistics, t‑tests for continuous variables and χ2-tests for nominal variables including results of DXA and TBS were performed to compare these groups considering the dialysis modality and duration as well as the number of kidney transplantations. RESULTS: Of the 82 patients, 32 (39%) had a positive history of fractures. There was a significant association between dialysis duration and fracture prevalence (p < 0.05) as well as musculoskeletal pain (p < 0.01). No significant correlation between DXA/TBS parameters and musculoskeletal pain could be established. The DXA scores did not correlate with fracture prevalence with the exception of DXA radius measurements; however, fracture prevalence significantly correlated inversely with TBS (p < 0.001). CONCLUSION: The use of DXA has a limited role in fracture prediction in dialysis patients; however, the TBS seems to add information as an additional tool for fracture risk estimation in this patient population.
Find related publications in this database (using NLM MeSH Indexing)
Absorptiometry, Photon - methods
Bone Density - administration & dosage
Cancellous Bone - diagnostic imaging
Female - administration & dosage
Humans - administration & dosage
Lumbar Vertebrae - administration & dosage
Male - administration & dosage
Musculoskeletal Pain - administration & dosage
Osteoporotic Fractures - administration & dosage
Quality of Life - administration & dosage
Renal Dialysis - administration & dosage

Find related publications in this database (Keywords)
Chronic kidney disease
Mineral and bone disorder
Bone imaging
Bone microarchitecture
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