Gewählte Publikation:

Pakisch, B; Langmann, G; Langmann, A; Slavc, I; Poier, E; Urban, C; Poschauko, J; Lackner, H; Knoblauch, S; Leitner, H.
Ocular sequelae of multimodal therapy of hematologic malignancies in children.
Med Pediatr Oncol. 1994; 23(4):344-349 Doi: 10.1002/mpo.2950230405
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Co-Autor*innen der Med Uni Graz

Dornbusch Hans Jürgen

Hackl Arnulf

Lackner Herwig

Langmann Andrea

Langmann Gerald

Raith Johann

Urban Ernst-Christian

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Abstract:

We retrospectively analyzed the ocular findings after polychemotherapy including intrathecal methotrexate, systemic corticosteroids, and prophylactic cranial irradiation in children with acute lymphoblastic leukemia (n = 16) and non-Hodgkin's lymphoma (n = 2). After a median surveillance time of 4.1 years, asymptomatic ocular abnormalities were observed in 83% of the patients: 7/18 had a decreased tear formation, 5/17 had an opacity of the vitreous body, and 13/18 had an opacity of the lens. It was not possible to determine retrospectively which therapy caused a particular effect. A comparison of the 2 irradiation techniques (with and without blocking of the lacrimal glands) showed that in 5/7 children who developed a reduced eye secretion, the lacrimal glands are within the treatment volume. Therefore, the reduced eye secretion is most likely radiation-induced. Whereas the opacities of the vitreous body were caused by thrombopenia and bleeding during the course of disease, corticoid therapy might have contributed to the lens opacities.

Find related publications in this database (using NLM MeSH Indexing)

Adolescent -

Antineoplastic Agents - adverse effects

Cataract - etiology

Child - etiology

Child, Preschool - etiology

Combined Modality Therapy - adverse effects

Cranial Irradiation - adverse effects

Eye Diseases - etiology

Female - etiology

Glucocorticoids - adverse effects

Humans - adverse effects

Leukemia, Lymphocytic, Acute, L1 - therapy

Lymphoma, Non-Hodgkin - therapy

Male - therapy

Retrospective Studies - therapy

Vision Disorders - etiology

Find related publications in this database (Keywords)

Non-Hodgkins Lymphoma

Acute Lymphoblastic Leukemia

Polychemotherapy

Glucocorticoid Therapy

Prophylactic Cranial Irradiation

Lens Opacities

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