Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

Pakisch, B; Langmann, G; Langmann, A; Slavc, I; Poier, E; Urban, C; Poschauko, J; Lackner, H; Knoblauch, S; Leitner, H.
Ocular sequelae of multimodal therapy of hematologic malignancies in children.
Med Pediatr Oncol. 1994; 23(4):344-349 Doi: 10.1002/mpo.2950230405
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Co-Autor*innen der Med Uni Graz
Dornbusch Hans Jürgen
Hackl Arnulf
Lackner Herwig
Langmann Andrea
Langmann Gerald
Raith Johann
Urban Ernst-Christian

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We retrospectively analyzed the ocular findings after polychemotherapy including intrathecal methotrexate, systemic corticosteroids, and prophylactic cranial irradiation in children with acute lymphoblastic leukemia (n = 16) and non-Hodgkin's lymphoma (n = 2). After a median surveillance time of 4.1 years, asymptomatic ocular abnormalities were observed in 83% of the patients: 7/18 had a decreased tear formation, 5/17 had an opacity of the vitreous body, and 13/18 had an opacity of the lens. It was not possible to determine retrospectively which therapy caused a particular effect. A comparison of the 2 irradiation techniques (with and without blocking of the lacrimal glands) showed that in 5/7 children who developed a reduced eye secretion, the lacrimal glands are within the treatment volume. Therefore, the reduced eye secretion is most likely radiation-induced. Whereas the opacities of the vitreous body were caused by thrombopenia and bleeding during the course of disease, corticoid therapy might have contributed to the lens opacities.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Antineoplastic Agents - adverse effects
Cataract - etiology
Child - etiology
Child, Preschool - etiology
Combined Modality Therapy - adverse effects
Cranial Irradiation - adverse effects
Eye Diseases - etiology
Female - etiology
Glucocorticoids - adverse effects
Humans - adverse effects
Leukemia, Lymphocytic, Acute, L1 - therapy
Lymphoma, Non-Hodgkin - therapy
Male - therapy
Retrospective Studies - therapy
Vision Disorders - etiology

Find related publications in this database (Keywords)
Non-Hodgkins Lymphoma
Acute Lymphoblastic Leukemia
Glucocorticoid Therapy
Prophylactic Cranial Irradiation
Lens Opacities
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