Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Kvietkauskas, M; Zitkute, V; Leber, B; Strupas, K; Stiegler, P; Schemmer, P.
The role of melatonin in colorectal cancer treatment: a comprehensive review.
Ther Adv Med Oncol. 2020; 12(9):1758835920931714-1758835920931714 Doi: 10.1177/1758835920931714 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Stiegler Philipp
Co-Autor*innen der Med Uni Graz
Leber Bettina
Schemmer Peter

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Colorectal cancer (CRC) is one of the most common types of cancer worldwide, known as the second leading cause of cancer-related deaths annually. Currently, multimodal treatment strategies, including surgical resection, combined with chemotherapy and radiotherapy, have been used as conventional treatments in patients with CRC. However, clinical outcome of advanced stage disease remains relatively discouraging, due mainly to appearance of CRC chemoresistance, toxicity, and other detrimental side effects. New strategies to overcome these limitations are essential. During the last decades, melatonin (MLT) has been shown to be a potent antiproliferative, anti-metastatic agent with cytotoxic effects on different types of human malignancies, including CRC. Hence, this comprehensive review compiles the available experimental and clinical data analyzing the effects of MLT treatment in CRC patients and its underlying molecular mechanisms. © The Author(s), 2020.

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