Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Platzer, M; Fellendorf, FT; Bengesser, SA; Birner, A; Dalkner, N; Hamm, C; Hartleb, R; Queissner, R; Pilz, R; Rieger, A; Maget, A; Mangge, H; Zelzer, S; Reininghaus, B; Kapfhammer, HP; Reininghaus, EZ.
Adiponectin is decreased in bipolar depression.
World J Biol Psychiatry. 2019; 20(10):813-820 Doi: 10.1080/15622975.2018.1500033
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Fellendorf Frederike
Platzer Martina
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Birner Armin
Dalkner Nina
Hamm Carlo
Hartleb Riccarda
Kapfhammer Hans-Peter
Maget Alexander
Mangge Harald
Pilz Rene
Queissner Robert
Reininghaus Bernd
Reininghaus Eva
Rieger Alexandra
Zelzer Sieglinde

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Objectives: Bipolar disorder (BD) is often accompanied by medical comorbidities, which affect illness course and prognosis. Adipokines may not only be involved in the aetiopathogenetic mechanisms of these comorbidities; there might be an association between adipokines and the neuropsychiatric core features of BD such as mood disturbances and cognitive deficits.Methods: In this investigation, fasting blood samples from 120 individuals with BD (75 euthymic and 45 with mild depressive symptoms) and 68 control subjects were taken and adiponectin and leptin concentrations were analysed.Results: We found that, in female participants, adiponectin levels differed significantly between patients and controls indicating lower levels in individuals with BD, even after controlling for BMI (F(1,92) = 4.65, P = 0.034, partial η2 = 0.05). After stratification by mood status we found a significant difference in adiponectin between controls, euthymic and depressive patients (F(2, 180) = 4.90, P = 0.008, partial η2 = 0.05).Conclusions: This investigation confirms previous findings of an association between low adiponectin levels and depressive state in individuals with BD. Beyond its immediate effect on central nervous system function, adiponectin might interfere with pathophysiological mechanisms of BD and its somatic comorbidities via involvement in metabolic and inflammatory processes.
Find related publications in this database (using NLM MeSH Indexing)
Adiponectin - blood
Adult - administration & dosage
Bipolar Disorder - blood, physiopathology
Case-Control Studies - administration & dosage
Comorbidity - administration & dosage
Disease Progression - administration & dosage
Female - administration & dosage
Humans - administration & dosage
Leptin - blood
Male - administration & dosage
Middle Aged - administration & dosage
Obesity - blood

Find related publications in this database (Keywords)
Bipolar disorder
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