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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Platzer, M; Fellendorf, FT; Bengesser, SA; Birner, A; Dalkner, N; Hamm, C; Hartleb, R; Queissner, R; Pilz, R; Rieger, A; Maget, A; Mangge, H; Zelzer, S; Reininghaus, B; Kapfhammer, HP; Reininghaus, EZ.
Adiponectin is decreased in bipolar depression.
World J Biol Psychiatry. 2019; 20(10):813-820 Doi: 10.1080/15622975.2018.1500033
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Führende Autor*innen der Med Uni Graz

Fellendorf Frederike

Platzer Martina

Co-Autor*innen der Med Uni Graz

Bengesser Susanne

Birner Armin

Dalkner Nina

Hamm Carlo

Hartleb Riccarda

Kapfhammer Hans-Peter

Maget Alexander

Mangge Harald

Pilz Rene

Queissner Robert

Reininghaus Bernd

Reininghaus Eva

Rieger Alexandra

Zelzer Sieglinde

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Abstract:

Objectives: Bipolar disorder (BD) is often accompanied by medical comorbidities, which affect illness course and prognosis. Adipokines may not only be involved in the aetiopathogenetic mechanisms of these comorbidities; there might be an association between adipokines and the neuropsychiatric core features of BD such as mood disturbances and cognitive deficits.Methods: In this investigation, fasting blood samples from 120 individuals with BD (75 euthymic and 45 with mild depressive symptoms) and 68 control subjects were taken and adiponectin and leptin concentrations were analysed.Results: We found that, in female participants, adiponectin levels differed significantly between patients and controls indicating lower levels in individuals with BD, even after controlling for BMI (F(1,92) = 4.65, P = 0.034, partial η² = 0.05). After stratification by mood status we found a significant difference in adiponectin between controls, euthymic and depressive patients (F(2, 180) = 4.90, P = 0.008, partial η² = 0.05).Conclusions: This investigation confirms previous findings of an association between low adiponectin levels and depressive state in individuals with BD. Beyond its immediate effect on central nervous system function, adiponectin might interfere with pathophysiological mechanisms of BD and its somatic comorbidities via involvement in metabolic and inflammatory processes.

Find related publications in this database (using NLM MeSH Indexing)

Adiponectin - blood

Adult - administration & dosage

Bipolar Disorder - blood, physiopathology

Case-Control Studies - administration & dosage

Comorbidity - administration & dosage

Disease Progression - administration & dosage

Female - administration & dosage

Humans - administration & dosage

Leptin - blood

Male - administration & dosage

Middle Aged - administration & dosage

Obesity - blood

Find related publications in this database (Keywords)

Bipolar disorder

adipokines

adiponectin

leptin

obesity

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