Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Stadlbauer, V; Horvath, A; Ribitsch, W; Schmerböck, B; Schilcher, G; Lemesch, S; Stiegler, P; Rosenkranz, AR; Fickert, P; Leber, B.
Structural and functional differences in gut microbiome composition in patients undergoing haemodialysis or peritoneal dialysis.
Sci Rep. 2017; 7(1):15601-15601 Doi: 10.1038/s41598-017-15650-9 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Horvath Angela
Stadlbauer-Köllner Vanessa
Co-Autor*innen der Med Uni Graz
Fickert Peter
Leber Bettina
Lemesch Sandra
Ribitsch Werner
Rosenkranz Alexander
Schilcher Gernot
Stiegler Philipp

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Complications of end-stage renal disease (ESRD) are critically related to inflammation. The gut microbiome is a key driver of inflammation. Since dialysis modalities may differently influence the gut microbiome, we aimed to compare the effects of haemodialysis (HD) and peritoneal dialysis (PD) on patients' gut microbiome composition and function. We therefore studied faecal microbiome composition and function as well as inflammation and gut permeability in 30 patients with ESRD (15 HD, 15 PD) and compared to 21 healthy controls. We found an increase in potentially pathogenic species and a decrease in beneficial species in patients on HD and to a lesser extend in patients on PD when compared to controls. These changes in taxonomic composition also resulted in differences in predicted metagenome functions of the faecal microbiome. In HD but not in PD, changes in microbiome composition were associated with an increase in c-reactive protein (CRP) but not with intestinal inflammation or gut permeability. In conclusion microbiome composition in ESRD differs from healthy controls but also between modes of dialysis. These differences are associated with systemic inflammation and cannot completely be explained by dialysis vintage. The mode of renal replacement therapy seems to be an important driver of dysbiosis in ESRD.

© Med Uni Graz Impressum