Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wang, JY; Chen, R; Chen, SP; Gao, YH; Zhang, JL; Feng, XM; Yan, Y; Liu, JL; Gaischek, I; Litscher, D; Wang, L; Lippe, IT; Litscher, G.
Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats.
Neural Plast. 2016; 2016(51):6521026-6521026 Doi: 10.1155/2016/6521026 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Litscher Gerhard
Co-Autor*innen der Med Uni Graz
Gaischek Ingrid
Lippe Irmgard
Litscher Daniela
Wang Lu

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To study the effects of acupuncture analgesia on the hippocampus, we observed the effects of electroacupuncture (EA) and mitogen-activated protein kinase (MEK) inhibitor on pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal area CA1 of sham or chronic constrictive injury (CCI) rats. The animals were randomly divided into a control, a CCI, and a U0126 (MEK1/2 inhibitor) group. In all experiments, we briefly (10-second duration) stimulated the sciatic nerve electrically and recorded the firing rates of PENs and PINs. The results showed that in both sham and CCI rats brief sciatic nerve stimulation significantly increased the electrical activity of PENs and markedly decreased the electrical activity of PINs. These effects were significantly greater in CCI rats compared to sham rats. EA treatment reduced the effects of the noxious stimulus on PENs and PINs in both sham and CCI rats. The effects of EA treatment could be inhibited by U0126 in sham-operated rats. The results suggest that EA reduces effects of acute sciatic nerve stimulation on PENs and PINs in the CA1 region of the hippocampus of both sham and CCI rats and that the ERK (extracellular regulated kinase) signaling pathway is involved in the modulation of EA analgesia.
Find related publications in this database (using NLM MeSH Indexing)
Acupuncture Analgesia - methods
Animals -
Disease Models, Animal -
Electroacupuncture - methods
Hippocampus - metabolism
Male -
Mitogen-Activated Protein Kinases - metabolism
Neuralgia - metabolism
Neuralgia - therapy
Neurons - metabolism
Rats, Wistar -
Sciatic Nerve - injuries
Sciatic Nerve - physiopathology
Sciatic Neuropathy - metabolism
Sciatic Neuropathy - physiopathology

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