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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bengesser, SA; Reininghaus, EZ; Lackner, N; Birner, A; Fellendorf, FT; Platzer, M; Kainzbauer, N; Tropper, B; Hörmanseder, C; Queissner, R; Kapfhammer, HP; Wallner-Liebmann, SJ; Fuchs, R; Petek, E; Windpassinger, C; Schnalzenberger, M; Reininghaus, B; Evert, B; Waha, A.
Is the molecular clock ticking differently in bipolar disorder? Methylation analysis of the clock gene ARNTL.
World J Biol Psychiatry. 2018; 19(sup2):S21-S29 Doi: 10.1080/15622975.2016.1231421
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Führende Autor*innen der Med Uni Graz

Bengesser Susanne

Reininghaus Eva

Co-Autor*innen der Med Uni Graz

Birner Armin

Dalkner Nina

Fuchs Robert

Holasek Sandra Johanna

Kainzbauer Nora

Kapfhammer Hans-Peter

Petek Erwin

Platzer Martina

Queissner Robert

Reininghaus Bernd

Windpassinger Christian

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Abstract:

OBJECTIVES: The clock gene ARNTL is associated with the transcription activation of monoamine oxidase A according to previous literature. Thus, we hypothesised that methylation of ARNTL may differ between bipolar disorder (BD) and controls. METHODS: The methylation status of one CpG island covering the first exon of ARNTL (PS2) and one site in the 5' region of ARNTL (cg05733463) were analysed in patients with BD (n = 151) versus controls (n = 66). Methylation analysis was performed by bisulphite-conversion of DNA from fasting blood with the EpiTect Bisulfite Kit, PCR and pyrosequencing. Analysis of covariances considering the covariates age, body mass index, sex, smoking, lithium and anticonvulsant intake were performed to test methylation differences between BD and controls. RESULTS: Methylation at cg05733463 of ARNTL was significantly higher in BD than in controls (F(1,209) = 44.500, P < .001). In contrast, methylation was significantly lower in BD at PS2_POS1 compared to controls (F(1,128) = 5.787, P = .018) and by trend at PS2_POS2 (F(1,128) = 3.033, P = .084) and POS7 (F(1,34) = 3.425, P = .073). CONCLUSIONS: Methylation of ARNTL differed significantly between BD and controls. Thus, our study suggests that altered epigenetic regulation of ARNTL might provide a mechanistic basis for better understanding circadian rhythms and mood swings in BD.

Find related publications in this database (using NLM MeSH Indexing)

ARNTL Transcription Factors - genetics

Adolescent - administration & dosage

Adult - administration & dosage

Aged - administration & dosage

Aged, 80 and over - administration & dosage

Anticonvulsants - therapeutic use

Austria - administration & dosage

Bipolar Disorder - drug therapy, genetics

Case-Control Studies - administration & dosage

Circadian Rhythm - genetics

CpG Islands - administration & dosage

DNA Methylation - administration & dosage

Epigenesis, Genetic - administration & dosage

Female - administration & dosage

Genetic Predisposition to Disease - administration & dosage

Humans - administration & dosage

Lithium - therapeutic use

Male - administration & dosage

Middle Aged - administration & dosage

Polymorphism, Single Nucleotide - administration & dosage

Young Adult - administration & dosage

Find related publications in this database (Keywords)

Bipolar affective disorder

methylation

ARNTL

cg05733463

PS2

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