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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Horvath, A; Leber, B; Schmerboeck, B; Tawdrous, M; Zettel, G; Hartl, A; Madl, T; Stryeck, S; Fuchs, D; Lemesch, S; Douschan, P; Krones, E; Spindelboeck, W; Durchschein, F; Rainer, F; Zollner, G; Stauber, RE; Fickert, P; Stiegler, P; Stadlbauer, V.
Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis.
Aliment Pharmacol Ther. 2016; 44(9):926-935 Doi: 10.1111/apt.13788 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Horvath Angela

Leber Bettina

Co-Autor*innen der Med Uni Graz

Baumann-Durchschein Franziska

Douschan Philipp

Fickert Peter

Lemesch Sandra

Madl Tobias

Rainer Florian

Spindelböck Walter Johann

Stadlbauer-Köllner Vanessa

Stauber Rudolf

Stiegler Philipp

Stryeck Sarah

Tatscher Elisabeth

Tawdrous Monika

Zettel Gabriele

Zollner Gernot

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Abstract:

Probiotics may correct intestinal dysbiosis and proinflammatory conditions in patients with liver cirrhosis. To test the effects of a multispecies probiotic on innate immune function, bacterial translocation and gut permeability. In a randomised, double blind, placebo-controlled study, stable cirrhotic out-patients either received a daily dose of a probiotic powder containing eight different bacterial strains (Ecologic Barrier, Winclove, Amsterdam, The Netherlands) (n = 44) or a placebo (n = 36) for 6 months and were followed up for another 6 months. We found a significant but subclinical increase in neutrophil resting burst (2.6-3.2%, P = 0.0134) and neopterin levels (7.7-8.4 nmol/L, P = 0.001) with probiotics but not with placebo. Probiotic supplementation did not have a significant influence on neutrophil phagocytosis, endotoxin load, gut permeability or inflammatory markers. Ten severe infections occurred in total; one during intervention in the placebo group, and five and four after the intervention has ended in the probiotic and placebo group, respectively. Liver function showed some improvement with probiotics but not with placebo. Probiotic supplementation significantly increased serum neopterin levels and the production of reactive oxygen species by neutrophils. These findings might explain the beneficial effects of probiotics on immune function. Furthermore, probiotic supplementation may be a well-tolerated method to maintain or even improve liver function in stable cirrhosis. However, its influence on gut barrier function and bacterial translocation in cirrhotic patients is minimal. © 2016 The Authors. Alimentary Pharmacology & Therapeutics Published by John Wiley & Sons Ltd.

Find related publications in this database (using NLM MeSH Indexing)

Adult -

Bacterial Translocation - drug effects

Bacterial Translocation - physiology

Dietary Supplements -

Double-Blind Method -

Female -

Gastrointestinal Absorption - drug effects

Gastrointestinal Absorption - physiology

Gram-Negative Bacteria - drug effects

Gram-Negative Bacteria - physiology

Humans -

Immunity, Innate - drug effects

Immunity, Innate - physiology

Liver Cirrhosis - drug therapy

Liver Cirrhosis - immunology

Liver Cirrhosis - microbiology

Male -

Middle Aged -

Permeability - drug effects

Probiotics - administration & dosage

Treatment Outcome -

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