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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Krause, R; Halwachs, B; Thallinger, GG; Klymiuk, I; Gorkiewicz, G; Hoenigl, M; Prattes, J; Valentin, T; Heidrich, K; Buzina, W; Salzer, HJ; Rabensteiner, J; Prüller, F; Raggam, RB; Meinitzer, A; Moissl-Eichinger, C; Högenauer, C; Quehenberger, F; Kashofer, K; Zollner-Schwetz, I.
Characterisation of Candida within the Mycobiome/Microbiome of the Lower Respiratory Tract of ICU Patients.
PLoS One. 2016; 11(5):e0155033-e0155033 Doi: 10.1371/journal.pone.0155033 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Krause Robert

Co-Autor*innen der Med Uni Graz

Buzina Walter

Gorkiewicz Gregor

Halwachs-Wenzl Bettina

Hoegenauer Christoph

Hönigl Martin

Kashofer Karl

Klymiuk Ingeborg

Meinitzer Andreas

Moissl-Eichinger Christine

Prattes Jürgen

Prüller Florian

Quehenberger Franz

Rabensteiner Jasmin

Raggam Reinhard Bernd

Salzer Helmut J. F.

Valentin Thomas

Zollner-Schwetz Ines

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Abstract:

Whether the presence of Candida spp. in lower respiratory tract (LRT) secretions is a marker of underlying disease, intensive care unit (ICU) treatment and antibiotic therapy or contributes to poor clinical outcome is unclear. We investigated healthy controls, patients with proposed risk factors for Candida growth in LRT (antibiotic therapy, ICU treatment with and without antibiotic therapy), ICU patients with pneumonia and antibiotic therapy and candidemic patients (for comparison of truly invasive and colonizing Candida spp.). Fungal patterns were determined by conventional culture based microbiology combined with molecular approaches (next generation sequencing, multilocus sequence typing) for description of fungal and concommitant bacterial microbiota in LRT, and host and fungal biomarkes were investigated. Admission to and treatment on ICUs shifted LRT fungal microbiota to Candida spp. dominated fungal profiles but antibiotic therapy did not. Compared to controls, Candida was part of fungal microbiota in LRT of ICU patients without pneumonia with and without antibiotic therapy (63% and 50% of total fungal genera) and of ICU patients with pneumonia with antibiotic therapy (73%) (p<0.05). No case of invasive candidiasis originating from Candida in the LRT was detected. There was no common bacterial microbiota profile associated or dissociated with Candida spp. in LRT. Colonizing and invasive Candida strains (from candidemic patients) did not match to certain clades withdrawing the presence of a particular pathogenic and invasive clade. The presence of Candida spp. in the LRT rather reflected rapidly occurring LRT dysbiosis driven by ICU related factors than was associated with invasive candidiasis.

Find related publications in this database (using NLM MeSH Indexing)

Aged -

Anti-Bacterial Agents - therapeutic use

Candida - classification

Candida - drug effects

Candida - genetics

Candida - pathogenicity

Candidiasis - diagnosis

Candidiasis - drug therapy

Female -

High-Throughput Nucleotide Sequencing -

Humans -

Intensive Care Units - statistics & numerical data

Male -

Microbiota - physiology

Middle Aged -

Mouth - microbiology

Mycobiome - physiology

Phylogeny -

Pneumonia - drug therapy

Pneumonia - microbiology

Respiratory System - microbiology

Risk Factors -

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