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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Stadlbauer, V; Leber, B; Lemesch, S; Trajanoski, S; Bashir, M; Horvath, A; Tawdrous, M; Stojakovic, T; Fauler, G; Fickert, P; Högenauer, C; Klymiuk, I; Stiegler, P; Lamprecht, M; Pieber, TR; Tripolt, NJ; Sourij, H.
Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study.
PLoS One. 2015; 10(10):e0141399-e0141399 Doi: 10.1371/journal.pone.0141399 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz

Leber Bettina

Stadlbauer-Köllner Vanessa

Trajanoski Slave

Co-Autor*innen der Med Uni Graz

Bashir Mina

Fauler Günter

Fickert Peter

Hoegenauer Christoph

Horvath Angela

Klymiuk Ingeborg

Lemesch Sandra

Pieber Thomas

Sourij Harald

Stiegler Philipp

Stojakovic Tatjana

Tawdrous Monika

Tripolt Norbert

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Abstract:

Metabolic syndrome is associated with disturbances in gut microbiota composition. We aimed to investigate the effect of Lactobacillus casei Shirota (LcS) on gut microbiota composition, gut barrier integrity, intestinal inflammation and serum bile acid profile in metabolic syndrome. In a single-centre, prospective, randomised controlled pilot study, 28 subjects with metabolic syndrome received either LcS for 12 weeks (n = 13) or no LcS (n = 15). Data were compared to healthy controls (n = 16). Gut microbiota composition was characterised from stool using 454 pyrosequencing of 16S rRNA genes. Serum bile acids were quantified by tandem mass spectrometry. Zonulin and calprotectin were measured in serum and stool by ELISA. Bacteroidetes/Firmicutes ratio was significantly higher in healthy controls compared to metabolic syndrome but was not influenced by LcS. LcS supplementation led to enrichment of Parabacteroides. Zonulin and calprotectin were increased in metabolic syndrome stool samples but not influenced by LcS supplementation. Serum bile acids were similar to controls and not influenced by LcS supplementation. Metabolic syndrome is associated with a higher Bacteroidetes/Firmicutes ratio and gut barrier dysfunction but LcS was not able to change this. LcS administration was associated with subtle microbiota changes at genus level. ClinicalTrials.gov NCT01182844.

Find related publications in this database (using NLM MeSH Indexing)

Adult -

Aged -

Bile Acids and Salts - metabolism

Biodiversity -

Biomarkers -

Case-Control Studies -

Female -

Gastrointestinal Microbiome -

Humans -

Intestinal Mucosa - metabolism

Intestinal Mucosa - microbiology

Lactobacillus casei -

Male -

Metabolic Syndrome X - metabolism

Metabolic Syndrome X - microbiology

Middle Aged -

Pilot Projects -

Probiotics - administration & dosage

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