Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Leber, B; Tripolt, NJ; Blattl, D; Eder, M; Wascher, TC; Pieber, TR; Stauber, R; Sourij, H; Oettl, K; Stadlbauer, V.
The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study.
Eur J Clin Nutr. 2012; 66(10):1110-1115 Doi: 10.1038/ejcn.2012.103 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz

Leber Bettina

Sourij Harald

Tripolt Norbert

Co-Autor*innen der Med Uni Graz

Blattl Daniela

Öttl Karl

Pieber Thomas

Stadlbauer-Köllner Vanessa

Stauber Rudolf

Steinberger Michaela

Wascher Thomas

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

Obesity and metabolic disorders are linked to inflammation via gut microbiota and/or gut permeability. Gut-derived endotoxin triggers inflammation leading to metabolic syndrome (MetS) and contributing to oxidative stress. We intended to investigate the effect of Lactobacillus casei Shirota on gut permeability, presence of endotoxin and neutrophil function in MetS. Patients with MetS were randomized to receive 3 × 6.5 × 10⁹ CFU L. casei Shirota (probiotic group) or not for 3 months. Gut permeability was assessed by a differential sugar absorption method and by determination of diaminooxidase serum levels, endotoxin by an adapted limulus amoebocyte lysate assay, neutrophil function and toll-like receptor (TLR) expression by flow cytometry and ELISA was used to detect lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14) levels. Twenty-eight patients and 10 healthy controls were included. Gut permeability was significantly increased in MetS compared with controls but did not differ between patient groups. None of the patients were positive for endotoxin. LBP and sCD14 levels were not significantly different from healthy controls. High-sensitive C-reactive protein and LBP levels slightly but significantly increased after 3 months within the probiotics group. Neutrophil function and TLR expression did not differ from healthy controls or within the patient groups. Gut permeability of MetS patients was increased significantly compared with healthy controls. L. casei Shirota administration in the MetS patients did not have any influence on any parameter tested possibly due to too-short study duration or underdosing of L. casei Shirota.

Find related publications in this database (using NLM MeSH Indexing)

Acute-Phase Proteins -

Adult -

Aged -

Amine Oxidase (Copper-Containing) - blood

Antigens, CD14 - blood

C-Reactive Protein - analysis

Carrier Proteins - blood

Cohort Studies -

Endotoxins - blood

Female -

Humans -

Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology

Lactobacillus casei - growth & development Lactobacillus casei - immunology Lactobacillus casei - metabolism

Male -

Membrane Glycoproteins - blood

Metabolic Syndrome X - diet therapy Metabolic Syndrome X - immunology Metabolic Syndrome X - metabolism Metabolic Syndrome X - microbiology

Middle Aged -

Neutrophils - immunology Neutrophils - metabolism

Permeability -

Pilot Projects -

Probiotics - therapeutic use

Solubility -

Young Adult -

Find related publications in this database (Keywords)

endotoxin

gut permeability

metabolic syndrome

Lactobacillus casei Shirota

© Med Uni Graz • Impressum