Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Leber, B; Spindelboeck, W; Stadlbauer, V.
Infectious complications of acute and chronic liver disease.
Semin Respir Crit Care Med. 2012; 33(1):80-95 Doi: 10.1055/s-0032-1301737 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Leber Bettina
Stadlbauer-Köllner Vanessa
Co-Autor*innen der Med Uni Graz
Spindelböck Walter Johann

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Acute and chronic liver diseases are frequently complicated by infections, which result in increased morbidity and mortality and place an economic burden on health care systems. This review discusses the epidemiology and the impact on prognosis of infections in liver cirrhosis, nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, acute liver failure, and post-liver transplantation. Possible mechanisms for this increased susceptibility are innate immune dysfunction (Kupffer cells, neutrophils, monocytes), genetic predisposition, and intrinsic cellular defects. The causes for innate immune dysfunction may lie in increased gut permeability, the occurrence of endotoxemia, albumin and lipoprotein dysfunction, or toll-like receptor expression. From a clinical viewpoint this article discusses problems in diagnosing infection. Established (vaccination, antibiotic prophylaxis, antiviral prophylaxis, and nutrition) and experimental (probiotic) prophylactic strategies as well as established (antibiotics) and experimental (liver support, albumin, toll-like receptor antagonists) strategies are also reviewed. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Find related publications in this database (using NLM MeSH Indexing)
Anti-Bacterial Agents - therapeutic use
Community-Acquired Infections - complications Community-Acquired Infections - diagnosis Community-Acquired Infections - drug therapy Community-Acquired Infections - prevention & control
Cross Infection - complications Cross Infection - diagnosis Cross Infection - drug therapy Cross Infection - prevention & control
End Stage Liver Disease - complications End Stage Liver Disease - economics End Stage Liver Disease - epidemiology End Stage Liver Disease - immunology
Fatty Liver - complications
Humans -
Liver Cirrhosis - complications Liver Cirrhosis - economics Liver Cirrhosis - epidemiology Liver Cirrhosis - immunology
Liver Failure, Acute - complications Liver Failure, Acute - economics Liver Failure, Acute - epidemiology Liver Failure, Acute - immunology
Liver Transplantation - adverse effects Liver Transplantation - immunology
Liver, Artificial -
Non-alcoholic Fatty Liver Disease -
Prognosis -
Severity of Illness Index -

Find related publications in this database (Keywords)
liver cirrhosis
acute liver failure
immune dysfunction
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