Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Mayrhauser, U; Stiegler, P; Stadlbauer, V; Koestenbauer, S; Leber, B; Konrad, K; Iberer, F; Portugaller, RH; Tscheliessnigg, K.
Effect of hyperthermia on liver cell lines: important findings for thermal therapy in hepatocellular carcinoma.
Anticancer Res. 2011; 31(5):1583-1588
Web of Science PubMed


Führende Autor*innen der Med Uni Graz
Mayrhauser Ursula
Stiegler Philipp
Co-Autor*innen der Med Uni Graz
Iberer Florian
Konrad Katja Alena
Köstenbauer Sonja
Leber Bettina
Portugaller Rupert
Stadlbauer-Köllner Vanessa
Tscheliessnigg Karlheinz

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Plum Analytics:
Background: Hepatocellular carcinoma is the fifth most common malignant tumour, with a high mortality rate. This study aimed to investigate the effect of hyperthermia on HepG2 and LX-1 cell lines to gain more information on thermal treatment of liver tumours. Materials and Methods: The cell lines HepG2, LX-1 and their co-cultures were heated from 55 degrees C to 85 degrees C for different time spans. After heat exposure, metabolic activity was measured immediately, and after 24 h and 48 h using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) (MTS) test to assess how many cells had survived heating. Results: Our results show highly significant differences between the temperature tolerance of HepG2 and LX-1 cells. Alone, HepG2 cells are most sensitive to heat-induced cell death, their sensitivity decreased with rising percentages of LX-1 cells in the co-culture. Conclusion: Our results suggest that the outcome of thermal cancer therapy is dependent on the temperature and the grade of fibrosis in the treated livers.
Find related publications in this database (using NLM MeSH Indexing)
Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy
Coculture Techniques -
Fever -
Hot Temperature - therapeutic use
Humans -
Liver - metabolism
Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - therapy
Tetrazolium Salts - pharmacology
Thiazoles - pharmacology
Tumor Cells, Cultured -

Find related publications in this database (Keywords)
thermal cancer therapy
hepatic stellate cells
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