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Pansy, J; Minkov, M; Dengg, R; Quehenberger, F; Lackner, H; Nebl, A; Sovinz, P; Schwinger, W; Urban, C; Benesch, M.
Evaluating bleeding severity in children with newly diagnosed immune thrombocytopenia: a pilot study.
Klin Padiatr. 2010; 222(6): 374-377. Doi: 10.1055/s-0030-1267150
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Führende Autor*innen der Med Uni Graz

Pansy Jasmin

Co-Autor*innen der Med Uni Graz

Benesch Martin

Dengg Rosmarie

Lackner Herwig

Nebl Andrea Maria

Quehenberger Franz

Ritter-Sovinz Petra

Schwinger Wolfgang

Urban Ernst-Christian

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Abstract:

Background: Childhood immune thrombocytopenia (ITP) is a bleeding disorder characterized by decreased platelet counts. Assessment of the individual bleeding risk during the course of the disease would allow more accurately guiding treatment-related decisions in these patients. Patients and Methods: We conducted a pilot study and prospectively evaluated platelet counts and bleeding signs using an established bleeding (Buchanan) score in 30 patients with newly diagnosed ITP at 3 different time points (at diagnosis [TP1], on day 2-3 [TP2], and on day 5-8 [TP3]) during the first week after diagnosis. 15 patients received immune modulatory therapy. Results: Median platelet counts at the 3 different time points were 13, 19, 32 x 10(9)/L (untreated patients) and 2, 7, 37 x 10(9)/L (treated patients). Corresponding median cumulative bleeding scores were 5, 2, 0 (untreated patients) and 7, 6, 2 (treated patients). Cumulative median bleeding scores and platelet counts were inversely correlated in treated and untreated patients at all 3 time points. Cumulative median bleeding scores significantly decreased in both groups. Conclusions: Bleeding signs in children with newly diagnosed ITP rapidly improve within one week after diagnosis. Serial grading of bleeding severity seems to be useful to comprehensively assess and monitor the individual bleeding risk in these patients, but has to be evaluated and validated in a larger cohort.

Find related publications in this database (using NLM MeSH Indexing)

Adrenal Cortex Hormones - therapeutic use

Child -

Child, Preschool -

Combined Modality Therapy -

Female -

Hemorrhage - diagnosis Hemorrhage - immunology Hemorrhage - therapy

Humans -

Immunization, Passive -

Male -

Pilot Projects -

Platelet Count -

Prospective Studies -

Purpura, Thrombocytopenic, Idiopathic - diagnosis Purpura, Thrombocytopenic, Idiopathic - immunology Purpura, Thrombocytopenic, Idiopathic - therapy

Find related publications in this database (Keywords)

immune thrombocytopenia

bleeding severity

bleeding score

bleeding risk

children

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