Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Szkandera, J; Ploner, F; Bauernhofer, T; Kasparek, AK; Payer, F; Balic, M; Knechtel, G; Gerger, A; Gallè, G; Samonigg, H; Hofmann, G.
Paraneoplastic limbic encephalitis in a patient with extragonadal choriocarcinoma--significance of onconeural antibodies.
Onkologie. 2010; 33(8-9):452-454 Doi: 10.1159/000317269 (- Case Report)
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Führende Autor*innen der Med Uni Graz

Szkandera Joanna

Co-Autor*innen der Med Uni Graz

Absenger Gudrun

Balic Marija

Bauernhofer Thomas

Gerger Armin

Hofmann Guenter

Kasparek Anne-Katrin

Payer Franz

Ploner Ferdinand

Samonigg Hellmut

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Abstract:

Background: Paraneoplastic limbic or brainstem encephalitis is considered to be an autoimmune-mediated disorder of the nervous system associated with different types of cancer including germ cell tumors. Case Report: We report on a 31-year-old patient presenting with eye motility dysfunction, dysarthrophonia, lethargy, depression, slow mentation, disorientation, dysgraphia, and retarded motion sequence. Neurologic tests, brain imaging, and blood chemistry tests failed to determine the cause of the symptoms. Further examinations including ultrasound of the abdomen led to the detection of a retroperitoneal mass. The biopsy of this mass showed fractions of a choriocarcinoma. The patient underwent curative chemotherapy, but although the cancer therapy was successful, the neurologic disorders did not improve. Concurrent examination for anti-Ma2 antibodies in the serum was positive and confirmed the paraneoplastic origin of these symptoms. Conclusions: Patients with symptoms of limbic or brainstem encephalitis, especially young men, should be tested for anti-Ma2 antibodies in the serum to elucidate their origin. The detection of these antibodies supports the diagnosis of a paraneoplastic syndrome, and may lead to the earlier identification of an otherwise hidden extragonadal germ cell tumor.

Find related publications in this database (using NLM MeSH Indexing)

Adult -

Antibodies, Neoplasm - immunology

Antigens, Neoplasm - diagnostic use Antigens, Neoplasm - immunology

Diagnosis, Differential -

Humans -

Limbic Encephalitis - diagnosis Limbic Encephalitis - immunology

Male -

Neoplasms, Gonadal Tissue -

Nerve Tissue Proteins - diagnostic use Nerve Tissue Proteins - immunology

Peritoneal Neoplasms - diagnosis Peritoneal Neoplasms - immunology

Find related publications in this database (Keywords)

Paraneoplastic neurologic syndromes

Limbic encephalitis

Extragonadal germ cell tumor

Choriocarcinoma

Anti-Ma2 antibodies

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