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Koestenbauer, S; Stiegler, P; Stadlbauer, V; Mayrhauser, U; Leber, B; Schweiger, M; Wasler, A; Prenner, G; Sereinigg, M; Zelzer, S; Stojakovic, T; Scarpatetti, M; Griesbacher, A; Greilberger, J; Tscheliessnigg, K.
Myeloperoxidase and carbonyl proteins: promising markers for non-invasive monitoring of graft rejection after heart transplantation.
J Heart Lung Transplant. 2010; 29(12): 1352-1357. Doi: 10.1016/j.healun.2010.05.020
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Führende Autor*innen der Med Uni Graz

Köstenbauer Sonja

Stiegler Philipp

Co-Autor*innen der Med Uni Graz

Greilberger Joachim

Griesbacher Antonia

Leber Bettina

Mayrhauser Ursula

Prenner Günther

Scarpatetti Michael

Schweiger Martin

Sereinigg Michael

Stadlbauer-Köllner Vanessa

Stojakovic Tatjana

Tscheliessnigg Karlheinz

Wasler Andrae

Zelzer Sieglinde

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Abstract:

BACKGROUND After heart transplantation (HTx) endomyocardial biopsy (EMB) is currently the standard method to diagnose acute graft rejection A non-invasive marker of rejection would be desirable as an alternative or to permit more selective use of the costly and invasive EMB METHODS In this retrospective study outcomes of routinely taken EMBs were used to select 28 patients after HTx EMB Grade OR (8 patients) 1R (9 patients) or 2R (11 patients) For these patients, myeloperoxidase (MPO) and carbonyl proteins (CP) in serum were measured using enzyme-linked Immunoassay (ELISA) RESULTS MPO and CP levels in post-HTx patients with Grade 2R rejection were significantly (MPO p < 001 CP p < 0 001) elevated at the time of rejection compared with levels 1 month earlier MPO and CP levels predicted Grade 2R rejection and the best cut-off point was 237 5 mu g/l for MPO and 222 5 pmol/mg for CP respectively Clinically most important was the marked increase (doubling of basic values within 1 month) of MPO and CP levels in cases of Grade 2R rejection in post-HTx patients CONCLUSIONS MPO and CP seem to be appropriate parameters to monitor rejection events non-invasively and to minimize the application of EMBs after HTx J Heart Lung Transplant 2010 29 1352-7 (C) 2010 International Society for Heart and Lung Transplantation All rights reserved

Find related publications in this database (using NLM MeSH Indexing)

Adult -

Aged -

Biological Markers - blood

Biopsy - methods

C-Reactive Protein - analysis

Female -

Graft Rejection - blood

Heart Transplantation -

Humans -

Male -

Middle Aged -

Myocardium - pathology

Natriuretic Peptide, Brain - blood

Peptide Fragments - blood

Peroxidase - blood

Predictive Value of Tests -

Protein Carbonylation -

Retrospective Studies -

Find related publications in this database (Keywords)

myeloperoxidase

carbonyl proteins

non-invasive rejection

monitoring

heart transplantation

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