Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Hoenigl, M; Orasch, T; Faserl, K; Prattes, J; Loeffler, J; Springer, J; Gsaller, F; Reischies, F; Duettmann, W; Raggam, RB; Lindner, H; Haas, H.
Triacetylfusarinine C: A urine biomarker for diagnosis of invasive aspergillosis.
J Infect. 2019; 78(2):150-157 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Düttmann Wiebke
Hönigl Martin
Prattes Jürgen
Raggam Reinhard Bernd
Reischies Frederike Marie Josefine

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Number of Figures: 4
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Early diagnosis of invasive aspergillosis (IA) remains challenging, with available diagnostics being limited by inadequate sensitivities and specificities. Triacetylfusarinine C, a fungal siderophore that has been shown to accumulate in urine in animal models, is a potential new biomarker for diagnosis of IA. We developed a method allowing absolute and matrix-independent mass spectrometric quantification of TAFC. Urine TAFC, normalized to creatinine, was determined in 44 samples from 24 patients with underlying hematologic malignancies and probable, possible or no IA according to current EORTC/MSG criteria and compared to other established biomarkers measured in urine and same-day blood samples. TAFC/creatinine sensitivity, specificity, positive and negative likelihood ratio for probable versus no IA (cut-off ≥ 3) were 0.86, 0.88, 6.86, 0.16 per patient. For the first time, we provide proof for the occurrence of TAFC in human urine. TAFC/creatinine index determination in urine showed promising results for diagnosis of IA offering the advantages of non-invasive sampling. Sensitivity and specificity were similar as reported for GM determination in serum and bronchoalveolar lavage, the gold standard mycological criterion for IA diagnosis. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

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