Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Maisel, F; Smolle, MA; Mollnar, S; Riedl, JM; Barth, DA; Seles, M; Terbuch, A; Rossmann, CH; Eisner, F; Mannweiler, S; Hutterer, G; Zigeuner, R; Pummer, K; Smolle-Jüttner, FM; Lindenmann, J; Stotz, M; Gerger, A; Jost, PJ; Bauernhofer, T; Pichler, M; Posch, F.
Benefit of Metastasectomy in Renal Cell Carcinoma: A Propensity Score Analysis.
Clin Genitourin Cancer. 2022; 20(4):344-353 Doi: 10.1016/j.clgc.2022.03.010
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Maisel Franziska
Posch Florian
Co-Autor*innen der Med Uni Graz
Barth Dominik Andreas
Bauernhofer Thomas
Eisner Florian
Gerger Armin
Hutterer Georg
Jost Philipp
Lindenmann Jörg
Mannweiler Sebastian
Pichler Martin
Pummer Karl
Riedl Jakob
Seles Maximilian
Smolle Maria Anna
Smolle-Juettner Freyja-Maria
Stotz Michael
Terbuch Angelika
Zigeuner Richard

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

INTRODUCTION: To quantify the magnitude of benefit of metastasectomy as compared to medical treatment alone in patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS: We therefore conducted a propensity score analysis of overall survival (OS) in 106 mRCC patients with metachronous metastasis, of whom 36 (34%) were treated with metastasectomy, and 70 (66%) with medical therapy alone. RESULTS: The most frequent metastasectomy procedures were lung resections (n = 13) and craniotomies (n = 6). Median time-to-progression after metastasectomy was 0.7 years (25th-75th percentile: 0.3-2.7). After a median follow-up of 6.2 years and 63 deaths, 5-year OS estimates were 41% and 22% in the metastasectomy and medical therapy group, respectively (log-rank P = .00007; Hazard ratio (HR) = 0.38, 95%CI: 0.21-0.68). Patients undergoing metastasectomy had a significantly higher prevalence of favorable prognostic factors, such as fewer bilateral lung metastases and longer disease-free intervals between nephrectomy and metastasis diagnosis. After propensity score weighting for these differences and adjusting for immortal time bias, the favorable association between metastasectomy and OS became much weaker (HR = 0.62, 95%CI: 0.39-1.00, P = .050). Propensity-score-weighted 5-year OS estimates were 24% and 20% in the metastasectomy and medical therapy group, respectively (log-rank P = .001). In exploratory analyses, the benefit of metastasectomy was confined to patients who achieved complete resection of all known metastases. CONCLUSION: Within the limitations of an observational study, these findings support the concept of metastasectomy being associated with an OS benefit in mRCC patients. Metastasectomies not achieving complete resection of all known lesions are likely without OS benefit.
Find related publications in this database (using NLM MeSH Indexing)
Carcinoma, Renal Cell - administration & dosage
Humans - administration & dosage
Kidney Neoplasms - pathology
Metastasectomy - methods
Nephrectomy - methods
Prognosis - administration & dosage
Propensity Score - administration & dosage
Retrospective Studies - administration & dosage
Survival Rate - administration & dosage

Find related publications in this database (Keywords)
Renal cell carcinoma
Propensity score analysis
© Med Uni Graz Impressum