Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Schmidt, R; Enzinger, C; Ropele, S; Schmidt, H; Fazekas, F.
Subcortical vascular cognitive impairment: similarities and differences with multiple sclerosis.
J NEUROL SCI. 2006; 245(1-2): 3-7. Doi: 10.1016/j.jns.2005.06.018
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Leading authors Med Uni Graz

Schmidt Reinhold

Co-authors Med Uni Graz

Enzinger Christian

Fazekas Franz

Ropele Stefan

Schmidt Helena

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Abstract:

Subcortical vascular cognitive impairment is caused by lacunes and widespread ischemic white matter damage which closely resembles white matter abnormalities seen in multiple sclerosis. Recent evidence suggests that the progression rate of ischemic white matter lesions on MRI is very similar to that observed in multiple sclerosis. Consequently, it has been proposed to use MRI for monitoring disease activity not only in multiple sclerosis but also in vascular dementia trials. There is first evidence from magnetization transfer imaging studies that other than in MS normal appearing white matter is not affected in cerebral small vessel disease. This contrasts the hypothesis that ischemic white matter damage extends far beyond changes visible on conventional MR. The cognitive consequences of both diseases are strikingly similar which is at least partly caused by damage to frontal-subcortical circuits. Involvement of these common functional anatomical structures and their modulatory transmitter systems has now led to common interventional approaches such as the use of cholinesterase inhibitors.

Find related publications in this database (using NLM MeSH Indexing)

Brain Mapping -

Cognition - physiology

Dementia, Vascular - diagnosis

Humans - diagnosis

Magnetic Resonance Imaging - methods

Multiple Sclerosis - diagnosis

Find related publications in this database (Keywords)

vascular dementia

cognition

dementia

MRI

white matter lesions

frontal lobe dysfunction

cholinesterase inhibitors

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