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SHR Neuro Cancer Cardio Lipid Metab Microb

Mörkl, S; Butler, MI; Holl, A; Cryan, JF; Dinan, TG.
Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry.
Curr Nutr Rep. 2020; 9(3):171-182 Doi: 10.1007/s13668-020-00313-5 [OPEN ACCESS]
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Leading authors Med Uni Graz

Leal Garcia Sabrina

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Abstract:

Probiotics are living bacteria, which when ingested in adequate amounts, confer health benefits. Gut microbes are suggested to play a role in many psychiatric disorders and could be a potential therapeutic target. Between the gut and the brain, there is a bi-directional communication pathway called the microbiota-gut-brain axis. The purpose of this review is to examine data from recent interventional studies focusing on probiotics and the gut-brain axis for the treatment of depression, anxiety and schizophrenia. Probiotics are likely to improve depression but not schizophrenia. Regarding anxiety, there is only one trial which showed an effect of a multispecies probiotic. However, determinants like the duration of treatment, dosage and interactions have not been thoroughly investigated and deserve more scientific attention. Microbiome-based therapies such as probiotics could be cautiously recommended for depression to enhance beneficial bacteria in the gut and to improve mood through the gut-brain axis.

Find related publications in this database (using NLM MeSH Indexing)

Animals -

Brain - physiology

Gastrointestinal Microbiome -

Humans -

Mental Disorders - prevention & control

Probiotics -

Find related publications in this database (Keywords)

Probiotics

Microbiota-gut-brain axis

Gut microbiota

Vagal nerve

Psychiatry

Depression

Schizophrenia

Anxiety

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