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Methylation analysis of circulating tumor cells and white blood cells in breast cancer patients
- Abstract
- Identification of circulating tumor cells (CTCs) is increasingly playing an important role in the effective and targeted treatment of breast cancer patients. CTCs are very rare in the blood stream, making their isolation and characterization a major technological challenge. Molecular characterization, such as DNA methylation analysis of CTCs, is important to help extract information about their biology.
We propose to use a novel size-based microfilter to enrich for CTCs and analyze methylation in CTCs, thus evaluating the microfilter platform for its applicability to epigenetically characterize both CTCs and white blood cells from the same patient.
- Project Leader:
- Dandachi Nadia
- Duration:
- 01.09.2013-31.08.2016
- Programme:
- Jubiläumsfonds (ÖNB)
- Type of Research
- applied research
- Staff
- Dandachi N., Project Leader
- Balic M., Co-worker
- Kühberger S., Co-worker
- Moritz J., Co-worker
- Reinisch I., Co-worker
- Benezeder T., Co-worker
- MUG Research Units
- Division of Oncology
- Project partners
-
Department of Pathology, United States (USA)
Contact person: Ram Datar;
- Project results published
- > Multigene methylation analysis of enriched circula... Oncotarget. 2017; 8(54):92483-92496