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LADIS: Leukoaraiosis and Disability

Age Related White Matter Changes (ARWMC) of brain are associated with cognitive, motor and psychopathological disturbances, all related to disability in the elderly. The aim is to evaluate ARWMC as independent determinant of transition to disability in the elderly. Subjects with ARWMC of different severity and no/mild disability will be followed for 3 years, evaluating transition to disability, death, stroke, dementia, depression and progression of ARWMC on repeat MRI. Relative risks of transition and other outcomes will be calculated in the different ARWMC severity groups, adjusting for other determinants of disability in the elderly. Transnational harmonisation of clinical and MRI assessments of ARWMC will be also delivered.
Project Leader:
Fazekas Franz
Fürst-Pluta Aga
EU (FP-5)
Type of Research
applied research
Fazekas F., Project Leader
Petrovic K., Co-worker
Ropele S., Co-worker
MUG Research Units
Division of General Neurology
Project partners
Department of Clinical Neuroscience, Sweden
Helsinki University Central Hospital, Finland
Institute of Clinical Neuroscience/Göteborg, Sweden
Service de Neurochirurgie, Switzerland
Service de Neurologie Hopital Lariboisiere, France
University of Lissabon, Portugal
University of Newcastle upon Tyne, United Kingdom
, Netherlands
Funded by
Europäische Kommission, Rue de la Loi, Brussels, Belgium
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