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Abstract: Age Related White Matter Changes (ARWMC) of brain are associated with cognitive, motor and psychopathological disturbances, all related to disability in the elderly. The aim is to evaluate ARWMC as independent determinant of transition to disability in the elderly. Subjects with ARWMC of different severity and no/mild disability will be followed for 3 years, evaluating transition to disability, death, stroke, dementia, depression and progression of ARWMC on repeat MRI. Relative risks of transition and other outcomes will be calculated in the different ARWMC severity groups, adjusting for other determinants of disability in the elderly. Transnational harmonisation of clinical and MRI assessments of ARWMC will be also delivered.

Staff: Fazekas F., Project Leader; Petrovic K., Co-worker; Ropele S., Co-worker

Project partners: Department of Clinical Neuroscience, Sweden; Helsinki University Central Hospital, Finland; Institute of Clinical Neuroscience/Göteborg, Sweden; Service de Neurochirurgie, Switzerland; Service de Neurologie Hopital Lariboisiere, France; University of Lissabon, Portugal; University of Newcastle upon Tyne, United Kingdom; , Netherlands