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Influence of Resveratrol, Quercetin-dihydrate und Seleno-L-Methoionine an Matrix Metalloproteinases and RANKL Levels in Human Osteoarthritis Rheumatoid Arthritis Synovial Fluids

Abstract
Osteoarthritis (OA) is the most prevalent disorder of the musculoskeletal system and has a very high socioeconomic impact. Current treatments for Osteoarthritis are only symptomatic, because they do not act on the causes of Arthritis and do not stop the progression of the disease. This study is designed to investigate the effect of Resveratrol, Quercetin, and Selenium on special inflammation enzymes and factors in human synovial fluid.
Especially Resveratrol is known as a potent specific inhibitor of inflammation, but its potency has not been tested on human synovial fluid. If the protective potency on Osteoarthritis is similar to the results of animal experiments, it would be an enormous effort. Previous studies indicate that elevated levels of matrix metalloproteinases (MMPs) and receptor activator of nuclear factor NFkB ligand (RANKL) play an important role in cartilage degeneration in OA Rheumatic Arthritis (RA) and Psoriatic Arthritis (PsA) [1, 2].
This study should be undertaken to define a possible influence of Resveratrol compared to other antioxidants like Quercetin and Selenium on synovial fluid and these factors. A close interaction between clinicians and basic scientists is necessary because of the combination of analytical, functional and molecular methods.
Project Leader:
Glehr Mathias
Duration:
01.01.2009-31.12.2009
Type of Research
basic research
Staff
Glehr M., Project Leader
Gruber G., Co-worker
Rinner B., Co-worker
Lohberger B., Co-worker
Moazedi-Fürst F., Co-worker
Walzer S., Co-worker
Windhager R., Co-worker
MUG Research Units
Center for Medical Research (ZMF)
Department of Orthopaedics and Trauma
Division of Rheumatology and Immunology
Funded by
AFOR-Stiftung, Association for Orthopaedic Research, CH-2545 Selzach, Switzerland
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