Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
SHR
Neuro
Krebs
Kardio
Stoffw
Microb
Lipid
MICRO-WEDGE
- Abstract
- Several multicenter clinical trials have provided consistent evidence that implantable defibrillation therapy prolongs patient life. This convincing demonstration of the efficacy of defibrillation has led to a nearly exponential growth, over the last decade, in the number of patients receiving implantable devices. The current wide application of defibrillation raises new concerns regarding the safety and optimization of the therapy. Improved understanding of defibrillation mechanisms is therefore
imperative to the development of better and safer strategies for prevention of sudden cardiac death. Despite the importance of this therapy, understanding of mechanisms by which electric shocks halt life-threatening arrhythmias remains incomplete. While recent experimental advances have provided new characterizations of tissue
responses to shocks, mechanistic inquiry into the success and failure of defibrillation is hampered by the inability of current experimental techniques to resolve, with sufficient accuracy, electrical behavior confined to the depth of the ventricles.
The overall objective of this research is, by employing realistic 3D computer simulations, to bring a new level of understanding of the post-shock events in the heart that lead to the failure of the shock. Current models do not incorporate anatomical microheterogeneities, which could play an important role. Specifically, this project proposes to examine, in bidomain models of cardiac micro-structure, mechanisms underlying the ``isoelectric window", the quiescent period often preceding the first postshock activation following failed shocks. We hypothesize that the isoelectric window arises from small-scale shock-induced polarization, such as polarization of trabeculae and papillary muscle. Understanding the isoelectric window mechanisms could pave the way to new strategies for extending it indefinitely, and thus converting a failed shock into a successful one.
- Schlagworte
- Computerunterstützte Simulation
- Elektro- und biomedizinische Technik
- Kardiologie
- Bidomain Gleichungen
- Computer Modell
- Defibrillation
- Isoelektrisches Fenster
- Kardiale Mikrostruktur
- Projektleitung:
- Plank Gernot
- Laufzeit:
- 18.10.2006-17.01.2009
- Programm:
- EU (FP-6)
- Subprogramm
- Marie Curie (Outgoing International Fellowship)
- EU-Projektinstrument
- Marie Curie
- Art der Forschung
- Grundlagenforschung
- Mitarbeiter*innen
- Plank G., Projektleiter*in
- Hofer E., Projektmitarbeiter*in
- Beteiligte MUG-Organisationseinheiten
- Lehrstuhl für Medizinische Physik und Biophysik
- Projektpartner
-
Johns Hopkins University, Institute of Computational Medicine, Vereinigte Staaten (USA)
Kontaktperson: N. Trayanova; -
Oxford University Computing Laboratory, Computational Biology Group/University of Oxford, Großbritannien
Kontaktperson: D. Gavaghan;
- Gefördert durch
- Europäische Kommission, Rue de la Loi, Brussels, Belgien
- Publizierte Projektergebnisse
- > A novel rule-based algorithm for assigning myocard... Ann Biomed Eng. 2012; 40(10):2243-2254
- > Image-based models of cardiac structure with appli... J Electrocardiol. 2009; 42(2): 157.e1-157.10.
- > Towards predictive modelling of the electrophysiol... Exp Physiol. 2009; 94(5): 563-577.
- > Solving the coupled system improves computational ... IEEE Trans Biomed Eng. 2009; 56(10): 2404-2412.
- > Automatically generated, anatomically accurate mes... IEEE Trans Biomed Eng. 2009; 56(5): 1318-1330.
- > Largescale numerical solution of the cardiac bidom... The European Society of Mathematics in Industry Meeting ; JUN 30 - JUL 4, 2008; London. 2008.
- > Modeling the influence of the VV delay for CRT on ... P SOC PHOTO-OPT INSTRUM ENG. 2008; 6918: G9182-G9182.
- > Magnetic resonance imaging-based three-dimensional... European Society of Cardiology; AUG 30-SEPT 3, 2008; Munich. 2008.
- > Role of Purkinje system in cardiac arrhythmias.... Conf Proc IEEE Eng Med Biol Soc. 2008; 2008(4):149-152
- > Nonlinear filtering for extracting orientation and... . 2008; 260-263.
- > High performance computer simulations of cardiac e... LECT NOTE COMPUT SCI. 2008; 5101: 571-580.
- > From mitochondrial ion channels to arrhythmias in ... Philos Transact A Math Phys Eng Sci. 2008; 366(1879):3381-3409
- > Evaluating intramural virtual electrodes in the my... Biophys J. 2008; 94(5): 1904-1915.
- > Assessing influence of conductivity in heart model... P SOC PHOTO-OPT INSTRUM ENG. 2008; 6916: 91627-91627.
- > Arrhythmogenesis research: A perspective from comp... PROC ANN INT CONF IEEE EMBS. 2007; 406-409.
- > An iterative method for registration of high-resol... . 2007; 572-575.