Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Psycho-Neuro-Immunologie. Einfluss einer psychosozialen Intervention auf T und NK Zellfunktion von Patientinnen mit Mammakarzinom

The autonomic, neuroendocrine, and the immune systems are orchestrated in part to preserve conditions compatible with life. The critical question in immunosurveillance against cancer is whether differences between individuals with regard to immunologic host-defense mechanisms can predict the incidende or progression of cancer. Acute as well as chronic stressors have been associated with reduction of various in vitro measures of immune function. Even acute commonplace stressful events like a final examination scenario for medical students or "the public speaking situation" are associated with transient changes in immunologic parameters (e.g. natural killer(NK) cell number and cytotoxity, T helper/inducer cell number, production of interferon (IFN) gamma by lymphocytes stimulated with Concavalin-A, etc.) along with elevated stress hormone levels and cardiovascular activation compared to controls. The aims of the study are: * Further evaluation of differences in immune parameters of patients with breast cancer compared to their significant others and non related healthy volunteers focusing on differences in the relative number of T and NK cell subpopulations, onset of apoptosis and functional parameters like the kinetics of perforin release of stimulated T and NK cells. *Assessment of hormonal parameters in the three study populations and their correlation to immune parameters as well as psychosocial parameters. * Investigation of the influence of psychosocial intervention on the immune system with special regard to T cell- and NK cell subpopulations, rate of apoptosis and perforin release of these immune cells in patients with operated breast cancer compared to significant others and healthy volunteers.
chronischer Stress
Bauernhofer Thomas
Jubiläumsfonds (ÖNB)
Art der Forschung
Angewandte Forschung
Bauernhofer T., Projektleiter*in
Dandachi N., Projektmitarbeiter*in
Hofmann G., Projektmitarbeiter*in
Beteiligte MUG-Organisationseinheiten
Abteilung Zentrum für Medizinische Forschung (ZMF)
Klinische Abteilung für Onkologie
Universitätsklinik für Innere Medizin - Gemeinsame Einrichtung
Gefördert durch
Österreichische Nationalbank (Jubiläumsfonds), Otto Wagner Platz 3, A-1090 Wien, Österreich
Publizierte Projektergebnisse
> Psychoneuroimmunology: theory and practice- challa... Psycho-Oncology 4th International Conference; MAR 15-17, 2006; Graz, AUSTRIA. 2006.
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