Medizinische Universität Graz - Research portal
-
Univ.-Prof. Priv.-Doz. Mag. Dr.rer.nat. Tobias Madl
- Division of Molecular Biology and Biochemistry
- Head of Research Unit
- Integrative Strukturbiologie
- EMail: tobias.madl(at)medunigraz.at
- Tel: +43/316/385/71972
- http://mbbc.medunigraz.at/
- MEDonline-Visitenkarte
- Externe ID's
- Researcher ID: B-1682-2012
- ORCiD: 0000-0002-9725-5231
Fields of expertise
- Our laboratory is interested in understanding the general mechanisms of how disordered proteins mediate signal transfer via an intricate network of protein interactions and post-translational modifications. We work at the interface of structural biology, biophysics, cell biology and medicine to study the molecular mechanisms of key regulatory processes involved in signaling. Nuclear magnetic resonance (NMR) and biophysical methods are the primary tools employed in our laboratory that allow us to study the structural and dynamical properties of signaling proteins and their interactions under native-like solution conditions. Our efforts focus primarily on the highly conserved Wnt signaling pathway, intersected pathways, and the nuclear import of RNA-binding proteins. Distortions in these pathways lead to a plethora of diseases, including cancers and neurodegenerative disorders, and are linked to ageing. We aim to reveal the molecular mechanisms underlying interactions of disordered proteins to provide insight into the intricate link between their function, regulation and human diseases. We use metabolic phenotyping to obtain systemic insight into the molecular outcome of distortions in signaling pathways in cell-based assays, in vivo model systems and patients. This allows us to bridge the gap between atom and patient and vice versa and to obtain new insights into disease mechanisms and diagnosis. To be able to study large and dynamic biomolecular complexes involved in signal transduction, the Madl group employs and develops an integrated structure determination protocol in which they combine NMR spectroscopy, SAXS/SANS, complementary techniques (i.e. MS, EM, FRET) and modeling strategies which are especially suited to study the structure of large and dynamic biomolecules and biomolecular complexes. Next to molecular dynamics programs widely used in the NMR community, their computational focus is on the integration of novel techniques in the Rosetta de novo structure prediction framework. Several approaches have been developed and applied to challenging biological systems in the last few years.
Statistik Austria, science classification
- Bioinformatics - (102004)
- Chemical biology - (104004)
- Biophysics - (106006)
- Structural biology - (106041)
- Cell biology - (301114)
- Medical biochemistry - (301303)
- Medical molecular biology - (301306)
- Neurosciences - (301400)
- Cancer research - (301904)
- Metabolic diseases - (302078)
- Public health - (303026)
Scientific Expertise
- Integrative Structural Biology
- Cancer Research
- Neurodegeneration
- Metabolomics
- NMR Spectroscopy
- Signal Transduction
- Transcription Factors
- RNA-binding Proteins
- Liquid-liquid Phase Separation
- Post-translational Modifications
Curr. Vitae
| 2022 | Head Research Unit Integrative Structural Biology |
| 2022 | Member of Senate |
| 2021 | Full Professor (§99/4) in Integrative Structural Biology and Metabolomics |
| 2021 | Speaker of the research field Metabolism and Circulation |
| 2021 | Speaker of the international PhD program BioMolStruct (FWF doc.fund) |
| 2019 | Head and coordinator of the Integrative Structural Biology Initiative Graz |
| 2019 | Member of the research promotion committee (FFK) |
| 2018 | Faculty Member Doctoral School Metabolic and Cardiovascular Diseases |
| 2018 | Head and coordinator of the Next Generation BioXray research infrastructure project (FFG) |
| 2018 -2021 | Member of the strategy committee of the Gottfried Schatz Research Center |
| 2016 | Faculty Member PhD Program Molecular Medicine |
| 2016 | Habilitation in Molecular Biology |
| 2016 | Full Member of BioTechMed/Graz |
| 2015 -2021 | Associate Professor |
| 2015 | Associated Member Doctoral School Metabolic and Cardiovascular Diseases |
| 2015 | Visiting Professor, Fujian Institute of Research on the Structure of Matter (FJIRSM), Chinese Academy of Sciences, Xiamen, China |
| 2014 -2016 | Member of the CIPSM excellence cluster at the Technical University Munich, Germany |
| 2013 -2016 | Member of the Junior Scientist Program (Tenure-Track position) at the Helmholtz Center Munich, Germany |
| 2012 -2016 | BioSysNet research group leader & TUM Junior Fellow at the Department of Chemistry at the Technical University Munich, Germany |
| 2012 -2016 | Emmy Noether research group leader at the Institute of Structural Bilogy at the Helmholtz Center Munich, Germany |
| 2010 -2012 | Postdoc in integrative structural biology of signal transduction at the Bijvoet Center for Biomolecular Research at Utrecht University, The Netherlands (APART fellowship of the ÖAW) |
| 2007 -2010 | Postdoc in integrative structural biology of protein-RNA complexes at the Department of Chemistry of the Technical University and at the Institute of Structural Biology at the Helmholtz Center Munich, Germany (Schrödinger Fellowship of the FWF, EMBO-LTF) |
| 2007 -2007 | Postdoc in Structural Biology at the Institute of Chemistry, University of Graz, Austria |
| 2004 -2007 | Doctoral Studies in Chemistry, Institute of Chemistry, University of Graz (DOC Fellowship of the ÖAW) |
| 2001 -2005 | Research Assistant at the Institute of Chemistry, University of Graz |
| 1999 -2000 | Laboratory assistant, “Blocklabor II”, Landeskrankenhaus Graz (hospital), Austria |
| 1998 -2004 | Diploma Studies in Chemistry, Physics, History and Computational Sciences at the University Graz, Austria |
Awards
| 2020 | Outstanding Performer at Medical University of Graz |
| 2017 | Research Price (category digital) of the Styrian Government |
| 2015 | The Research Fellowship for International Young Scientists of the National Natural Science Foundation of China (NSFC) |
| 2015 | President’s International Fellowship of the Chinese Academy of Sciences (CAS) |
| 2012 | APART Fellowship, Austrian Academy of Sciences |
| 2012 | Emmy Noether Fellowship, German Research Foundation |
| 2012 | Science Price, Austrian Chemical Society |
| 2010 | Young Researcher Grant for the Joint EUROMAR 2010 and 17th ISMAR Conference |
| 2008 | EMBO Long Term Fellowship (LTF), EMBO |
| 2008 | PhD Prize, Austrian Chemical Society |
| 2008 | Erwin Schrödinger Fellowship, Austrian Science Fund |
| 2007 | Student Travel Stipend for the 48th ENC Conference, Suraj Manrao Foundation |
| 2006 | Travel Stipend of the Land Steiermark |
| 2005 | DOC Fellowship, Austrian Academy of Sciences |
| 2005 | Travel Stipend of the Land Steiermark |
| 2004 | Student Travel Stipend. American Society of Mass Spectrometry |
| 2004 | Travel Stipend of the Land Steiermark |
| 2004 | Travel Stipend of the Austrian Chemical Society |
Appointments/Memberships in Professional Societies
| 2019 -2100 | Österreichische Plattform für Personalisierte Medizin Mitglied |
| 2004 -2100 | Gesellschaft Österreichischer Chemiker Mitglied |
Editorial board appointments for scientific journals
| 2019 -2022 | SCIENTIFIC REPORTS: Editorial Board Member |
| 2016 -2020 | MICROBIAL CELL: Editorial Board |
Reviewer for scientific journals
Expert for appointment/habilitation procedures
| 2022 | Berufung: Mitglied: Medizinische Universität Graz Tenure Track Professor of Computational Structural Biology |
| 2022 | Habilitation: Mitglied: Medizinische Universität Graz |
| 2022 | Habilitation: Mitglied: Medizinische Universität Graz |
| 2022 | Berufung: Mitglied: Medizinische Universität Graz Tenure Track Professur für Structural Biology of Proteostasis |
Reviewer/Expert funding organizations
| 2021 -2023 | Österreichische Akademie der Wissenschaften - Austria |
| 2018 -2022 | COFIN Italian Ministery of Science and Research (MUIR Ministerio dell Istruzione, dell Universita e della Ricerca) - Italy |
| 2020 -2022 | Agence Nationale de la Recherche (ANR) - France |
| 2022 -2022 | Slovak Academy of Sciences - Slovakia |
| 2021 -2022 | Dutch Research Council (NWO) - Netherlands |
| 2018 -2022 | European Research Council (ERC) - Belgium |
| 2021 -2022 | Biotechnology and Biological Sciences Research Council - United Kingdom |
| 2020 -2021 | Czech Science Foundation - GA CR - Czech Republic |
| 2019 -2021 | Alexander von Humboldt-Stiftung - Germany |
| 2016 -2021 | Bundesministerium für Wissenschaft und Forschung - Austria |
| 2018 -2021 | Wellcome trust/DBT India Alliance Fellowship - India |
| 2015 -2021 | Israel Science Foundation - Israel |
| 2015 -2021 | Deutsche Forschungsgemeinschaft ( DFG )- Sonderforschungsbereich - Germany |
| 2014 -2021 | Fonds Wetenschappelijk Ondeerzoeck - Vlaanderen - Belgium |
| 2020 -2021 | Wissenschaftlich Technische Zusammenarbeit (WTZ) des BM.WF - Austria |
Organizer of scientific conferences, Chairs
| 2022 | Frontiers in Integrative Structural Biology and Biophysics, Vorsitz Organisator |
| 2020 | ÖGMBT Jahrestagung Wissenschaftlicher Beirat/Beirätin |
| 2019 | Frontiers in Integrative Structural Biology and Biophysics Chair |