Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Wissenschaftszweige, Statistik Austria Klassifikation

Wissenschaftliche Fachkenntnisse


2011 -2013 Sciex postdoctoral fellow, University of Zürich, Switzerland Supervisor: Prof. John A. Robinson Synthesis and characterization of -hairpin shaped cyclic peptidomimetics with antibacterial activities against Gram-negative bacteria. Application of in vivo and in vitro photoaffinity labeling to examine the mode of action of antimicrobial peptidomimetics. Study the binding interaction between antimicrobial peptidomimetics and their identified target proteins using Surface Plasmon Resonance and Isothermal Titration Calorimetry. Expression and isolation of membrane proteins for structural determination by X-ray Crystallography and Nuclear Magnetic Resonance techniques.
2010 Ph.D. in Organic Chemistry, Eötvös Loránd University, Budapest, Hungary. Dissertation: DEVELOPMENT OF MICROWAVE-ASSISTED SYNTHESIS METHODS FOR PREPARATION OF PEPTIDES Supervisors: Prof. Gábor Dibó, Prof. Gábor Mezõ
2009 -2011 Research fellow, Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Budapest, Hungary Supervisor: Prof. Szilvia Bõsze Design and synthesis of peptide conjugates containing new, in silico identified antitubercular drug candidates in order to enhance their cellular uptake. Characterization of the inhibitory effect of compounds in vitro on Mycobacterium tuberculosis strains and their in vitro cytotoxicity and cytostatic effect on different cell lines. Characterization of compounds in vivo toxicology effect and their antitubercular activity in infected guinea pigs.
2006 -2008 Research fellow, Christian Doppler Laboratory for Microwave Chemistry, Institute of Organic and Bioorganic Chemistry, Karl-Franzens University, Graz, Austria Supervisor: Prof. C. Oliver Kappe Development of general synthetic methods for the synthesis of difficult peptide sequences applying controlled microwave heating. Examination the effect of high temperature on amino acid racemization and optimization reaction conditions for the coupling of sensitive amino acid. Study “non-thermal” microwave effect during sold phase peptide synthesis with strictly controlled comparative experiments performed under microwave and conventional heating.
2004 M.Sc. in Chemistry, Eötvös Loránd University, Budapest, Hungary. Dissertation: APPLICATION OF FLUORESCENT LABELING IN COMBINATORIAL CHEMSITRY Supervisor: Prof. Gábor Dibó


2011 Publication award of the Kisfaludy Lajos Foundation Bacsa B, Bősze Sz, Kappe CO. Direct solid-phase synthesis of the -amyloid (1–42) peptide using controlled microwave heating. J. Org. Chem. 2010, 75, 2103–2106.
2006 Poster prize Advances in Microwave-Assisted Organic Synthesis International Conference on Microwave-Assisted Organic Syntheses, Budapest, Hungary Poster entitled: Rapid solid-phase synthesis of a Calmodulin-binding nonapeptide using thermal and controlled microwave irradiation.
2004 Poster Prize: 41th Japanese Peptide Symposium 2004 in conjuction with1st Asian Pacific International, Fukuoka, Japan Poster entitled: Mass spectrometric monitoring of binding assay.
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