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Jahn Stephan |

** = Publications listed in SCI/SSCI/Pubmed

2022

Full paper/article (Journal)

** Klec, C; Knutsen, E; Schwarzenbacher, D; Jonas, K; Pasculli, B; Heitzer, E; Rinner, B; Krajina, K; Prinz, F; Gottschalk, B; Ulz, P; Deutsch, A; Prokesch, A; Jahn, SW; Lellahi, SM; Perander, M; Barbano, R; Graier, WF; Parrella, P; Calin, GA; Pichler, M ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform.
Cell Mol Life Sci. 2022; 79(7): 391 Doi: 10.1007/s00018-022-04402-2 [OPEN ACCESS]
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** Pelzmann, B; Hatab, A; Scheruebel, S; Langthaler, S; Rienmueller, T; Sokolowski, A; Gorischek, A; Platzer, D; Zorn-Pauly, K; Jahn, SW; Bauernhofer, T; Schreibmayer, W Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels
FRONT ONCOL. 2022; 12: 998907 Doi: 10.3389/fonc.2022.998907
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** Singer, CF; Jahn, SW; Rudas, M; Bago-Horvath, Z; Fitzal, F; Abete, L; Moinfar, F; Gnant, M; Filipits, M, , Austrian, Breast, and, Colorectal, Cancer, Study, Group, (ABCSG) Independent validation of stromal uPA in ABCSG-08: Level 1b evidence for the prognostic value of uPA immunohistochemistry.
Breast. 2022; 64:127-133 Doi: 10.1016/j.breast.2022.05.003 [OPEN ACCESS]
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** Suppan, C; Graf, R; Jahn, S; Zhou, Q; Klocker, EV; Bartsch, R; Terbuch, A; Kashofer, K; Regitnig, P; Lindenmann, J; Posch, F; Gerritsmann, H; Jost, PJ; Heitzer, E; Dandachi, N; Balic, M Sensitive and robust liquid biopsy-based detection of PIK3CA mutations in hormone-receptor-positive metastatic breast cancer patients.
Br J Cancer. 2022; 126(3):456-463 Doi: 10.1038/s41416-021-01601-9 [OPEN ACCESS]
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Review

** Jahn, SW; Jost, PJ Challenges in integrating molecular profiles into clinical cancer care
MEMO-MAG EUR MED ONC. 2022; Doi: 10.1007/s12254-022-00838-1
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2021

Full paper/article (Journal)

** Riedl, JM; Hasenleithner, SO; Pregartner, G; Scheipner, L; Posch, F; Groller, K; Kashofer, K; Jahn, SW; Bauernhofer, T; Pichler, M; Stöger, H; Berghold, A; Hoefler, G; Speicher, MR; Heitzer, E; Gerger, A Profiling of circulating tumor DNA and tumor tissue for treatment selection in patients with advanced and refractory carcinoma: a prospective, two-stage phase II Individualized Cancer Treatment trial.
Ther Adv Med Oncol. 2021; 13:1758835920987658 Doi: 10.1177/1758835920987658 [OPEN ACCESS]
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Abstract (Journal)

** Suppan, C; Zhou, Q; Jahn, S; Graf, R; Klocker, EV; Terbuch, A; Kashofer, K; Posch, F; Gerritsmann, H; Dandachi, N; Heitzer, E; Balic, M Comparison of liquid biopsy and tissue based detection of PIK3CAmutations in HR positive metastatic breast cancer patients
CANCER RES. 2021; 81(4): [Poster]
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2020

Full paper/article (Journal)

** Jahn, SW; Bösl, A; Tsybrovskyy, O; Gruber-Rossipal, C; Helfgott, R; Fitzal, F; Knauer, M; Balic, M; Jasarevic, Z; Offner, F; Moinfar, F Clinically high-risk breast cancer displays markedly discordant molecular risk predictions between the MammaPrint and EndoPredict tests.
Br J Cancer. 2020; 122(12):1744-1746 Doi: 10.1038/s41416-020-0838-2 [OPEN ACCESS]
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Review

** Jahn, SW; Plass, M; Moinfar, F Digital Pathology: Advantages, Limitations and Emerging Perspectives.
J Clin Med. 2020; 9(11): Doi: 10.3390/jcm9113697 [OPEN ACCESS]
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Abstract (Journal)

** Gerger, A; Riedl, JM; Perakis, S; Pregartner, G; Scheipner, L; Posch, F; Groller, K; Kashofer, K; Jahn, SW; Bauernhofer, T; Pichler, M; Stoger, H; Berghold, A; Hofler, G; Speicher, M; Heitzer, E Profiling of circulating tumour DNA for treatment selection in patients with advanced and refractory carcinoma: A prospective, two-stage phase II individualized cancer treatment trial.
ANN ONCOL. 2020; 31: S1095-S1096.-ESMO Virtual Congress; SEP 19-OCT 18, 2020; ELECTR NETWORK. Doi: 10.1016/j.annonc.2020.08.1331 [Onlinepräsentation] [OPEN ACCESS]
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** Kirchhoff, E; Petru, E; Tamussino, K; Jahn, SW; Regitnig, P Mucinous Ovarian Cancer: A separate Entity.
GEBURTSH FRAUENHEILK. 2020; 80(4):438-439.-XXVIII. Wissenschaftliche Tagung der Arbeitsgemeinschaft für Gynäkologische Onkologie (AGO) der OEGGG 2020 ; APR 23-25,2020; Salzburg, AUSTRIA. Doi: 10.1055/s-0039-3403410 [Poster]
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** Riedl, J; Perakis, S; Pregartner, G; Scheipner, L; Posch, F; Groller, K; Kashofer, K; Jahn, SW; Bauernhofer, T; Pichler, M; Stoger, H; Berghold, A; Hofler, G; Speicher, M; Heitzer, E; Gerger, A Individualized cancer treatment based on molecular profiling of circulating tumor DNA in patients with advanced and refractory carcinoma: a prospective phase II trial.
ONCOL RES TREAT. 2020; 43(SUPPL 4):249-249.-DGHO Jahrestagung; 09.10. -11.10.2020; Basel (virtueller Kongress). [Oral Communication]
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2019

Full paper/article (Journal)

** Schratter, G; Scheruebel, S; Langthaler, S; Ester, K; Pelzmann, B; Ghaffari-Tabrizi-Wizsy, N; Rezania, S; Gorischek, A; Platzer, D; Zorn-Pauly, K; Ahammer, H; Prokesch, A; Stanzer, S; Devaney, TTJ; Schmidt, K; Jahn, SW; Prassl, R; Bauernhofer, T; Schreibmayer, W; GIRK1 triggers multiple cancer-related pathways in the benign mammary epithelial cell line MCF10A.
SCI REP. 2019; 9: 19277 Doi: 10.1038/s41598-019-55683-w [OPEN ACCESS]
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** Schwarzenbacher, D; Klec, C; Pasculli, B; Cerk, S; Rinner, B; Karbiener, M; Ivan, C; Barbano, R; Ling, H; Wulf-Goldenberg, A; Stanzer, S; Rinnerthaler, G; Stoeger, H; Bauernhofer, T; Haybaeck, J; Hoefler, G; Jahn, SW; Parrella, P; Calin, GA; Pichler, M MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors.
Breast Cancer Res. 2019; 21(1): 20-20. Doi: 10.1186/s13058-019-1104-5 [OPEN ACCESS]
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** Singer, CF; Filipits, M; Jahn, SW; Abete, L; Jakesz, R; Greil, R; Bauernhofer, T; Kwasny, W; Seifert, M; Fitzal, F; Kastner, M; Schmitt, M; Moinfar, F; Gnant, M Stromal coexpression of uPA/PAI-1 protein predicts poor disease outcome in endocrine-treated postmenopausal patients with receptor-positive early breast cancer.
Breast. 2019; 46(14):101-107 Doi: 10.1016/j.breast.2019.05.007 [OPEN ACCESS]
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Abstract (Journal)

** Terzic, J; Fillafer, F; Posch, F; Pichler, R; Seles, M; Niedersuss-Beke, D; Tinchon, C; Loidl, W; Pichler, M; Jahn, S; Stoger, H; Bauernhofer, T; Lymphopenia impairs response to 1st-line tyrosine kinase inhibitor therapy in patients with metastatic clear-cell renal cell carcinoma and modulates the relative efficacy of sunitinib and pazopanib
WIEN KLIN WOCHENSCHR. 2019; 131: S447-S447.-Frühjahrstagung der OeGHO; APR 11-13, 2019; Linz, AUSTRIA. [Poster]
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2018

Abstract (Proceedings)

** Terzic, J; Fillafer, F; Posch, F; Pichler, R; Seles, M; Pichler, M; Jahn, S; Stöger, H; Bauernhofer, T Lymphopenia impairs response to 1st-line therapy with sunitinib and pazopanib in patients with metastatic clear-cell renal cell carcinoma.
Oncology Research and Treatment . 2018; 41(Suppl4):42-43.-Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie,; SEP 28- OCT 2, 2018; Vienna, AUSTRIA. (ISBN: 978-3-318-06425-4 ) [Oral Communication]
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2017

Full paper/article (Journal)

** El-Heliebi, A; Kashofer, K; Fuchs, J; Jahn, SW; Viertler, C; Matak, A; Sedlmayr, P; Hoefler, G Visualization of tumor heterogeneity by in situ padlock probe technology in colorectal cancer.
Histochem Cell Biol. 2017; 148(2):105-115 Doi: 10.1007/s00418-017-1557-5 [OPEN ACCESS]
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2016

Full paper/article (Journal)

** Al-Zoughbi, W; Pichler, M; Gorkiewicz, G; Guertl-Lackner, B; Haybaeck, J; Jahn, SW; Lackner, C; Liegl-Atzwanger, B; Popper, H; Schauer, S; Nusshold, E; Kindt, AS; Trajanoski, Z; Speicher, MR; Haemmerle, G; Zimmermann, R; Zechner, R; Vesely, PW; Hoefler, G Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.
Oncotarget. 2016; 7(23):33832-33840 Doi: 10.18632/oncotarget.9418 [OPEN ACCESS]
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** Jahn, SW; Kashofer, K; Thüringer, A; Abete, L; Winter, E; Eidenhammer, S; Viertler, C; Tavassoli, F; Moinfar, F Mutation Profiling of Usual Ductal Hyperplasia of the Breast Reveals Activating Mutations Predominantly at Different Levels of the PI3K/AKT/mTOR Pathway.
Am J Pathol. 2016; 186(1):15-23 Doi: 10.1016/j.ajpath.2015.09.004 [OPEN ACCESS]
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** Kammerer, S; Jahn, SW; Winter, E; Eidenhammer, S; Rezania, S; Regitnig, P; Pichler, M; Schreibmayer, W; Bauernhofer, T Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry.
J Clin Pathol. 2016; 69(12):1116-1121 Doi: 10.1136/jclinpath-2016-203798 [OPEN ACCESS]
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** Kammerer, S; Sokolowski, A; Hackl, H; Platzer, D; Jahn, SW; El-Heliebi, A; Schwarzenbacher, D; Stiegelbauer, V; Pichler, M; Rezania, S; Fiegl, H; Peintinger, F; Regitnig, P; Hoefler, G; Schreibmayer, W; Bauernhofer, T KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients.
Oncotarget. 2016; 7(51):84705-84717 Doi: 10.18632/oncotarget.13224 [OPEN ACCESS]
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** Rezania, S; Kammerer, S; Li, C; Steinecker-Frohnwieser, B; Gorischek, A; DeVaney, TT; Verheyen, S; Passegger, CA; Tabrizi-Wizsy, NG; Hackl, H; Platzer, D; Zarnani, AH; Malle, E; Jahn, SW; Bauernhofer, T; Schreibmayer, W Overexpression of KCNJ3 gene splice variants affects vital parameters of the malignant breast cancer cell line MCF-7 in an opposing manner.
BMC Cancer. 2016; 16(1):628-628 Doi: 10.1186/s12885-016-2664-8 [OPEN ACCESS]
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** Ulz, P; Thallinger, GG; Auer, M; Graf, R; Kashofer, K; Jahn, SW; Abete, L; Pristauz, G; Petru, E; Geigl, JB; Heitzer, E; Speicher, MR Inferring expressed genes by whole-genome sequencing of plasma DNA.
Nat Genet. 2016; 48(10):1273-1278 Doi: 10.1038/ng.3648
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Review

** Stanta, G; Jahn, SW; Bonin, S; Hoefler, G Tumour heterogeneity: principles and practical consequences.
Virchows Arch. 2016; 469(4):371-384 Doi: 10.1007/s00428-016-1987-9
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Abstract (Journal)

** Kashofer, K; Jahn, S; Halbwedl, I; Hoetler, G Beyond BRCA-HRD scoring using Affymetrix Oncoscan microarrays
VIRCHOWS ARCH. 2016; 469: S203-S203. [Poster]
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** Singer, CF; Filipits, M; Jahn, S; Abete, L; Jakesz, R; Greil, R; Bauernhofer, T; Kwasny, W; Seifert, M; Fitzal, F; Schmitt, M; Moinfar, F; Gnant, M Stromel co-expression of urokinase-type plasminogen activator (uPA) and plasminogen activator Inhibitor (PAI-1) protein by IHC predicts poor disease outcome in endocrine-treated postmenopausal patients with receptor-positive early breast cancer
CANCER RES. 2016; 76: -38th Annual CTRC-AACR San Antonio Breast Cancer Symposium; DEC 08-12, 2015; San Antonio, TX. Doi: 10.1158/1538-7445.SABCS15-P2-08-21 [Poster]
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2015

Full paper/article (Journal)

** Jahn, SW; Kashofer, K; Halbwedl, I; Winter, G; El-Shabrawi-Caelen, L; Mentzel, T; Hoefler, G; Liegl-Atzwanger, B Mutational dichotomy in desmoplastic malignant melanoma corroborated by multigene panel analysis.
Mod Pathol. 2015; 28(7):895-903 Doi: 10.1038/modpathol.2015.39 [OPEN ACCESS]
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** Li, C; Rezania, S; Kammerer, S; Sokolowski, A; Devaney, T; Gorischek, A; Jahn, S; Hackl, H; Groschner, K; Windpassinger, C; Malle, E; Bauernhofer, T; Schreibmayer, W Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line.
Sci Rep. 2015; 5(2):8364-8364 Doi: 10.1038/srep08364 [OPEN ACCESS]
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** Ress, AL; Stiegelbauer, V; Winter, E; Schwarzenbacher, D; Kiesslich, T; Lax, S; Jahn, S; Deutsch, A; Bauernhofer, T; Ling, H; Samonigg, H; Gerger, A; Hoefler, G; Pichler, M MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients.
Mol Carcinog. 2015; 54(11):1442-1450 Doi: 10.1002/mc.22218
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Abstract (Journal)

** Matak, A; Jahn, S; Viertler, C; Thuringer, A; Halbwedl, I; Langner, C; Hoefler, G; Kashofer, K Genetic heterogeneity of colorectal carcinoma in NGS analysis: A complication for molecular diagnosis?
VIRCHOWS ARCH. 2015; 467: S166-S167.-European Congress of Pathology; SEP 5-9, 2015; Belgrade, SERBIA. [Poster]
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** Singer, CF; Filipits, M; Jahn, S; Abete, L; Jakesz, R; Greil, R; Bauernhofer, T; Kwasny, W; Seifert, M; Fitzal, F; Schmitt, M; Moinfar, F; Gnant, M Influence of immunohistological detection of intratumoral urokinase-type plasminogen activator (uPA) on disease outcome in endocrine-treated postmenopausal patients with hormone receptor-positive early breast cancer.
J CLIN ONCOL. 2015; 33(15): Doi: 10.1200/jco.2015.33.15_suppl.551 [Poster]
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2014

Full paper/article (Journal)

** Pichler, M; Ress, AL; Winter, E; Stiegelbauer, V; Karbiener, M; Schwarzenbacher, D; Scheideler, M; Ivan, C; Jahn, SW; Kiesslich, T; Gerger, A; Bauernhofer, T; Calin, GA; Hoefler, G MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients.
Br J Cancer. 2014; 110(6):1614-1621 Doi: 10.1038/bjc.2014.51 [OPEN ACCESS]
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Abstract (Journal)

** Auer, M; Heitzer, E; Ulz, P; Pristauz, G; Petru, E; Jahn, S; Speicher, MR; Geigl, JB; Whole-genome sequencing of plasma DNA reveals frequently occurring copy number changes in patients with metastatic breast cancer.
EUR J CANCER. 2014; 50: S153-S153.-EACR; München. Doi: 10.1016/S0959-8049(14)50562-X [Oral Communication]
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** Kammerer, S; Sokolowski, A; Hackl, H; Jahn, S; Asslaber, M; Symmans, F; Peintinger, F; Regitnig, P; Schreibmayer, W; Bauernhofer, T OVEREXPRESSION OF G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 (GIRK1) IS ASSOCIATED WITH LYMPH NODE METASTASIS AND POOR PROGNOSIS IN BREAST CANCER
ANN ONCOL. . 2014; 25: -IMPAKT Breast Cancer Conference; MAY 08-10, 2014; Brussels, BELGIUM. Doi: 10.1093/annonc/mdu066.21 [Poster]
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2013

Full paper/article (Journal)

** Heitzer, E; Lax, S; Lafer, I; Müller, SM; Pristauz, G; Ulz, P; Jahn, S; Högenauer, C; Petru, E; Speicher, MR; Geigl, JB Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma.
BMC Med Genet. 2013; 14(1):129-129 Doi: 10.1186/1471-2350-14-129 (- Case Report) [OPEN ACCESS]
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** Jahn, S; Zollner, G; Lackner, C; Stauber, RE Severe toxic hepatitis associated with dronedarone.
Curr Drug Saf. 2013; 8(3):201-202 Doi: 10.2174/15748863113089990031 (- Case Report)
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** Zeimet, AG; Reimer, D; Huszar, M; Winterhoff, B; Puistola, U; Azim, SA; Müller-Holzner, E; Ben-Arie, A; van Kempen, LC; Petru, E; Jahn, S; Geels, YP; Massuger, LF; Amant, F; Polterauer, S; Lappi-Blanco, E; Bulten, J; Meuter, A; Tanouye, S; Oppelt, P; Stroh-Weigert, M; Reinthaller, A; Mariani, A; Hackl, W; Netzer, M; Schirmer, U; Vergote, I; Altevogt, P; Marth, C; Fogel, M L1CAM in early-stage type I endometrial cancer: results of a large multicenter evaluation.
J Natl Cancer Inst. 2013; 105(15): 1142-1150. Doi: 10.1093/jnci/djt144 [OPEN ACCESS]
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Abstract (Journal)

** Auer, M; Heitzer, E; Ulz, P; Pristauz, G; Petru, E; Jahn, S; Lafer, I; Pantel, K; Speicher, MR; Geigl, JB Complex tumor genomes inferred from plasma DNA of patients with metastatic breast cancer by whole-genome sequencing
EUR J CANCER. 2013; 49: S399-S399.-17th ECCO / 38th ESMO / 32nd ESTRO European Cancer Congress on Reinforcing Multidisciplinarity; SEP 27-OCT 01, 2013; Amsterdam, NETHERLANDS. [Oral Communication]
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2011

Full paper/article (Journal)

** Gincu, V; Kornprat, P; Thimary, F; Jahn, S; Mischinger, HJ Intestinal obstruction caused by splenosis at the rectosigmoid junction, mimicking malignant pelvic tumor.
Endoscopy. 2011; 43 Suppl 2 UCTN(2):E260-E260 Doi: 10.1055/s-0030-1256523 (- Case Report) [OPEN ACCESS]
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** Jahn, SW; Liegl, B; Leskowschek, H; Spreizer, C; Langner, C Angiosarcoma at the anastomotic site mimicking local recurrence of rectal adenocarcinoma.
Endoscopy. 2011; 43 Suppl 2 UCTN(7):E293-E294 Doi: 10.1055/s-0030-1256450 (- Case Report) [OPEN ACCESS]
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Short report/Letter

** Jahn, SW; Winter, G; Stacher, E; Halbwedl, I; Gattenlöhner, S; Stockinger, R; Spreitzer, S; Waldispuehl-Geigl, J; Geigl, JB; Offner, F; Hoefler, G Multiple intratumoral KRAS mutations can clonally segregate to different lymph node metastases in colon cancer.
Histopathology. 2011; 59(2): 342-345. Doi: 10.1111/j.1365-2559.2011.03902.x (- Case Report)
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2009

Full paper/article (Journal)

** Ausch, C; Buxhofer-Ausch, V; Oberkanins, C; Holzer, B; Minai-Pour, M; Jahn, S; Dandachi, N; Zeillinger, R; Kriegshäuser, G Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization.
J Mol Diagn. 2009; 11(6):508-513 Doi: 10.2353/jmoldx.2009.090022 [OPEN ACCESS]
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Comment

** Jahn, S; Minai-Pour, MB; Speicher, MR; Reiner-Concin, A; Hoefler, G Comprehensive screening for Lynch syndrome: who can be the driving force in daily clinical practice?
J CLIN ONCOL. 2009; 27(13): 2292-2292. Doi: 10.1200/JCO.2009.22.0731 [OPEN ACCESS]
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