Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Dengler Michael |
** = Publikationen gelistet in SCI/SSCI/Pubmed
2023
Originalarbeit (Zeitschrift)
** Moujalled, DM; Brown, FC; Chua, CC; Dengler, MA; Pomilio, G; Anstee, NS; Litalien, V; Thompson, E; Morley, T; MacRaild, S; Tiong, IS; Morris, R; Dun, K; Zordan, A; Shah, J; Banquet, S; Halilovic, E; Morris, E; Herold, MJ; Lessene, G; Adams, JM; Huang, DCS; Roberts, AW; Blombery, P; Wei, AH
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Blood. 2023; 141(6):634-644
Doi: 10.1182/blood.2022016090
PubMed
FullText
FullText_MUG
2022
Originalarbeit (Zeitschrift)
** Blombery, P; Lew, TE; Dengler, MA; Thompson, ER; Lin, VS; Chen, X; Nguyen, T; Panigrahi, A; Handunnetti, SM; Carney, DA; Westerman, DA; Tam, CS; Adams, JM; Wei, AH; Huang, DCS; Seymour, JF; Roberts, AW; Anderson, MA
Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blood. 2022; 139(8):1198-1207
Doi: 10.1182/blood.2021012775
Web of Science
PubMed
FullText
FullText_MUG
** Meinhardt, AL; Munkhbaatar, E; Höckendorf, U; Dietzen, M; Dechant, M; Anton, M; Jacob, A; Steiger, K; Weichert, W; Brcic, L; McGranahan, N; Branca, C; Kaufmann, T; Dengler, MA; Jost, PJ
The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner.
Oncogene. 2022; 41(9):1376-1382
Doi: 10.1038/s41388-021-02161-1
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Übersichtsarbeit
** Balihodzic, A; Prinz, F; Dengler, MA; Calin, GA; Jost, PJ; Pichler, M
Non-coding RNAs and ferroptosis: potential implications for cancer therapy.
Cell Death Differ. 2022; 29(6):1094-1106
Doi: 10.1038/s41418-022-00998-x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Abstract (Zeitschrift)
** Szmyra, MM; Haingartner, S; Jantscher, S; Pansy, K; Uhl, B; Greinix, HT; Neumeister, P; Bernhart, E; Beham-Schmid, C; Dengler, MA; Klosch, B; Deutsch, AJA
The Flavonoid Brusatol Induces Apoptosis in Aggressive Lymphoma Cells and Exhibits Synergistic Effect with Venetoclax
BLOOD. 2022; 140: 4945-4946.
Doi: 10.1182/blood-2022-166678
[Poster]
Web of Science
FullText
FullText_MUG
2021
Originalarbeit (Zeitschrift)
** Dengler, MA; Gibson, L; Adams, JM
BAX mitochondrial integration is regulated allosterically by its α1-α2 loop.
Cell Death Differ. 2021; 28(12):3270-3281
Doi: 10.1038/s41418-021-00815-x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
** Pymm, P; Adair, A; Chan, LJ; Cooney, JP; Mordant, FL; Allison, CC; Lopez, E; Haycroft, ER; O'Neill, MT; Tan, LL; Dietrich, MH; Drew, D; Doerflinger, M; Dengler, MA; Scott, NE; Wheatley, AK; Gherardin, NA; Venugopal, H; Cromer, D; Davenport, MP; Pickering, R; Godfrey, DI; Purcell, DFJ; Kent, SJ; Chung, AW; Subbarao, K; Pellegrini, M; Glukhova, A; Tham, WH
Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
Proc Natl Acad Sci U S A. 2021; 118(19): e2101918118
Doi: 10.1073/pnas.2101918118
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
** Thijssen, R; Diepstraten, ST; Moujalled, D; Chew, E; Flensburg, C; Shi, MX; Dengler, MA; Litalien, V; MacRaild, S; Chen, M; Anstee, NS; Reljić, B; Gabriel, SS; Djajawi, TM; Riffkin, CD; Aubrey, BJ; Chang, C; Tai, L; Xu, Z; Morley, T; Pomilio, G; Bruedigam, C; Kallies, A; Stroud, DA; Bajel, A; Kluck, RM; Lane, SW; Schoumacher, M; Banquet, S; Majewski, IJ; Strasser, A; Roberts, AW; Huang, DCS; Brown, FC; Kelly, GL; Wei, AH
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.
Blood. 2021; 137(20): 2721-2735.
Doi: 10.1182/blood.2020010167
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
2020
Originalarbeit (Zeitschrift)
** Dengler, MA; Teh, CE; Thijssen, R; Gangoda, L; Lan, P; Herold, MJ; Gray, DH; Kelly, GL; Roberts, AW; Adams, JM
Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.
Oncogene. 2020; 39(9):2009-2023
Doi: 10.1038/s41388-019-1122-x
Web of Science
PubMed
FullText
FullText_MUG
** Doerflinger, M; Deng, Y; Whitney, P; Salvamoser, R; Engel, S; Kueh, AJ; Tai, L; Bachem, A; Gressier, E; Geoghegan, ND; Wilcox, S; Rogers, KL; Garnham, AL; Dengler, MA; Bader, SM; Ebert, G; Pearson, JS; De Nardo, D; Wang, N; Yang, C; Pereira, M; Bryant, CE; Strugnell, RA; Vince, JE; Pellegrini, M; Strasser, A; Bedoui, S; Herold, MJ
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.
Immunity. 2020; 53(3):533-547
Doi: 10.1016/j.immuni.2020.07.004
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
** Gangoda, L; Teh, CE; Dengler, MA; Best, SA; Weeden, CE; Tai, L; Lee, EF; Fairlie, WD; Sutherland, KD; Harrison, LC; Gray, DH; Strasser, A; Herold, MJ
Characterization of a novel human BFL-1-specific monoclonal antibody.
Cell Death Differ. 2020; 27(2):826-828
Doi: 10.1038/s41418-019-0454-y
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
** Iyer, S; Uren, RT; Dengler, MA; Shi, MX; Uno, E; Adams, JM; Dewson, G; Kluck, RM
Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.
Cell Death Dis. 2020; 11(4):268-268
Doi: 10.1038/s41419-020-2463-7
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
2019
Originalarbeit (Zeitschrift)
** Dengler, MA; Robin, AY; Gibson, L; Li, MX; Sandow, JJ; Iyer, S; Webb, AI; Westphal, D; Dewson, G; Adams, JM
BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.
Cell Rep. 2019; 27(2):359-373
Doi: 10.1016/j.celrep.2019.03.040
Web of Science
PubMed
FullText
FullText_MUG
2018
Originalarbeit (Zeitschrift)
** Grabow, S; Kueh, AJ; Ke, F; Vanyai, HK; Sheikh, BN; Dengler, MA; Chiang, W; Eccles, S; Smyth, IM; Jones, LK; de Sauvage, FJ; Scott, M; Whitehead, L; Voss, AK; Strasser, A
Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities.
Cell Rep. 2018; 24(12):3285-3295
Doi: 10.1016/j.celrep.2018.08.048
Web of Science
PubMed
FullText
FullText_MUG
2017
Originalarbeit (Zeitschrift)
** Li, MX; Tan, IKL; Ma, SB; Hockings, C; Kratina, T; Dengler, MA; Alsop, AE; Kluck, RM; Dewson, G
BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove.
Proc Natl Acad Sci U S A. 2017; 114(29):7629-7634
Doi: 10.1073/pnas.1702453114
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
** Staiger, AM; Duppel, J; Dengler, MA; van der Kuip, H; Vöhringer, MC; Aulitzky, WE; Rosenwald, A; Ott, G; Horn, H
An analysis of the role of follicular lymphoma-associated fibroblasts to promote tumor cell viability following drug-induced apoptosis.
Leuk Lymphoma. 2017; 58(8):1922-1930
Doi: 10.1080/10428194.2016.1263841
Web of Science
PubMed
FullText
FullText_MUG
2014
Originalarbeit (Zeitschrift)
** Dengler, MA; Weilbacher, A; Gutekunst, M; Staiger, AM; Vöhringer, MC; Horn, H; Ott, G; Aulitzky, WE; van der Kuip, H
Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles' heel in mantle cell lymphoma.
Cell Death Dis. 2014; 5(8):e1013-e1013
Doi: 10.1038/cddis.2013.552
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
2013
Originalarbeit (Zeitschrift)
** Gutekunst, M; Mueller, T; Weilbacher, A; Dengler, MA; Bedke, J; Kruck, S; Oren, M; Aulitzky, WE; van der Kuip, H
Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4.
Cancer Res. 2013; 73(5):1460-1469
Doi: 10.1158/0008-5472.CAN-12-2876
Web of Science
PubMed
FullText
FullText_MUG
** Yilmaz, A; Dengler, MA; van der Kuip, H; Yildiz, H; Rösch, S; Klumpp, S; Klingel, K; Kandolf, R; Helluy, X; Hiller, KH; Jakob, PM; Sechtem, U
Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach.
Eur Heart J. 2013; 34(6):462-475
Doi: 10.1093/eurheartj/ehs366
Web of Science
PubMed
FullText
FullText_MUG
2011
Originalarbeit (Zeitschrift)
** Dengler, MA; Staiger, AM; Gutekunst, M; Hofmann, U; Doszczak, M; Scheurich, P; Schwab, M; Aulitzky, WE; van der Kuip, H
Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis.
PLoS One. 2011; 6(9):e25139-e25139
Doi: 10.1371/journal.pone.0025139
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
** Gutekunst, M; Oren, M; Weilbacher, A; Dengler, MA; Markwardt, C; Thomale, J; Aulitzky, WE; van der Kuip, H
p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin.
PLoS One. 2011; 6(4):e19198-e19198
Doi: 10.1371/journal.pone.0019198
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG