Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Schindl Rainer |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2023

Originalarbeit (Zeitschrift)

** Okutan, B; Schwarze, UY; Berger, L; Martinez, DC; Herber, V; Suljevic, O; Plocinski, T; Swieszkowski, W; Santos, SG; Schindl, R; Löffler, JF; Weinberg, AM; Sommer, NG The combined effect of zinc and calcium on the biodegradation of ultrahigh-purity magnesium implants.
Biomater Adv. 2023; 146:213287 Doi: 10.1016/j.bioadv.2023.213287
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Übersichtsarbeit

** Sallinger, M; Grabmayr, H; Humer, C; Bonhenry, D; Romanin, C; Schindl, R; Derler, I Activation mechanisms and structural dynamics of STIM proteins
J PHYSIOL-LONDON. 2023; Doi: 10.1113/JP283828
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** Ziesel, D; Nowakowska, M; Scheruebel, S; Kornmueller, K; Schäfer, U; Schindl, R; Baumgartner, C; Üçal, M; Rienmüller, T Electrical stimulation methods and protocols for the treatment of traumatic brain injury: a critical review of preclinical research.
J Neuroeng Rehabil. 2023; 20(1): 51 Doi: 10.1186/s12984-023-01159-y [OPEN ACCESS]
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2022

Originalarbeit (Zeitschrift)

** Schmidt, T; Jakesova, M; Derek, V; Kornmueller, K; Tiapko, O; Bischof, H; Burgstaller, S; Waldherr, L; Nowakowska, M; Baumgartner, C; Ucal, M; Leitinger, G; Scheruebel, S; Patz, S; Malli, R; Glowacki, ED; Rienmuller, T; Schindl, R Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision
ADV MATER TECHNOL-US. 2022; 2101159 Doi: 10.1002/admt.202101159
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Abstract (Zeitschrift)

** Waldherr, L; Handl, V; Abrahamsson, T; Sjostrom, TA; Seitanidou, M; Erschen, S; Honeder, S; Tomin, T; Birner-Grunberger, R; Tabrizi-Wizsy, NG; Ropele, S; Ucal, M; Nowakowska, M; Schafer, U; Patz, S; Simon, DT; Schindl, R Insights into the development of tunable brain implants for local chemotherapy
NEURO-ONCOLOGY. 2022; 24: Doi: 10.1093/neuonc/noac174.168 [Poster]
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2021

Originalarbeit (Zeitschrift)

** Bischof, H; Burgstaller, S; Springer, A; Matt, L; Rauter, T; Bachkönig, OA; Schmidt, T; Groschner, K; Schindl, R; Madl, T; Plesnila, N; Lukowski, R; Graier, WF; Malli, R Potassium ions promote hexokinase-II dependent glycolysis.
iScience. 2021; 24(4): 102346-102346. Doi: 10.1016/j.isci.2021.102346 [OPEN ACCESS]
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** Burgstaller, S; Bischof, H; Rauter, T; Schmidt, T; Schindl, R; Patz, S; Groschup, B; Filser, S; van, den, Boom, L; Sasse, P; Lukowski, R; Plesnila, N; Graier, WF; Malli, R Immobilization of Recombinant Fluorescent Biosensors Permits Imaging of Extracellular Ion Signals.
ACS Sens. 2021; 6(11):3994-4000 Doi: 10.1021/acssensors.1c01369 [OPEN ACCESS]
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** Klionsky, DJ; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; Adamopoulos, IE; Adeli, K; Adolph, TE; Adornetto, A; Aflaki, E; Agam, G; Agarwal, A; Aggarwal, BB; Agnello, M; Agostinis, P; Agrewala, JN; Agrotis, A; Aguilar, PV; Ahmad, ST; Ahmed, ZM; Ahumada-Castro, U; Aits, S; Aizawa, S; Akkoc, Y; Akoumianaki, T; Akpinar, HA; Al-Abd, AM; Al-Akra, L; Al-Gharaibeh, A; Alaoui-Jamali, MA; Alberti, S; Alcocer-Gómez, E; Alessandri, C; Ali, M; Alim, Al-Bari, MA; Aliwaini, S; Alizadeh, J; Almacellas, E; Almasan, A; Alonso, A; Alonso, GD; Altan-Bonnet, N; Altieri, DC; Álvarez, ÉMC; Alves, S; Alves, da, Costa, C; Alzaharna, MM; Amadio, M; Amantini, C; Amaral, C; Ambrosio, S; Amer, AO; Ammanathan, V; An, Z; Andersen, SU; Andrabi, SA; Andrade-Silva, M; Andres, AM; Angelini, S; et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
AUTOPHAGY. 2021; 17(1): 1-382. Doi: 10.1080/15548627.2020.1797280 [OPEN ACCESS]
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** Tiffner, A; Hopl, V; Schober, R; Sallinger, M; Grabmayr, H; Hoeglinger, C; Fahrner, M; Lunz, V; Maltan, L; Frischauf, I; Krivic, D; Bhardwaj, R; Schindl, R; Hediger, MA; Derler, I Orai1 Boosts SK3 Channel Activation
CANCERS. 2021; 13(24): 6357 Doi: 10.3390/cancers13246357 [OPEN ACCESS]
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** Tiffner, A; Schober, R; Hoglinger, C; Bonhenry, D; Pandey, S; Lunz, V; Sallinger, M; Frischauf, I; Fahrner, M; Lindinger, S; Maltan, L; Berlansky, S; Stadlbauer, M; Schindl, R; Ettrich, R; Romanin, C; Derler, I CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions
J BIOL CHEM. 2021; 296: 100224 Doi: 10.1074/jbc.RA120.015548 [OPEN ACCESS]
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** Waldherr, L; Seitanidou, M; Jakesova, M; Handl, V; Honeder, S; Nowakowska, M; Tomin, T; Rad, MK; Schmidt, T; Distl, J; Birner-Gruenberger, R; Campe, G; Schafer, U; Berggren, M; Rinner, B; Asslaber, M; Ghaffari-Tabrizi-Wizsy, N; Patz, S; Simon, DT; Schindl, R Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump
ADV MATER TECHNOL-US. 2021; 2001302 Doi: 10.1002/admt.202001302 [OPEN ACCESS]
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Korrektur

** Bischof, H; Burgstaller, S; Springer, A; Matt, L; Rauter, T; Bachkönig, OA; Schmidt, T; Groschner, K; Schindl, R; Madl, T; Plesnila, N; Lukowski, R; Graier, WF; Malli, R Erratum: Potassium ions promote hexokinase-II dependent glycolysis.
iScience. 2021; 24(5): 102468 Doi: 10.1016/j.isci.2021.102468 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Handl, V; Waldherr, L; Patz, S; Schindl, R In vivo tumor treatment with Gemcitabine Ionic Pumps (GemIPs)
EUR BIOPHYS J BIOPHY. 2021; 50(SUPPL 1):98-98.-European Biophysics Conference; JUL, 24-28,2021; Vienna, AUSTRIA. [Poster]
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** Sallinger, M; Bonhenry, D; Grabmayr, H; Humer, C; Berlansky, S; Frischauf, I; Fahrner, M; Romanin, C; Leitner, R; Schindl, R Structure-function analysis and MD-simulations of STIM mediated calcium influx
EUR BIOPHYS J BIOPHY. 2021; 50(SUPPL 1):96-96.-European Biophysics Conference; JUL, 24-28,2021; Vienna, AUSTRIA. [Poster]
Web of Science

 

** Schmidt, T; Rienmuller, T; Kornmuller, K; Glowacki, ED; Schindl, R Light-induced gating of ion channels and action potential stimulation with photosensitive organic semiconductors
EUR BIOPHYS J BIOPHY. 2021; 50(SUPPL 1):65-65.-European Biophysics Conference; JUL, 24-28,2021; Vienna, AUSTRIA. [Oral Communication]
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** Waldherr, L; Seitanidou, M; Jakesova, M; Handl, V; Rad, MK; Patz, S; Simon, DT; Schindl, R An iontronic pump for targeted drug delivery to glioblastoma spheroids
EUR BIOPHYS J BIOPHY. 2021; 50(SUPPL 1):149-149.-European Biophysics Conference; JUL, 24-28,2021; Vienna, AUSTRIA. [Poster]
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Kommentar

** Bonhenry, D; Schober, R; Schindl, R Twisting gating residues in the Orai pore Comment
CELL CALCIUM. 2021; 93: 102323 Doi: 10.1016/j.ceca.2020.102323
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2020

Originalarbeit (Zeitschrift)

** Gibhardt, CS; Cappello, S; Bhardwaj, R; Schober, R; Kirsch, SA; Bonilla Del Rio, Z; Gahbauer, S; Bochicchio, A; Sumanska, M; Ickes, C; Stejerean-Todoran, I; Mitkovski, M; Alansary, D; Zhang, X; Revazian, A; Fahrner, M; Lunz, V; Frischauf, I; Luo, T; Ezerina, D; Messens, J; Belousov, VV; Hoth, M; Böckmann, RA; Hediger, MA; Schindl, R; Bogeski, I Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry.
Cell Rep. 2020; 33(3):108292-108292 Doi: 10.1016/j.celrep.2020.108292 [OPEN ACCESS]
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** Graziani, A; Bacsa, B; Krivic, D; Wiedner, P; Curcic, S; Schindl, R; Tiapko, O; Groschner, K Light-Mediated Control over TRPC3-Mediated NFAT Signaling.
Cells. 2020; 9(3): 556 Doi: 10.3390/cells9030556 [OPEN ACCESS]
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** Pogenberg, V; Ballesteros-Álvarez, J; Schober, R; Sigvaldadóttir, I; Obarska-Kosinska, A; Milewski, M; Schindl, R; Ögmundsdóttir, MH; Steingrímsson, E; Wilmanns, M Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif.
Nucleic Acids Res. 2020; 48(2):934-948 Doi: 10.1093/nar/gkz1104 [OPEN ACCESS]
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** Sallinger, M; Tiffner, A; Schmidt, T; Bonhenry, D; Waldherr, L; Frischauf, I; Lunz, V; Derler, I; Schober, R; Schindl, R Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes.
INT J MOL SCI. 2020; 21(12): 4410 Doi: 10.3390/ijms21124410 [OPEN ACCESS]
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** Waldherr, L; Tiffner, A; Mishra, D; Sallinger, M; Schober, R; Frischauf, I; Schmidt, T; Handl, V; Sagmeister, P; Köckinger, M; Derler, I; Üçal, M; Bonhenry, D; Patz, S; Schindl, R Blockage of Store-Operated Ca2+ Influx by Synta66 is Mediated by Direct Inhibition of the Ca2+ Selective Orai1 Pore.
Cancers (Basel). 2020; 12(10): Doi: 10.3390/cancers12102876 [OPEN ACCESS]
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Originalarbeit (Konferenzband)

** Stoppacher, S; Scheruebel, S; Üçal, M; Kornmüller, K; Głowacki; E; Schindl, R; Shrestha, R; Schmidt, T; Baumgartner, C; Rienmüller, T Modeling External Stimulation of Excitable Cells Using a Novel Light-Activated Organic Semiconductor Technology.
Stud Health Technol Inform. Ebook: dHealth 2020 – Biomedical Informatics for Health and Care. 2020; 271: 9-16.-Studies in Health Technology and Informatics; May, 19; 2020; virtuell (Corona). (ISBN: 978-1-64368-085-9 ) Doi: 10.3233/SHTI200068 [Poster] [OPEN ACCESS]
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2019

Originalarbeit (Zeitschrift)

** Jakešová, M; Silverå Ejneby, M; Đerek, V; Schmidt, T; Gryszel, M; Brask, J; Schindl, R; Simon, DT; Berggren, M; Elinder, F; Głowacki, ED Optoelectronic control of single cells using organic photocapacitors.
SCI ADV. 2019; 5(4): eaav5265-eaav5265. Doi: 10.1126/sciadv.aav5265 [OPEN ACCESS]
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** Schober, R; Bonhenry, D; Lunz, V; Zhu, J; Krizova, A; Frischauf, I; Fahrner, M; Zhang, M; Waldherr, L; Schmidt, T; Derler, I; Stathopulos, PB; Romanin, C; Ettrich, RH; Schindl, R Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.
Sci Signal. 2019; 12(608): Doi: 10.1126/scisignal.aax3194
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Übersichtsarbeit

** Bonhenry, D; Schober, R; Schmidt, T; Waldherr, L; Ettrich, RH; Schindl, R Mechanistic insights into the Orai channel by molecular dynamics simulations.
Semin Cell Dev Biol. 2019; 94(7):50-58 Doi: 10.1016/j.semcdb.2019.01.002
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** Curcic, S; Schober, R; Schindl, R; Groschner, K TRPC-mediated Ca2+ signaling and control of cellular functions.
Semin Cell Dev Biol. 2019; 94:28-39 Doi: 10.1016/j.semcdb.2019.02.001
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** Schober, R; Waldherr, L; Schmidt, T; Graziani, A; Stilianu, C; Legat, L; Groschner, K; Schindl, R STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription.
Biochim Biophys Acta Mol Cell Res. 2019; 1866(7):1079-1091 Doi: 10.1016/j.bbamcr.2018.11.001 [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Fahrner, M; Pandey, SK; Muik, M; Traxler, L; Butorac, C; Stadlbauer, M; Zayats, V; Krizova, A; Plenk, P; Frischauf, I; Schindl, R; Gruber, HJ; Hinterdorfer, P; Ettrich, R; Romanin, C; Derler, I Communication between N terminus and loop2 tunes Orai activation.
J BIOL CHEM. 2018; 293(4): 1271-1285. Doi: 10.1074/jbc.M117.812693 [OPEN ACCESS]
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** Lichtenegger, M; Tiapko, O; Svobodova, B; Stockner, T; Glasnov, TN; Schreibmayer, W; Platzer, D; de la Cruz, GG; Krenn, S; Schober, R; Shrestha, N; Schindl, R; Romanin, C; Groschner, K An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.
Nat Chem Biol. 2018; 14(4):396-404 Doi: 10.1038/s41589-018-0015-6 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Schober, R; Frischauf, I; Lunz, V; Romanin, C; Schindl, R Molecular Insights into the Pathophysiology of the Ca2+ Sensing Protein STIM1
BIOPHYS J. 2018; 114(3):212A-212A.-62nd Annual Meeting of the Biophysical-Society; FEB 17-21, 2018; San Francisco, CA. [Oral Communication]
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** Tiapko, O; Lichtenegger, M; de la Cruz, GG; Glasnov, TN; Svobodova, B; Schreibmayer, W; Platzer, D; Krenn, S; Shrestha, N; Schindl, R; Stockner, T; Romanin, C; Groschner, K Photoswitchable Diacylglycerols Identify a Novel Lipid-Gating Mechanism in TRPC3 Channels
BIOPHYS J. 2018; 114(3):641A-641A.-62nd Annual Meeting of the Biophysical-Society; FEB 17-21, 2018; San Francisco, USA. [Poster]
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2017

Originalarbeit (Zeitschrift)

** Frischauf, I; Litviňuková, M; Schober, R; Zayats, V; Svobodová, B; Bonhenry, D; Lunz, V; Cappello, S; Tociu, L; Reha, D; Stallinger, A; Hochreiter, A; Pammer, T; Butorac, C; Muik, M; Groschner, K; Bogeski, I; Ettrich, RH; Romanin, C; Schindl, R Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Sci Signal. 2017; 10(507): Doi: 10.1126/scisignal.aao0358 [OPEN ACCESS]
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** Sytnyk, M; Jakešová, M; Litviňuková, M; Mashkov, O; Kriegner, D; Stangl, J; Nebesářová, J; Fecher, FW; Schöfberger, W; Sariciftci, NS; Schindl, R; Heiss, W; Głowacki, ED Cellular interfaces with hydrogen-bonded organic semiconductor hierarchical nanocrystals.
Nat Commun. 2017; 8(1):91-91 Doi: 10.1038/s41467-017-00135-0 [OPEN ACCESS]
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Übersichtsarbeit

** Fahrner, M; Schindl, R; Muik, M; Derler, I; Romanin, C The STIM-Orai Pathway: The Interactions Between STIM and Orai.
Adv Exp Med Biol. 2017; 993(14-15):59-81 Doi: 10.1007/978-3-319-57732-6_4
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2016

Originalarbeit (Zeitschrift)

** Derler, I; Jardin, I; Stathopulos, PB; Muik, M; Fahrner, M; Zayats, V; Pandey, SK; Poteser, M; Lackner, B; Absolonova, M; Schindl, R; Groschner, K; Ettrich, R; Ikura, M; Romanin, C Cholesterol modulates Orai1 channel function.
Sci Signal. 2016; 9(412):ra10-ra10 Doi: 10.1126/scisignal.aad7808 [OPEN ACCESS]
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2015

Originalarbeit (Zeitschrift)

** Frischauf, I; Zayats, V; Deix, M; Hochreiter, A; Jardin, I; Muik, M; Lackner, B; Svobodová, B; Pammer, T; Litviňuková, M; Sridhar, AA; Derler, I; Bogeski, I; Romanin, C; Ettrich, RH; Schindl, R A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.
Sci Signal. 2015; 8(408):ra131-ra131 Doi: 10.1126/scisignal.aab1901 [OPEN ACCESS]
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2014

Originalarbeit (Zeitschrift)

** Fahrner, M; Muik, M; Schindl, R; Butorac, C; Stathopulos, P; Zheng, L; Jardin, I; Ikura, M; Romanin, C A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).
J Biol Chem. 2014; 289(48): 33231-33244. Doi: 10.1074/jbc.M114.610022 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Fahrner, M; Muik, M; Schindl, R; Hoeglinger, C; Romanin, C Stim1 Cytosolic Coiled-Coil Interactions in the Resting and Activated State
BIOPHYS J. 2014; 106(2):314A-314A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.1819 [Poster]
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** Frischauf, I; Schindl, R; Zayats, V; Deix, M; Hochreiter, A; Svobodova, B; Ettrich, R; Romanin, C Interplay of Orai1-Loop3 with Extracellular Ca2+ Binding Sites in Loop1 Controls Crac Channel Activity
BIOPHYS J. 2014; 106(2):316A-316A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.1827 [Poster]
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** Schindl, R; Frischauf, I; Zayats, V; Svobodova, B; Deix, M; Muik, M; Hochreiter, A; Ettrich, R; Romanin, C Novel Trans-Membrane Mutation Switches Orai1 to a Constitutively Active and Ca2+ Selective Channel
BIOPHYS J. 2014; 106(2):316A-316A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.1828 [Poster]
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2013

Originalarbeit (Zeitschrift)

** Derler, I; Plenk, P; Fahrner, M; Muik, M; Jardin, I; Schindl, R; Gruber, HJ; Groschner, K; Romanin, C The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
J Biol Chem. 2013; 288(40):29025-29034 Doi: 10.1074/jbc.M113.501510 [OPEN ACCESS]
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** Derler, I; Schindl, R; Fritsch, R; Heftberger, P; Riedl, MC; Begg, M; House, D; Romanin, C The action of selective CRAC channel blockers is affected by the Orai pore geometry.
Cell Calcium. 2013; 53(2): 139-151. Doi: 10.1016/j.ceca.2012.11.005 [OPEN ACCESS]
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** González-Cobos, JC; Zhang, X; Zhang, W; Ruhle, B; Motiani, RK; Schindl, R; Muik, M; Spinelli, AM; Bisaillon, JM; Shinde, AV; Fahrner, M; Singer, HA; Matrougui, K; Barroso, M; Romanin, C; Trebak, M Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia.
Circ Res. 2013; 112(7): 1013-1025. Doi: 10.1161/CIRCRESAHA.111.300220 [OPEN ACCESS]
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** Stathopulos, PB; Schindl, R; Fahrner, M; Zheng, L; Gasmi-Seabrook, GM; Muik, M; Romanin, C; Ikura, M STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.
Nat Commun. 2013; 4(48): 2963-2963. Doi: 10.1038/ncomms3963 [OPEN ACCESS]
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** Zhang, X; González-Cobos, JC; Schindl, R; Muik, M; Ruhle, B; Motiani, RK; Bisaillon, JM; Zhang, W; Fahrner, M; Barroso, M; Matrougui, K; Romanin, C; Trebak, M Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.
Mol Cell Biol. 2013; 33(18): 3715-3723. Doi: 10.1128/MCB.00554-13 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Schindl, R; Fahrner, M; Muik, M; Hoglinger, C; Romanin, C Activation mechanism of the store-operated calcium channel complex STIM1 and Orai1
EUR BIOPHYS J BIOPHY. 2013; 42: S76-S76.-9th European-Biophysical-Societies-Association Congress; JUL 13-17, 2013; Lisbon, PORTUGAL. [Oral Communication]
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** Schindl, R; Fritsch, R; Jardin, I; Frischauf, I; Kahr, H; Muik, M; Riedl, MC; Groschner, K; Romanin, C; TRPC 1 acts as a Negative Regulator for TRPV6 Mediated Ca2+ Influx.
BIOPHYS J. 2013; 104(2):457A-457A.-57th Annual Meeting of the Biophysical-Society; FEB 02-06, 2013; Philadelphia, PA. Doi: 10.1016/j.bpj.2012.11.2529 [Poster]
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2012

Originalarbeit (Zeitschrift)

** Schindl, R; Fritsch, R; Jardin, I; Frischauf, I; Kahr, H; Muik, M; Riedl, MC; Groschner, K; Romanin, C Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.
J Biol Chem. 2012; 287(42):35612-35620 Doi: 10.1074/jbc.M112.400952 [OPEN ACCESS]
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Übersichtsarbeit

** Derler, I; Schindl, R; Fritsch, R; Romanin, C Gating and permeation of Orai channels.
Front Biosci (Landmark Ed). 2012; 17(24): 1304-1322. Doi: 10.2741/3988
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** Muik, M; Schindl, R; Fahrner, M; Romanin, C Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.
Cell Mol Life Sci. 2012; 69(24): 4163-4176. Doi: 10.1007/s00018-012-1072-8 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Derler, I; Schindl, R; Heftberger, P; Fritsch, R; Begg, M; House, D; Romanin, C Two Novel CRAC Channel Inhibitors Targeting the Orai Pore
BIOPHYS J. 2012; 102(3):314A-315A.-56th Annual Meeting of the Biophysical-Society; FEB 25-29, 2012; San Diego, CA. Doi: 10.1016/j.bpj.2011.11.1731 [Poster]
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** Fahrner, M; Muik, M; Lohninger, B; Schindl, R; Romanin, C Conformational Rearrangements of STIM1 Cytosolic Portion Sensed by Altered Coiled-Coil Accessibility
BIOPHYS J. 2012; 102(3):313A-314A.-56th Annual Meeting of the Biophysical-Society; FEB 25-29, 2012; San Diego, CA. Doi: 10.1016/j.bpj.2011.11.1726 [Poster]
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** Frischauf, I; Schindl, R; Lackner, B; Romanin, C Flexibility of the Third Extracellular Loop Affects Permeation of Orai1 Channels
BIOPHYS J. 2012; 102(3):314A-314A.-56th Annual Meeting of the Biophysical-Society; FEB 25-29, 2012; San Diego, CA. Doi: 10.1016/j.bpj.2011.11.1729 [Poster]
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2011

Originalarbeit (Zeitschrift)

** Frischauf, I; Schindl, R; Bergsmann, J; Derler, I; Fahrner, M; Muik, M; Fritsch, R; Lackner, B; Groschner, K; Romanin, C Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.
J Biol Chem. 2011; 286(10):8577-8584 Doi: 10.1074/jbc.M110.187179 [OPEN ACCESS]
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** Muik, M; Fahrner, M; Schindl, R; Stathopulos, P; Frischauf, I; Derler, I; Plenk, P; Lackner, B; Groschner, K; Ikura, M; Romanin, C STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation.
EMBO J. 2011; 30(9): 1678-1689. Doi: 10.1038/emboj.2011.79 [OPEN ACCESS]
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** Zheng, L; Stathopulos, PB; Schindl, R; Li, GY; Romanin, C; Ikura, M Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry.
Proc Natl Acad Sci U S A. 2011; 108(4): 1337-1342. Doi: 10.1073/pnas.1015125108 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Lackner, B; Derler, I; Fahrner, M; Bergsmann, J; Frischauf, I; Muik, M; Schindl, R; Groschner, K; Romanin, C Orai Coordinates Multiple Regulatory Processes via its N-Terminal Conserved Domain
BIOPHYS J. 2011; 100(3): 83-84.
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** Muik, M; Fahrner, M; Schindl, R; Frischauf, I; Derler, I; Barbara, L; Plenk, P; Groschner, K; Romanin, C STIM1 Rearranges into an Extended Conformation upon Interaction with Orai1
BIOPHYS J. 2011; 100(3): 83-83.
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** Schindl, R; Frischauf, I; Bergsmann, J; Derler, I; Fahrner, M; Fritsch, R; Lackner, B; Groschner, K; Romanin, C Cooperativeness of Orai Cytosolic Domains Tunes Subtype-Specific Gating
BIOPHYS J. 2011; 100(3): 181-182.
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2010

Originalarbeit (Zeitschrift)

** Sponder, G; Svidova, S; Schindl, R; Wieser, S; Schweyen, RJ; Romanin, C; Froschauer, EM; Weghuber, J Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.
FEBS J. 2010; 277(17): 3514-3525. Doi: 10.1111/j.1742-4658.2010.07761.x [OPEN ACCESS]
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Abstract (Zeitschrift)

** Muik, M; Fahrner, M; Schindl, R; Derler, I; Frischauf, I; Bergsmann, J; Fritsch, R; Groschner, K; Romanin, C Conformational Rearrangement within STIM1 C-terminus Crucial for Coupling to Orai1
BIOPHYS J. 2010; 98(3): 676A-677A. Doi: 10.1016/j.bpj.2009.12.3717
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** Schindl, R; Frischauf, I; Bergsmann, J; Romanin, C The Second Loop of Orai Channels Fine-Tunes Ca2+ Feedback Regulation
BIOPHYS J. 2010; 98(3): 676A-676A. Doi: 10.1016/j.bpj.2009.12.3714
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2009

Originalarbeit (Zeitschrift)

** Derler, I; Fahrner, M; Carugo, O; Muik, M; Bergsmann, J; Schindl, R; Frischauf, I; Eshaghi, S; Romanin, C Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant.
J Biol Chem. 2009; 284(23): 15903-15915. Doi: 10.1074/jbc.M808312200 [OPEN ACCESS]
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** Derler, I; Fahrner, M; Muik, M; Lackner, B; Schindl, R; Groschner, K; Romanin, C A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.
J Biol Chem. 2009; 284(37): 24933-24938. Doi: 10.1074/jbc.C109.024083 [OPEN ACCESS]
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** Frischauf, I; Muik, M; Derler, I; Bergsmann, J; Fahrner, M; Schindl, R; Groschner, K; Romanin, C Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
J Biol Chem. 2009; 284(32): 21696-21706. Doi: 10.1074/jbc.M109.018408 [OPEN ACCESS]
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** Muik, M; Fahrner, M; Derler, I; Schindl, R; Bergsmann, J; Frischauf, I; Groschner, K; Romanin, C A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
J Biol Chem. 2009; 284(13):8421-8426 Doi: 10.1074/jbc.C800229200 [OPEN ACCESS]
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** Schindl, R; Frischauf, I; Bergsmann, J; Muik, M; Derler, I; Lackner, B; Groschner, K; Romanin, C Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.
Proc Natl Acad Sci U S A. 2009; 106(46): 19623-19628. Doi: 10.1073/pnas.0907714106 [OPEN ACCESS]
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Übersichtsarbeit

** Fahrner, M; Muik, M; Derler, I; Schindl, R; Fritsch, R; Frischauf, I; Romanin, C Mechanistic view on domains mediating STIM1-Orai coupling.
Immunol Rev. 2009; 231(1): 99-112. Doi: 10.1111/j.1600-065X.2009.00815.x
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** Schindl, R; Muik, M; Fahrner, M; Derler, I; Fritsch, R; Bergsmann, J; Romanin, C Recent progress on STIM1 domains controlling Orai activation.
Cell Calcium. 2009; 46(4): 227-232. Doi: 10.1016/j.ceca.2009.08.003
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2008

Originalarbeit (Zeitschrift)

** Derler, I; Fritsch, R; Schindl, R; Romanin, C CRAC inhibitors: identification and potential.
Expert Opin Drug Discov. 2008; 3(7): 787-800. Doi: 10.1517/17460441.3.7.787
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** Muik, M; Frischauf, I; Derler, I; Fahrner, M; Bergsmann, J; Eder, P; Schindl, R; Hesch, C; Polzinger, B; Fritsch, R; Kahr, H; Madl, J; Gruber, H; Groschner, K; Romanin, C Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.
J Biol Chem. 2008; 283(12):8014-8022 Doi: 10.1074/jbc.M708898200 [OPEN ACCESS]
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** Schindl, R; Bergsmann, J; Frischauf, I; Derler, I; Fahrner, M; Muik, M; Fritsch, R; Groschner, K; Romanin, C 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.
J Biol Chem. 2008; 283(29):20261-20267 Doi: 10.1074/jbc.M803101200 [OPEN ACCESS]
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** Schindl, R; Frischauf, I; Kahr, H; Fritsch, R; Krenn, M; Derndl, A; Vales, E; Muik, M; Derler, I; Groschner, K; Romanin, C The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.
Cell Calcium. 2008; 43(3): 260-269. Doi: 10.1016/j.ceca.2007.05.015
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Übersichtsarbeit

** Frischauf, I; Schindl, R; Derler, I; Bergsmann, J; Fahrner, M; Romanin, C The STIM/Orai coupling machinery.
Channels (Austin). 2008; 2(4): 261-268. Doi: 10.4161/chan.2.4.6705 [OPEN ACCESS]
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2007

Originalarbeit (Zeitschrift)

** Schindl, R; Weghuber, J; Romanin, C; Schweyen, RJ Mrs2p forms a high conductance Mg2+ selective channel in mitochondria.
Biophys J. 2007; 93(11): 3872-3883. Doi: 10.1529/biophysj.107.112318 [OPEN ACCESS]
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Übersichtsarbeit

** Schindl, R; Romanin, C Assembly domains in TRP channels.
Biochem Soc Trans. 2007; 35(Pt 1): 84-85. Doi: 10.1042/BST0350084
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Abstract (Zeitschrift)

** Derler, I; Schindl, R; Kabr, H; Muik, M; Fritsch, R; Lehen'kyi, V; Prevarskaya, N; Hediger, M; Groschner, K; Romanin, C Molecular components contributing to store-operated current (SOC) in prostate cancer cell line LNCaP
BIOPHYS J. 2007; 590A-590A.
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** Schindl, R; Weghuber, J; Schweyen, RJ; Romanin, C Mrs2 forms a high conductance Mg2+ permeable channel in mitochondria
BIOPHYS J. 2007; 437A-438A.
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2006

Originalarbeit (Zeitschrift)

** Derler, I; Hofbauer, M; Kahr, H; Fritsch, R; Muik, M; Kepplinger, K; Hack, ME; Moritz, S; Schindl, R; Groschner, K; Romanin, C Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.
J Physiol. 2006; 577(Pt 1): 31-44. Doi: 10.1113/jphysiol.2006.118661 [OPEN ACCESS]
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2005

Abstract (Zeitschrift)

** Hofbauer, M; Fritsch, R; Kahr, H; Schindl, R; Groschner, K; Romanin, C In vivo interaction of calmodulin (CaM) with TRFV6 channels evaluated by confocal FRET microscopy
BIOPHYS J. 2005; 88(1): 113A-113A.
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** Schindl, R; Frischauf, I; Kahr, H; Vales, E; Groschner, K; Romanin, C Homo- and heteromultimerization of TRPC4 and TRPC5 is dependent on ankyrin-like repeats
BIOPHYS J. 2005; 88(1): 113A-114A.
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** Schindl, R; Kahr, H; Hack, ME; Fritsch, R; Hediger, M; Groschner, K; Romanin, C TRPV6 is a component of the store-operated channel in LNCaP prostate carcionoma cells
BIOPHYS J. 2005; 88(1): 114A-115A.
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2004

Originalarbeit (Zeitschrift)

** Kahr, H; Schindl, R; Fritsch, R; Heinze, B; Hofbauer, M; Hack, ME; Mörtelmaier, MA; Groschner, K; Peng, JB; Takanaga, H; Hediger, MA; Romanin, C CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells.
J Physiol. 2004; 557(Pt 1):121-132 Doi: 10.1113/jphysiol.2004.062653 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Kahr, H; Schindl, R; Hack, ME; Groschner, K; Romanin, C Dominant negative function of TRPV6 n-terminal fragments
BIOPHYS J. 2004; 86(1): 453A-453A.
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** Schindl, R; Kahr, H; Fritsch, R; Heinze, B; Hofbauer, M; Hack, ME; Groschner, K; Peng, JB; Takanaga, H; Hediger, MA; Romanin, C CaT1 is not a component of CRAC in mucosal-type mast cells
N-S ARCH PHARMACOL. 2004; 369: R59-R59.
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** Schindl, R; Kahr, H; Hack, ME; Heinze, B; Groschner, K; Romanin, C A N-terminal fragment of CaT1 inhibits CRAC in mast cells
BIOPHYS J. 2004; 86(1): 457A-457A.
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2003

Originalarbeit (Zeitschrift)

** Poteser, M; Wakabayashi, I; Rosker, C; Teubl, M; Schindl, R; Soldatov, NM; Romanin, C; Groschner, K Crosstalk between voltage-independent Ca2+ channels and L-type Ca2+ channels in A7r5 vascular smooth muscle cells at elevated intracellular pH: evidence for functional coupling between L-type Ca2+ channels and a 2-APB-sensitive cation channel.
Circ Res. 2003; 92(8):888-896 Doi: 10.1161/01.RES.0000069216.80612.66 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Kahr, H; Schindl, R; Fritsch, R; Groschner, K; Romanin, C Is the CaT1 protein a subunit of CRAC in RBL mast cells?
BIOPHYS J. 2003; 84(2): 59A-60A.
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** Schindl, R; Graz, IM; Kahr, H; Groschner, K; Romanin, C A calcium channel in LNCaP cells sensitive to intracellular ca2+and Mg-ATP
BIOPHYS J. 2003; 84(2): 389A-389A.
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2002

Originalarbeit (Zeitschrift)

** Schindl, R; Kahr, H; Graz, I; Groschner, K; Romanin, C Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels.
J Biol Chem. 2002; 277(30):26950-26958 Doi: 10.1074/jbc.M203700200 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Kahr, H; Schindl, R; Groschner, K; Soldatov, NM; Romanin, C Effects of N- and C-terminal lobe of calmodulin on Ca2+-dependent inactivation of Cav1.2 channel
BIOPHYS J. 2002; 82(1): 106A-106A.
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** Schindl, R; Romanin, C A 2-APB-sensitive component converts a constitutively active CaT1-derived Ca2+ conductance into a store depletion activated conductance
BIOPHYS J. 2002; 82(1): 21A-22A.
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