** = Publikationen gelistet in SCI/SSCI/Pubmed
** Barth, DA; Stanzer, S; Spiegelberg, J; Bauernhofer, T; Absenger, G; Posch, F; Lipp, R; Halm, M; Szkandera, J; Balic, M; Gerger, A; Smolle, MA; Hutterer, GC; Klec, C; Jost, PJ; Kargl, J; Stradner, M; Pichler, M
Evaluation of autoantibodies as predictors of treatment response and immune-related adverse events during the treatment with immune checkpoint inhibitors: A prospective longitudinal pan-cancer study.
Cancer Med. 2022; 11(16):3074-3083
Doi: 10.1002/cam4.4675
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** Barth, DA; Stanzer, S; Spiegelberg, JA; Bauernhofer, T; Absenger, G; Szkandera, J; Gerger, A; Smolle, MA; Hutterer, GC; Ahyai, SA; Madl, T; Posch, F; Riedl, JM; Klec, C; Jost, PJ; Kargl, J; Stradner, MH; Pichler, M
Patterns of Peripheral Blood B-Cell Subtypes Are Associated With Treatment Response in Patients Treated With Immune Checkpoint Inhibitors: A Prospective Longitudinal Pan-Cancer Study.
Front Immunol. 2022; 13: 840207
Doi: 10.3389/fimmu.2022.840207
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** Klec, C; Knutsen, E; Schwarzenbacher, D; Jonas, K; Pasculli, B; Heitzer, E; Rinner, B; Krajina, K; Prinz, F; Gottschalk, B; Ulz, P; Deutsch, A; Prokesch, A; Jahn, SW; Lellahi, SM; Perander, M; Barbano, R; Graier, WF; Parrella, P; Calin, GA; Pichler, M
ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform.
Cell Mol Life Sci. 2022; 79(7): 391
Doi: 10.1007/s00018-022-04402-2
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** Prinz, F; Jonas, K; Balihodzic, A; Klec, C; Reicher, A; Barth, DA; Riedl, J; Gerger, A; Kiesslich, T; Mayr, C; Rinner, B; Kargl, J; Pichler, M
MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response.
RNA Biol. 2022; 19(1):1305-1315
Doi: 10.1080/15476286.2022.2152978
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** Posch, F; Prinz, F; Balihodzic, A; Mayr, C; Kiesslich, T; Klec, C; Jonas, K; Barth, DA; Riedl, JM; Gerger, A; Pichler, M
MiR-200c-3p Modulates Cisplatin Resistance in Biliary Tract Cancer by ZEB1-Independent Mechanisms.
Cancers (Basel). 2021; 13(16):
Doi: 10.3390/cancers13163996
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** Laprovitera, N; Riefolo, M; Ambrosini, E; Klec, C; Pichler, M; Ferracin, M
Cancer of Unknown Primary: Challenges and Progress in Clinical Management.
Cancers (Basel). 2021; 13(3):
Doi: 10.3390/cancers13030451
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** Pichler, M; Rodriguez-Aguayo, C; Nam, SY; Dragomir, MP; Bayraktar, R; Anfossi, S; Knutsen, E; Ivan, C; Fuentes-Mattei, E; Lee, SK; Ling, H; Catela Ivkovic, T; Huang, G; Huang, L; Okugawa, Y; Katayama, H; Taguchi, A; Bayraktar, E; Bhattacharya, R; Amero, P; He, WR; Tran, AM; Vychytilova-Faltejskova, P; Klec, C; Bonilla, DL; Zhang, X; Kapitanovic, S; Loncar, B; Gafà, R; Wang, Z; Cristini, V; Hanash, SM; Bar-Eli, M; Lanza, G; Slaby, O; Goel, A; Rigoutsos, I; Lopez-Berestein, G; Calin, GA
Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.
Gut. 2020; 69(10): 1818-1831.
Doi: 10.1136/gutjnl-2019-318903
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** Seles, M; Hutterer, GC; Foßelteder, J; Svoboda, M; Resel, M; Barth, DA; Pichler, R; Bauernhofer, T; Zigeuner, RE; Pummer, K; Slaby, O; Klec, C; Pichler, M
Long Non-Coding RNA PANTR1 is Associated with Poor Prognosis and Influences Angiogenesis and Apoptosis in Clear-Cell Renal Cell Cancer.
Cancers (Basel). 2020; 12(5): 1200
Doi: 10.3390/cancers12051200
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** Barth, DA; Prinz, F; Teppan, J; Jonas, K; Klec, C; Pichler, M
Long-Noncoding RNA (lncRNA) in the Regulation of Hypoxia-Inducible Factor (HIF) in Cancer.
Noncoding RNA. 2020; 6(3):
Doi: 10.3390/ncrna6030027
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** Henzinger, H; Barth, DA; Klec, C; Pichler, M
Non-Coding RNAs and SARS-Related Coronaviruses.
Viruses. 2020; 12(12):
Doi: 10.3390/v12121374
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** Teppan, J; Barth, DA; Prinz, F; Jonas, K; Pichler, M; Klec, C
Involvement of Long Non-Coding RNAs (lncRNAs) in Tumor Angiogenesis.
Noncoding RNA. 2020; 6(4):
Doi: 10.3390/ncrna6040042
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** Klec, C; Kapeller, A; Prinz, F; Trenk, C; Stoger, H; Pichler, M
Dissecting the interplay of the long non-coding RNA NORAD and PARP inhibitors in triple negative breast cancer.
CANCER RES. 2020; 80(4):-San Antonio Breast Cancer Symposium; DEC 10-14, 2019; San Antonio, TX.
Doi: 10.1158/1538-7445.SABCS19-P1-05-13
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** Klec, C; Schwarzenbacher, D; Gottschalk, B; Margit, R; Prinz, F; Bauernhofer, T; Stoeger, H; Graier, WF; Pichler, M
Deciphering the interplay between nuclear RNA export factors and long non-coding RNAs in breast cancer metabolism.
ANN ONCOL. ESMO Breast Cancer Virtual Meeting 2020. 2020; 31(S2):S38-S38.-ESMO Breast Cancer Virtual Meeting; MAY 23-24, 2020; ELECTR NETWORK.
Doi: 10.1016/j.annonc.2020.03.202
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** Gottschalk, B; Klec, C; Leitinger, G; Bernhart, E; Rost, R; Bischof, H; Madreiter-Sokolowski, CT; Radulović, S; Eroglu, E; Sattler, W; Waldeck-Weiermair, M; Malli, R; Graier, WF
MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex.
Nat Commun. 2019; 10(1):3732-3732
Doi: 10.1038/s41467-019-11692-x
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** Klec, C; Gutschner, T; Panzitt, K; Pichler, M
Involvement of long non-coding RNA HULC (highly up-regulated in liver cancer) in pathogenesis and implications for therapeutic intervention.
Expert Opin Ther Targets. 2019; 23(3): 177-186.
Doi: 10.1080/14728222.2019.1570499
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** Klec, C; Madreiter-Sokolowski, CT; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF
Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.
Cell Physiol Biochem. 2019; 52(1): 57-75.
Doi: 10.33594/000000005
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** Klec, C; Madreiter-Sokolowski, CT; Ziomek, G; Stryeck, S; Sachdev, V; Duta-Mare, M; Gottschalk, B; Depaoli, MR; Rost, R; Hay, J; Waldeck-Weiermair, M; Kratky, D; Madl, T; Malli, R; Graier, WF
Presenilin-1 Established ER-Ca2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose.
Cell Physiol Biochem. 2019; 53(3): 573-586.
Doi: 10.33594/000000158
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** Madreiter-Sokolowski, CT; Waldeck-Weiermair, M; Bourguignon, MP; Villeneuve, N; Gottschalk, B; Klec, C; Stryeck, S; Radulovic, S; Parichatikanond, W; Frank, S; Madl, T; Malli, R; Graier, WF
Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging.
Redox Biol. 2019; 20:458-466
Doi: 10.1016/j.redox.2018.11.003
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** Schwarzenbacher, D; Klec, C; Pasculli, B; Cerk, S; Rinner, B; Karbiener, M; Ivan, C; Barbano, R; Ling, H; Wulf-Goldenberg, A; Stanzer, S; Rinnerthaler, G; Stoeger, H; Bauernhofer, T; Haybaeck, J; Hoefler, G; Jahn, SW; Parrella, P; Calin, GA; Pichler, M
MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors.
Breast Cancer Res. 2019; 21(1): 20-20.
Doi: 10.1186/s13058-019-1104-5
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** Tiapko, O; Shrestha, N; Lindinger, S; Guedes de la Cruz, G; Graziani, A; Klec, C; Butorac, C; Graier, WF; Kubista, H; Freichel, M; Birnbaumer, L; Romanin, C; Glasnov, T; Groschner, K
Lipid-independent control of endothelial and neuronal TRPC3 channels by light.
Chem Sci. 2019; 10(9):2837-2842
Doi: 10.1039/c8sc05536j
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** Waldeck-Weiermair, M; Gottschalk, B; Madreiter-Sokolowski, CT; Ramadani-Muja, J; Ziomek, G; Klec, C; Burgstaller, S; Bischof, H; Depaoli, MR; Eroglu, E; Malli, R; Graier, WF
Development and Application of Sub-Mitochondrial Targeted Ca2 + Biosensors.
Front Cell Neurosci. 2019; 13: 449-449.
Doi: 10.3389/fncel.2019.00449
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** Barth, DA; Slaby, O; Klec, C; Juracek, J; Drula, R; Calin, GA; Pichler, M
Current Concepts of Non-Coding RNAs in the Pathogenesis of Non-Clear Cell Renal Cell Carcinoma.
Cancers (Basel). 2019; 11(10):
Doi: 10.3390/cancers11101580
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** Klec, C; Prinz, F; Pichler, M
Involvement of the long noncoding RNA NEAT1 in carcinogenesis.
Mol Oncol. 2019; 13(1):46-60
Doi: 10.1002/1878-0261.12404
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** Klec, C; Ziomek, G; Pichler, M; Malli, R; Graier, WF
Calcium Signaling in ß-cell Physiology and Pathology: A Revisit.
Int J Mol Sci. 2019; 20(24):
Doi: 10.3390/ijms20246110
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** Prinz, F; Kapeller, A; Pichler, M; Klec, C
The Implications of the Long Non-Coding RNA NEAT1 in Non-Cancerous Diseases.
Int J Mol Sci. 2019; 20(3):
Doi: 10.3390/ijms20030627
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** Depaoli, MR; Karsten, F; Madreiter-Sokolowski, CT; Klec, C; Gottschalk, B; Bischof, H; Eroglu, E; Waldeck-Weiermair, M; Simmen, T; Graier, WF; Malli, R
Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells.
Cell Rep. 2018; 25(2):501-512
Doi: 10.1016/j.celrep.2018.09.027
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** Gottschalk, B; Klec, C; Waldeck-Weiermair, M; Malli, R; Graier, WF
Intracellular Ca2+ release decelerates mitochondrial cristae dynamics within the junctions to the endoplasmic reticulum.
Pflugers Arch. 2018; 470(8):1193-1203
Doi: 10.1007/s00424-018-2133-0
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** Terbuch, A; Adiprasito, JB; Stiegelbauer, V; Seles, M; Klec, C; Pichler, GP; Resel, M; Posch, F; Lembeck, AL; Stöger, H; Szkandera, J; Pummer, K; Bauernhofer, T; Hutterer, GC; Gerger, A; Stotz, M; Pichler, M
MiR-371a-3p Serum Levels Are Increased in Recurrence of Testicular Germ Cell Tumor Patients.
Int J Mol Sci. 2018; 19(10):
Doi: 10.3390/ijms19103130
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** Eroglu, E; Rost, R; Bischof, H; Blass, S; Schreilechner, A; Gottschalk, B; Depaoli, MR; Klec, C; Charoensin, S; Madreiter-Sokolowski, CT; Ramadani, J; Waldeck-Weiermair, M; Graier, WF; Malli, R
Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells.
J Vis Exp. 2017; 5(121):
Doi: 10.3791/55486
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** Madreiter-Sokolowski, CT; Győrffy, B; Klec, C; Sokolowski, AA; Rost, R; Waldeck-Weiermair, M; Malli, R; Graier, WF
UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients.
Oncotarget. 2017; 8(46):80278-80285
Doi: 10.18632/oncotarget.20571
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** Madreiter-Sokolowski, CT; Gottschalk, B; Parichatikanond, W; Eroglu, E; Klec, C; Waldeck-Weiermair, M; Malli, R; Graier, WF
Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria.
Cell Physiol Biochem. 2016; 39(4):1404-1420
Doi: 10.1159/000447844
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** Madreiter-Sokolowski, CT; Klec, C; Parichatikanond, W; Stryeck, S; Gottschalk, B; Pulido, S; Rost, R; Eroglu, E; Hofmann, NA; Bondarenko, AI; Madl, T; Waldeck-Weiermair, M; Malli, R; Graier, WF
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.
Nat Commun. 2016; 7(4):12897-12897
Doi: 10.1038/ncomms12897
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** Waldeck-Weiermair, M; Bischof, H; Blass, S; Deak, AT; Klec, C; Graier, T; Roller, C; Rost, R; Eroglu, E; Gottschalk, B; Hofmann, NA; Graier, WF; Malli, R
Generation of Red-Shifted Cameleons for Imaging Ca²⁺ Dynamics of the Endoplasmic Reticulum.
Sensors (Basel). 2015; 15(6):13052-13068
Doi: 10.3390/s150613052
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** Waldeck-Weiermair, M; Malli, R; Parichatikanond, W; Gottschalk, B; Madreiter-Sokolowski, CT; Klec, C; Rost, R; Graier, WF
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.).
Sci Rep. 2015; 5(50):15602-15602
Doi: 10.1038/srep15602
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** Hofmann, NA; Barth, S; Waldeck-Weiermair, M; Klec, C; Strunk, D; Malli, R; Graier, WF
TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation.
Biol Open. 2014; 3(12):1164-1172
Doi: 10.1242/bio.20149571
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