Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Universitätsklinik für Innere Medizin

Klinische Abteilung für Kardiologie

SCI/PUBMED gelistet | alle Publikationstypen | Gesamt nach Jahr und Erstautor | MUG-Autor*innen |

** = Publikationen gelistet in SCI/SSCI/Pubmed

Originalarbeit (Zeitschrift)

** Amrein, K; Dobnig, H; Wagner, D; Piswanger-Sölkner, C; Pieber, TR; Pilz, S; Tomaschitz, A; Dimai, HP; Fahrleitner-Pammer, A Sclerostin in institutionalized elderly women: associations with quantitative bone ultrasound, bone turnover, fractures, and mortality.
J Am Geriatr Soc. 2014; 62(6):1023-1029 Doi: 10.1111/jgs.12791
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** Amrein, K; Schnedl, C; Holl, A; Riedl, R; Christopher, KB; Pachler, C; Urbanic Purkart, T; Waltensdorfer, A; Münch, A; Warnkross, H; Stojakovic, T; Bisping, E; Toller, W; Smolle, KH; Berghold, A; Pieber, TR; Dobnig, H Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial.
JAMA. 2014; 312(15):1520-1530 Doi: 10.1001/jama.2014.13204 [OPEN ACCESS]
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** Brandenburg, VM; Kleber, ME; Vervloet, MG; Tomaschitz, A; Pilz, S; Stojakovic, T; Delgado, G; Grammer, TB; Marx, N; März, W; Scharnagl, H Fibroblast growth factor 23 (FGF23) and mortality: the Ludwigshafen Risk and Cardiovascular Health Study.
Atherosclerosis. 2014; 237(1):53-59 Doi: 10.1016/j.atherosclerosis.2014.08.037
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** Cochet, H; Scherr, D; Zellerhoff, S; Sacher, F; Derval, N; Denis, A; Knecht, S; Komatsu, Y; Montaudon, M; Laurent, F; Pieske, BM; Hocini, M; Haïssaguerre, M; Jaïs, P Atrial structure and function 5 years after successful ablation for persistent atrial fibrillation: an MRI study.
J Cardiovasc Electrophysiol. 2014; 25(7):671-679 Doi: 10.1111/jce.12449
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** Eisenberg, T; Schroeder, S; Andryushkova, A; Pendl, T; Küttner, V; Bhukel, A; Mariño, G; Pietrocola, F; Harger, A; Zimmermann, A; Moustafa, T; Sprenger, A; Jany, E; Büttner, S; Carmona-Gutierrez, D; Ruckenstuhl, C; Ring, J; Reichelt, W; Schimmel, K; Leeb, T; Moser, C; Schatz, S; Kamolz, LP; Magnes, C; Sinner, F; Sedej, S; Fröhlich, KU; Juhasz, G; Pieber, TR; Dengjel, J; Sigrist, SJ; Kroemer, G; Madeo, F Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
Cell Metab. 2014; 19(3):431-444 Doi: 10.1016/j.cmet.2014.02.010 [OPEN ACCESS]
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** Fischer, TH; Eiringhaus, J; Dybkova, N; Förster, A; Herting, J; Kleinwächter, A; Ljubojevic, S; Schmitto, JD; Streckfuß-Bömeke, K; Renner, A; Gummert, J; Hasenfuss, G; Maier, LS; Sossalla, S Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy.
Eur J Heart Fail. 2014; 16(12):1292-1300 Doi: 10.1002/ejhf.163 [OPEN ACCESS]
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** Gheorghiade, M; Vaduganathan, M; Greene, SJ; Mentz, RJ; Adams, KF; Anker, SD; Arnold, M; Baschiera, F; Cleland, JG; Cotter, G; Fonarow, GC; Giordano, C; Metra, M; Misselwitz, F; Mühlhofer, E; Nodari, S; Frank Peacock, W; Pieske, BM; Sabbah, HN; Sato, N; Shah, MR; Stockbridge, NL; Teerlink, JR; van Veldhuisen, DJ; Zalewski, A; Zannad, F; Butler, J Site selection in global clinical trials in patients hospitalized for heart failure: perceived problems and potential solutions.
Heart Fail Rev. 2014; 19(2):135-152 Doi: 10.1007/s10741-012-9361-8 [OPEN ACCESS]
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** Gori, M; Lam, CS; Gupta, DK; Santos, AB; Cheng, S; Shah, AM; Claggett, B; Zile, MR; Kraigher-Krainer, E; Pieske, B; Voors, AA; Packer, M; Bransford, T; Lefkowitz, M; McMurray, JJ; Solomon, SD; PARAMOUNT Investigators Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction.
Eur J Heart Fail. 2014; 16(5):535-542 Doi: 10.1002/ejhf.67 [OPEN ACCESS]
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** Gori, M; Senni, M; Gupta, DK; Charytan, DM; Kraigher-Krainer, E; Pieske, B; Claggett, B; Shah, AM; Santos, AB; Zile, MR; Voors, AA; McMurray, JJ; Packer, M; Bransford, T; Lefkowitz, M; Solomon, SD; PARAMOUNT Investigators Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction.
Eur Heart J. 2014; 35(48):3442-3451 Doi: 10.1093/eurheartj/ehu254 [OPEN ACCESS]
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** Grammer, TB; Kleber, ME; Silbernagel, G; Pilz, S; Scharnagl, H; Lerchbaum, E; Tomaschitz, A; Koenig, W; März, W Copper, ceruloplasmin, and long-term cardiovascular and total mortality (the Ludwigshafen Risk and Cardiovascular Health Study).
Free Radic Res. 2014; 48(6):706-715 Doi: 10.3109/10715762.2014.901510
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** Greene, SJ; Shah, AN; Butler, J; Ambrosy, AP; Anker, SD; Chioncel, O; Collins, SP; Dinh, W; Dunnmon, PM; Fonarow, GC; Lam, CS; Mentz, RJ; Pieske, B; Roessig, L; Rosano, GM; Sato, N; Vaduganathan, M; Gheorghiade, M Designing effective drug and device development programs for hospitalized heart failure: a proposal for pretrial registries.
Am Heart J. 2014; 168(2):142-149 Doi: 10.1016/j.ahj.2014.05.009 [OPEN ACCESS]
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** Grübler, MR; Kienreich, K; Gaksch, M; Verheyen, N; Fahrleitner-Pammer, A; Schmid, J; Grogorenz, J; Ablasser, K; Pieske, B; Tomaschitz, A; Pilz, S Aldosterone to active renin ratio is associated with nocturnal blood pressure in obese and treated hypertensive patients: the Styrian Hypertension Study.
J Clin Hypertens (Greenwich). 2014; 16(4):289-94 Doi: 10.1111/jch.12274 [OPEN ACCESS]
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** Hammer, KP; Hohendanner, F; Blatter, LA; Pieske, BM; Heinzel, FR Variations in local calcium signaling in adjacent cardiac myocytes of the intact mouse heart detected with two-dimensional confocal microscopy.
Front Physiol. 2014; 5(4):517-517 Doi: 10.3389/fphys.2014.00517 [OPEN ACCESS]
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** Jhund, PS; Claggett, B; Packer, M; Zile, MR; Voors, AA; Pieske, B; Lefkowitz, M; Shi, V; Bransford, T; McMurray, JJ; Solomon, SD Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial.
Eur J Heart Fail. 2014; 16(6):671-677 Doi: 10.1002/ejhf.76 [OPEN ACCESS]
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** Jhund, PS; Claggett, BL; Voors, AA; Zile, MR; Packer, M; Pieske, BM; Kraigher-Krainer, E; Shah, AM; Prescott, MF; Shi, V; Lefkowitz, M; McMurray, JJ; Solomon, SD; PARAMOUNT Investigators Elevation in high-sensitivity troponin T in heart failure and preserved ejection fraction and influence of treatment with the angiotensin receptor neprilysin inhibitor LCZ696.
Circ Heart Fail. 2014; 7(6):953-959 Doi: 10.1161/CIRCHEARTFAILURE.114.001427 [OPEN ACCESS]
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** Keeling, IM; Knez, I; Richtig, E; Zweiker, R; Aigelsreiter, A; Dacar, D Cardiac surgery for metastatic melanoma.
Wien Klin Wochenschr. 2014; 126(9-10):261-262 Doi: 10.1007/s00508-014-0518-4 (- Case Report)
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** Kleber, ME; Goliasch, G; Grammer, TB; Pilz, S; Tomaschitz, A; Silbernagel, G; Maurer, G; März, W; Niessner, A Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score.
J Intern Med. 2014; 276(2):184-194 Doi: 10.1111/joim.12189 [OPEN ACCESS]
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** Koller, L; Kleber, M; Goliasch, G; Sulzgruber, P; Scharnagl, H; Silbernagel, G; Grammer, T; Delgado, G; Tomaschitz, A; Pilz, S; März, W; Niessner, A C-reactive protein predicts mortality in patients referred for coronary angiography and symptoms of heart failure with preserved ejection fraction.
Eur J Heart Fail. 2014; 16(7):758-766 Doi: 10.1002/ejhf.104 [OPEN ACCESS]
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** Koyani, CN; Windischhofer, W; Rossmann, C; Jin, G; Kickmaier, S; Heinzel, FR; Groschner, K; Alavian-Ghavanini, A; Sattler, W; Malle, E 15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.
Int J Cardiol. 2014; 173(3):472-480 Doi: 10.1016/j.ijcard.2014.03.086 [OPEN ACCESS]
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** Kraigher-Krainer, E; Shah, AM; Gupta, DK; Santos, A; Claggett, B; Pieske, B; Zile, MR; Voors, AA; Lefkowitz, MP; Packer, M; McMurray, JJ; Solomon, SD; PARAMOUNT Investigators Impaired systolic function by strain imaging in heart failure with preserved ejection fraction.
J Am Coll Cardiol. 2014; 63(5):447-456 Doi: 10.1016/j.jacc.2013.09.052 [OPEN ACCESS]
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** Ljubojevic, S; Radulovic, S; Leitinger, G; Sedej, S; Sacherer, M; Holzer, M; Winkler, C; Pritz, E; Mittler, T; Schmidt, A; Sereinigg, M; Wakula, P; Zissimopoulos, S; Bisping, E; Post, H; Marsche, G; Bossuyt, J; Bers, DM; Kockskämper, J; Pieske, B Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.
Circulation. 2014; 130(3):244-255 Doi: 10.1161/CIRCULATIONAHA.114.008927 [OPEN ACCESS]
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** Lubitz, SA; Lunetta, KL; Lin, H; Arking, DE; Trompet, S; Li, G; Krijthe, BP; Chasman, DI; Barnard, J; Kleber, ME; Dörr, M; Ozaki, K; Smith, AV; Müller-Nurasyid, M; Walter, S; Agarwal, SK; Bis, JC; Brody, JA; Chen, LY; Everett, BM; Ford, I; Franco, OH; Harris, TB; Hofman, A; Kääb, S; Mahida, S; Kathiresan, S; Kubo, M; Launer, LJ; Macfarlane, PW; Magnani, JW; McKnight, B; McManus, DD; Peters, A; Psaty, BM; Rose, LM; Rotter, JI; Silbernagel, G; Smith, JD; Sotoodehnia, N; Stott, DJ; Taylor, KD; Tomaschitz, A; Tsunoda, T; Uitterlinden, AG; Van Wagoner, DR; Völker, U; Völzke, H; Murabito, JM; Sinner, MF; Gudnason, V; Felix, SB; März, W; Chung, M; Albert, CM; Stricker, BH; Tanaka, T; Heckbert, SR; Jukema, JW; Alonso, A; Benjamin, EJ; Ellinor, PT Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese.
J Am Coll Cardiol. 2014; 63(12):1200-1210 Doi: 10.1016/j.jacc.2013.12.015 [OPEN ACCESS]
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** Mader, JK; Neubauer, KM; Schaupp, L; Augustin, T; Beck, P; Spat, S; Höll, B; Treiber, GM; Fruhwald, FM; Pieber, TR; Plank, J Efficacy, usability and sequence of operations of a workflow-integrated algorithm for basal-bolus insulin therapy in hospitalized type 2 diabetes patients.
Diabetes Obes Metab. 2014; 16(2):137-146 Doi: 10.1111/dom.12186 [OPEN ACCESS]
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** Meinitzer, A; Tomaschitz, A; Pilz, S; Truber, M; Zechner, G; Gaksch, M; Prietl, B; Treiber, G; Schwarz, M; Baranyi, A Development of a liquid chromatography-mass spectrometry method for the determination of the neurotoxic quinolinic acid in human serum.
Clin Chim Acta. 2014; 436:268-72 Doi: 10.1016/j.cca.2014.06.010
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** Mileder, LP; Schmidt, A; Dimai, HP Clinicians should be aware of their responsibilities as role models: a case report on the impact of poor role modeling.
Med Educ Online. 2014; 19(2):23479-23479 Doi: 10.3402/meo.v19.23479 [OPEN ACCESS]
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** Nagel, B; Janousek, J; Koestenberger, M; Maier, R; Sauseng, W; Strenger, V; Gamillscheg, A; Zartner, P Remote monitoring leads to early recognition and treatment of critical arrhythmias in adults after atrial switch operation for transposition of the great arteries.
Circ J. 2014; 78(2):450-456 Doi: 10.1253/circj.CJ-13-0670 [OPEN ACCESS]
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** Nagel, B; Maier, R; Kaemmerer, H; Koestenberger, M; Gamillscheg, A; Hess, J; Bogers, AJ; Witsenburg, M; Hofmann, M; Hübler, M How should I treat an adult with unoperated complex cyanotic heart disease with severe pulmonary stenosis?
EuroIntervention. 2014; 10(2):289-292 Doi: 10.4244/EIJV10I2A48 (- Case Report) [OPEN ACCESS]
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** O, Hartaigh, B; Gaksch, M; Kienreich, K; Grübler, MR; Verheyen, N; März, W; Tomaschitz, A; Gill, TM; Pilz, S Associations of daytime, nighttime, and 24-hour heart rate with four distinct markers of inflammation in hypertensive patients: the Styrian Hypertension Study.
J Clin Hypertens (Greenwich). 2014; 16(12):856-61 Doi: 10.1111/jch.12420 [OPEN ACCESS]
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** Pieske, B; Butler, J; Filippatos, G; Lam, C; Maggioni, AP; Ponikowski, P; Shah, S; Solomon, S; Kraigher-Krainer, E; Samano, ET; Scalise, AV; Müller, K; Roessig, L; Gheorghiade, M; SOCRATES Investigators and Coordinators Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES).
Eur J Heart Fail. 2014; 16(9):1026-1038 Doi: 10.1002/ejhf.135 [OPEN ACCESS]
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** Pilz, S; Edelmann, F; Meinitzer, A; Gelbrich, G; Döner, U; Düngen, HD; Tomaschitz, A; Kienreich, K; Gaksch, M; Duvinage, A; Stahrenberg, R; Kunde, J; Schmidt, A; März, W; Wachter, R; Pieske, B Associations of methylarginines and homoarginine with diastolic dysfunction and cardiovascular risk factors in patients with preserved left ventricular ejection fraction.
J Card Fail. 2014; 20(12):923-30 Doi: 10.1016/j.cardfail.2014.09.004
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** Pilz, S; Kienreich, K; Gaksch, M; Grübler, M; Verheyen, N; Bersuch, LA; Schmid, J; Drechsler, C; Ritz, E; Moosbrugger, A; Stepan, V; Pieber, TR; Meinitzer, A; März, W; Tomaschitz, A Aldosterone to active Renin ratio as screening test for primary aldosteronism: reproducibility and influence of orthostasis and salt loading.
Horm Metab Res. 2014; 46(6):427-32 Doi: 10.1055/s-0034-1367033
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** Pilz, S; Teerlink, T; Scheffer, PG; Meinitzer, A; Rutters, F; Tomaschitz, A; Drechsler, C; Kienreich, K; Nijpels, G; Stehouwer, CD; März, W; Dekker, JM Homoarginine and mortality in an older population: the Hoorn study.
Eur J Clin Invest. 2014; 44(2): 200-208 Doi: 10.1111/eci.12208 [OPEN ACCESS]
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** Poelzl, G; Altenberger, J; Pacher, R; Ebner, CH; Wieser, M; Winter, A; Fruhwald, F; Dornaus, C; Ehmsen, U; Reiter, S; Steinacher, R; Huelsmann, M; Eder, V; Boehmer, A; Pilgersdorfer, L; Ablasser, K; Keroe, D; Groebner, H; Auer, J; Jakl, G; Hallas, A; Ess, M; Ulmer, H; Austrian Working Group on Heart Failure Dose matters! Optimisation of guideline adherence is associated with lower mortality in stable patients with chronic heart failure.
Int J Cardiol. 2014; 175(1):83-89 Doi: 10.1016/j.ijcard.2014.04.255
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** Rainer, PP; Hao, S; Vanhoutte, D; Lee, DI; Koitabashi, N; Molkentin, JD; Kass, DA Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction.
Circ Res. 2014; 114(8):1246-1257 Doi: 10.1161/CIRCRESAHA.114.302653 [OPEN ACCESS]
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** Santos, AB; Kraigher-Krainer, E; Gupta, DK; Claggett, B; Zile, MR; Pieske, B; Voors, AA; Lefkowitz, M; Bransford, T; Shi, V; Packer, M; McMurray, JJ; Shah, AM; Solomon, SD; PARAMOUNT Investigators Impaired left atrial function in heart failure with preserved ejection fraction.
Eur J Heart Fail. 2014; 16(10):1096-1103 Doi: 10.1002/ejhf.147 [OPEN ACCESS]
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** Schweiger, M; Klüber, J; Bosch, A; von Levinski, D; Prenner, G; Stiegler, P; Sereinigg, M; Tscheliessnigg, KH; Iberer, F; Wasler, A Low incidence of coronary angiography in the evaluation process of the potential heart donor.
TRANSPL P. 2014; 46(10): 3339-3342. Doi: 10.1016/j.transproceed.2014.06.069
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** Sedej, S; Schmidt, A; Denegri, M; Walther, S; Matovina, M; Arnstein, G; Gutschi, EM; Windhager, I; Ljubojević, S; Negri, S; Heinzel, FR; Bisping, E; Vos, MA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
J Am Coll Cardiol. 2014; 63(15):1569-1579 Doi: 10.1016/j.jacc.2013.11.010 [OPEN ACCESS]
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** Seo, K; Rainer, PP; Lee, DI; Hao, S; Bedja, D; Birnbaumer, L; Cingolani, OH; Kass, DA Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.
Circ Res. 2014; 114(5):823-832 Doi: 10.1161/CIRCRESAHA.114.302614 [OPEN ACCESS]
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** Seo, K; Rainer, PP; Shalkey Hahn, V; Lee, DI; Jo, SH; Andersen, A; Liu, T; Xu, X; Willette, RN; Lepore, JJ; Marino, JP; Birnbaumer, L; Schnackenberg, CG; Kass, DA Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.
Proc Natl Acad Sci U S A. 2014; 111(4):1551-1556 Doi: 10.1073/pnas.1308963111 [OPEN ACCESS]
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** Seppälä, I; Kleber, ME; Lyytikäinen, LP; Hernesniemi, JA; Mäkelä, KM; Oksala, N; Laaksonen, R; Pilz, S; Tomaschitz, A; Silbernagel, G; Boehm, BO; Grammer, TB; Koskinen, T; Juonala, M; Hutri-Kähönen, N; Alfthan, G; Viikari, JS; Kähonen, M; Raitakari, OT; März, W; Meinitzer, A; Lehtimäki, T; AtheroRemo Consortium Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
Eur Heart J. 2014; 35(8):524-531 Doi: 10.1093/eurheartj/eht447 [OPEN ACCESS]
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** Sliwa, K; Hilfiker-Kleiner, D; Mebazaa, A; Petrie, MC; Maggioni, AP; Regitz-Zagrosek, V; Schaufelberger, M; Tavazzi, L; van Veldhuisen, DJ; Roos-Hesslink, JW; Shah, AJ; Seferovic, PM; Elkayam, U; van Spaendonck-Zwarts, K; Bachelier-Walenta, K; Mouquet, F; Kraigher-Krainer, E; Hall, R; Ponikowski, P; McMurray, JJ; Pieske, B EURObservational Research Programme: a worldwide registry on peripartum cardiomyopathy (PPCM) in conjunction with the Heart Failure Association of the European Society of Cardiology Working Group on PPCM.
Eur J Heart Fail. 2014; 16(5):583-591 Doi: 10.1002/ejhf.68 [OPEN ACCESS]
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** Suchy, C; Massen, L; Rognmo, O; Van Craenenbroeck, EM; Beckers, P; Kraigher-Krainer, E; Linke, A; Adams, V; Wisløff, U; Pieske, B; Halle, M Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial.
Eur J Prev Cardiol. 2014; 21(2 Suppl):18-25 Doi: 10.1177/2047487314552764
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** Tomaschitz, A; Meinitzer, A; Pilz, S; Rus-Machan, J; Genser, B; Drechsler, C; Grammer, T; Krane, V; Ritz, E; Kleber, ME; Pieske, B; Kraigher-Krainer, E; Fahrleitner-Pammer, A; Wanner, C; Boehm, BO; März, W Homoarginine, kidney function and cardiovascular mortality risk.
Nephrol Dial Transplant. 2014; 29(3):663-671 Doi: 10.1093/ndt/gft512 [OPEN ACCESS]
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** Toth, GG; Toth, B; Johnson, NP; De Vroey, F; Di Serafino, L; Pyxaras, S; Rusinaru, D; Di Gioia, G; Pellicano, M; Barbato, E; Van Mieghem, C; Heyndrickx, GR; De Bruyne, B; Wijns, W Revascularization decisions in patients with stable angina and intermediate lesions: results of the international survey on interventional strategy.
Circ Cardiovasc Interv. 2014; 7(6):751-759 Doi: 10.1161/CIRCINTERVENTIONS.114.001608 [OPEN ACCESS]
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** Vidal-Pérez, R; Fontes-Carvalho, R; Gargani, L; Jankowska, E; Pazdernik, M; Pöss, J; Wallner, M; Zuily, S The Cardiostars Project: inspiring the next generation of cardiologists.
Eur Heart J. 2014; 35(15): 944-945. [OPEN ACCESS]
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** Walther, S; Pluteanu, F; Renz, S; Nikonova, Y; Maxwell, JT; Yang, LZ; Schmidt, K; Edwards, JN; Wakula, P; Groschner, K; Maier, LS; Spiess, J; Blatter, LA; Pieske, B; Kockskämper, J Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177.
Am J Physiol Heart Circ Physiol. 2014; 307(5):H689-H700 Doi: 10.1152/ajpheart.00694.2013 [OPEN ACCESS]
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Kurzbericht/Letter

** Zweiker, D; Maier, R; Lamm, G; Maurer, E; Heigert, M; Neunteufl, T; Zeindlhofer, E; Grund, M; Aichinger, J; Huber, K; Schneider, J; Pollak, J; Luha, O; Zweiker, R; Austrian Society of Cardiology, Committee on Interventional Cardiology The Austrian transcatheter aortic valve implantation (TAVI) Registry--3 years' data.
Int J Cardiol. 2014; 177(1):114-116 Doi: 10.1016/j.ijcard.2014.09.096
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Übersichtsarbeit

** Bisping, E; Wakula, P; Poteser, M; Heinzel, FR Targeting cardiac hypertrophy: toward a causal heart failure therapy.
J Cardiovasc Pharmacol. 2014; 64(4):293-305 Doi: 10.1097/FJC.0000000000000126 [OPEN ACCESS]
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** Corrà, U; Piepoli, MF; Adamopoulos, S; Agostoni, P; Coats, AJ; Conraads, V; Lambrinou, E; Pieske, B; Piotrowicz, E; Schmid, JP; Seferović, PM; Anker, SD; Filippatos, G; Ponikowski, PP Cardiopulmonary exercise testing in systolic heart failure in 2014: the evolving prognostic role: a position paper from the committee on exercise physiology and training of the heart failure association of the ESC.
Eur J Heart Fail. 2014; 16(9):929-941 Doi: 10.1002/ejhf.156 [OPEN ACCESS]
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** Heschl, S; Colantonio, C; Pieske, B; Toller, W Perioperative care of patients with diastolic heart failure. Interface to anesthesia].
Anaesthesist. 2014; 63(12):951-957 Doi: 10.1007/s00101-014-2404-x
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** Ritz, E; Tomaschitz, A Aldosterone and the kidney: a rapidly moving frontier (an update).
Nephrol Dial Transplant. 2014; 29(11):2012-2019 Doi: 10.1093/ndt/gft035 [OPEN ACCESS]
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** Rossi, A; Gheorghiade, M; Triposkiadis, F; Solomon, SD; Pieske, B; Butler, J Left atrium in heart failure with preserved ejection fraction: structure, function, and significance.
Circ Heart Fail. 2014; 7(6):1042-1049 Doi: 10.1161/CIRCHEARTFAILURE.114.001276 [OPEN ACCESS]
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** Senni, M; Paulus, WJ; Gavazzi, A; Fraser, AG; Díez, J; Solomon, SD; Smiseth, OA; Guazzi, M; Lam, CS; Maggioni, AP; Tschöpe, C; Metra, M; Hummel, SL; Edelmann, F; Ambrosio, G; Stewart Coats, AJ; Filippatos, GS; Gheorghiade, M; Anker, SD; Levy, D; Pfeffer, MA; Stough, WG; Pieske, BM New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes.
Eur Heart J. 2014; 35(40):2797-2815 Doi: 10.1093/eurheartj/ehu204 [OPEN ACCESS]
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** Tomaschitz, A; Ritz, E; Pieske, B; Rus-Machan, J; Kienreich, K; Verheyen, N; Gaksch, M; Grübler, M; Fahrleitner-Pammer, A; Mrak, P; Toplak, H; Kraigher-Krainer, E; März, W; Pilz, S Aldosterone and parathyroid hormone interactions as mediators of metabolic and cardiovascular disease.
Metabolism. 2014; 63(1):20-31 Doi: 10.1016/j.metabol.2013.08.016 [OPEN ACCESS]
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Editorial

** Lam, CS; Pieske, B Heart failure with preserved ejection fraction(HFPEF) currently represents one of the greatest unmet needs in Cardiology. Introduction.
Heart Fail Clin. 2014; 10(3):xv-xv Doi: 10.1016/j.hfc.2014.05.002
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Fallbericht

** Reiter, U; Reiter, G; Asslaber, M; Dacar, D; Maderthaner, R; Binder, J; Greiser, A; Beer, M; Fuchsjäger, M Characterization of a calcified intra-cardiac pseudocyst of the mitral valve by magnetic resonance imaging including T1 and T2 mapping.
BMC Cardiovasc Disord. 2014; 14:11 Doi: 10.1186/1471-2261-14-11 (- Case Report) [OPEN ACCESS]
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Korrespondenz

** Koyani, CN; Windischhofer, W; Rossmann, C; Heinzel, FR; Sattler, W; Malle, E Response to letter by Tsikas et al.
INT J CARDIOL. 2014; 177(1): 140-141. Doi: 10.1016/j.ijcard.2014.09.111
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Abstract (Zeitschrift)

** Albus, C; Beutel, M; Deter, HC; Fritzsche, K; Hellmich, M; Jordan, J; Junger, J; Ladwig, KH; Michal, M; Petrowski, K; Pieske, B; Ronel, J; Sollner, W; Stohr, A; Weber, CS; Wiltink, J; de Zwaan, M; Herrmann-Lingen, C RATIONALE, DESIGN AND BASELINE DATA OF THE SPIRR-CAD TRIAL
PSYCHOSOM MED. . 2014; 76(3):A20-A20.-72nd Annual Meeting of the American-Psychosomatic-Society; MAR 12-15, 2014; San Francisco, CA. [Poster]
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** Alesutan, I; Voelkl, J; Stoeckigt, F; Primessnig, U; Mia, S; Sopjani, M; Feger, M; Munoz, C; Borst, O; Gawaz, M; Metzler, B; Schrickel, J; Heinzel, F; Lang, F Ampk alpha 1 deficiency ameliorates cardiac dysfunction following pressure overload
ACTA PHYSIOL. . 2014; 210: 92-92. [Poster]
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** Alogna, A; Schwarzl, M; Zirngast, B; Manninger-Wuenscher, M; Vederber, J; Zweiker, D; Steendijk, P; Maechler, H; Pieske, B; Post, H Haemodynamic effects of acute PDE-5A inhibition in a porcine model of hypertensive heart disease.
EUR J HEART FAIL. 2014; 16: 202-202. [Poster]
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** Alogna, A; Schwarzl, M; Zirngast, B; Manninger-Wuenscher, M; Zweiker, D; Verderber, J; Steendijk, P; Maechler, H; Pieske, B; Post, H Haemodynamic effects of acute stimulation of soluble guanylate cyclase in a porcine model of hypertensive heart disease.
EUR J HEART FAIL. 2014; 16: 201-202. [Poster]
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** Belyavskiy, E; Kraigher-Krainer, E; Url-Michitsch, M; Kapl, M; Schmidt, A; Pieske, B; Diastolic stress test and new imaging modalities in detection of impaired systolic and diastolic function in patients with hypertensive heart disease and heart failure with preserved ejection fraction.
EUR J HEART FAIL. . 2014; 16: 92-92. [Poster]
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** Dechend, R; Mueller, DN; Heidecke, H; Busjahn, A; Wachter, R; Riemekasten, G; Tahirovic, E; Pieske, B; Trippel, TD; Duengen, HD Heart Failure and autoantibodies against the beta1 adrenoreceptor
EUR HEART J. . 2014; 35: 722-722.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Dechend, R; Mueller, DN; Heidecke, HD; Busjahn, A; Dragun, DN; Pieske, B; Riemekasten, G; Tahirovic, E; Trippel, TD; Duengen, HD; Autoantibodies against the Thrombin receptor (PAR-1) are substantially reduced in patients with heart failure: results from the CIBIS-ELD trial.
EUR J HEART FAIL. . 2014; 16: 216-216. [Poster]
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** Delgado, G; Drechsler, C; Wanner, C; Blouin, K; Pilz, S; Tomaschitz, A; Kleber, ME; Willmes, C; Krane, V; Marz, W; Ritz, E; Van Gilst, WH; Van der Harst, P; De Boer, RA GALECTIN-3 AND ADVERSE OUTCOMES IN CHRONIC KIDNEY DISEASE - RESULTS FROM THE LURIC AND THE 4D STUDY
NEPHROL DIAL TRANSPL. 2014; 29: 120-120.-51st Congress of the European-Renal-Association(ERA)/European-Dialysis-and-Transplant-Association (EDTA); MAY 31-JUN 03, 2014; Amsterdam, NETHERLANDS. [Poster]
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** Drechsler, C; Philstrom, H; Meinitzer, A; Pilz, S; Tomaschitz, A; Abedini, S; Fellstrom, B; Jardine, A; Wanner, C; Maerz, W; Holdaas, H HOMOARGININE AND CLINICAL OUTCOMES IN RENAL TRANSPLANT RECIPIENTS: RESULTS FROM THE ALERT STUDY
NEPHROL DIAL TRANSPL. 2014; 29: 539-539.-51st Congress of the European-Renal-Association(ERA)/European-Dialysis-and-Transplant-Association (EDTA); MAY 31-JUN 03, 2014; Amsterdam, NETHERLANDS. [Poster]
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** Duengen, HD; Trippel, TD; Tahirovic, E; Mueller, DN; Wilck, N; Wachter, R; Busjahn, A; Heidecke, H; Pieske, B; Dechend, R; Autoantibodies against the beta1 adrenoreceptor detected by ELISA in chronic heart failure patients.
EUR J HEART FAIL. . 2014; 16: 216-216. [Poster]
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** Duengen, HD; Trippel, TD; Tahirovic, E; Mueller, DN; Wilck, N; Wachter, R; Heidecke, H; Busjahn, A; Pieske, B; Dechend, R Heart failure and the soluble prorenin receptor (sPRR): results from the CIBIS-ELD trial
EUR HEART J. . 2014; 35: 667-668.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Goliasch, G; Kleber, M; Grammer, TB; Pilz, S; Tomaschitz, A; Silbernagel, G; Maurer, G; Marz, W; Alexander, N EVOLVING BIOMARKERS IMPROVE PREDICTION OF LONG-TERM MORTALITY IN PATIENTS WITH STABLE CAD: THE BIO-VILCAD SCORE
J AM COLL CARDIOL. 2014; 63(12):A1390-A1390. Doi: 10.1016/S0735-1097(14)61390-5 [Poster]
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** Grammer, TB; Kleber, M; Maerz, W; Silbernagel, G; Siekmeier, R; Pilz, S; Tomaschitz, A; Konig, W; Scharnagl, H Particle Diameter in the Low Density Lipoprotein as Mortality Factor- Results from Ludwigshafen Risk and Cardiovascular Health Study(LURIC)
WIEN KLIN WOCHENSCHR. 2014; 126: S133-S134.
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** Grubler, MR; Verheyen, N; Gaksch, M; Kienreich, K; Oberreither, E; Schmid, J; Pieske, B; Tomaschitz, A; Pilz, S; Maerz, W Parathyroid hormone is associated with cardiovascular mortality in patients with acute coronary syndrome
EUR HEART J. 2014; 35: 1157-1157.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Herrmann-Lingen, C; Beutel, M; Boese, A; Deter, HC; Fritzsche, K; Hellmich, M; Jordan, J; Junger, J; Ladwig, KH; Michal, M; Petrowski, K; Pieske, B; Ronel, J; Sollner, W; Stohr, A; Weber, CS; Wiltink, J; de Zwaan, M; Albus, C A STEPWISE PSYCHOTHERAPY INTERVENTION TO REDUCE RISK IN CORONARY ARTERY DISEASE (SPIRR-CAD) FIRST RESULTS OF A LARGE RANDOMIZED MULTICENTER TRIAL
PSYCHOSOM MED. . 2014; 76(3):A20-A20.-72nd Annual Meeting of the American-Psychosomatic-Society; MAR 12-15, 2014; San Francisco, CA. [Poster]
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** Jhund, PS; Claggett, BL; Shah, A; Voors, AA; Zile, MR; Packer, M; Pieske, B; Prescott, MF; Mcmurray, JJV; Solomon, SD High prevalence of elevated high sensitivity troponin-T and reduction in levels by LCZ696 in heart failure with preserved ejection fraction in the PARAMOUNT trial
EUR HEART J. . 2014; 35: 1036-1036.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Jhund, PS; Claggett, BL; Zile, MR; Shah, A; Voors, AA; Packer, M; Pieske, B; Prescott, MF; Mcmurray, JJV; Solomon, SD Soluble ST2 is associated with markers of diastolic dysfunction in patients with heart failure with preserved ejection fraction in the PARAMOUNT trial
EUR HEART J. . 2014; 35: 340-341.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Kielhauser, SM; Moazedi-Fuerst, FC; Hermann, J; Gretler, J; Brickmann, K; Lutfi, A; Kovacs, G; Schmid, J; Binder, J; Graninger, WB B cell depletion therapy in a patient with systemic sclerosis improves parameters of skin, lung and heart involvement
WIEN KLIN WOCHENSCHR. 2014; 126: -ÖGR Jahrestagung; Nov 25- Nov 27, 2014; Vienna, 2014. [Poster]
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** Ljubojevic, S; Radulovic, S; Sedej, S; Kockskaemper, J; Pieske, B; Alterations of Nuclear Ca2+- Dependent Signalling in Heart Failure.
BIOPHYS J. 2014; 106(2):115A-115A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.698 [Poster]
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** Luers, C; Edelmann, F; Wachter, R; Pieske, B; Mende, M; Angermann, C; Ertl, G; Duengen, HD; Stoerk, S Prognostic impact of diastolic dysfunction in patients with heart failure with reduced ejection fraction: a cross-sectional analysis from the German Competence Network Heart Failure
EUR HEART J. . 2014; 35: 1036-1036.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Manninger-Wuenscher, M; Alogna, A; Zweiker, D; Verderber, J; Reiter, S; Zirngast, B; Pieske, BM; Post, H; Scherr, D Mild hypothermia increases the inducibility of atrial fibrillation in healthy pigs
EUR HEART J. 2014; 35: 824-824.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Pieske, B; Butler, J; Filippatos, G; Lam, C; Maggioni, A; Ponikowski, P; Shah, S; Solomon, S; Roessig, L; Gheorghiade, M; Design and Rationale of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES).
EUR J HEART FAIL. . 2014; 16: 95-95. [Poster]
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** Pieske, B; Butler, J; Filippatos, G; Lam, CSP; Maggioni, AP; Ponikowski, P; Shah, SJ; Solomon, SD; Kraigher-Krainer, E; Samano, ET; Scalise, AV; Muller, K; Roessig, L; Gheorghiade, M Design and Rationale of the Soluble Guanylate Cyclase Stimulator in Heart Failure Studies (SOCRATES)
J CARD FAIL. . 2014; 20(8):S39-S39.-18th Annual Scientific Meeting of the Heart-Failure-Society-of-America (HFSA); SEP 14-17, 2014; Las Vegas, NV. Doi: 10.1016/j.cardfail.2014.06.112 [Poster]
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** Poteser, M; Doleschal, B; Schernthaner, M; Schleifer, H; Tieber, K; Frischauf, I; Romanain, C; Groschner, K; TRPC3 Modulates Association of Orai1 with Immunophilin FKBP12 and Orai-Mediated Ca2+-Transcription Coupling in Mast Cells.
BIOPHYS J. 2014; 106(2):755A-755A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.4155 [Poster]
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** Primessnig, U; Hoell, A; Pfeiffer, S; Bracic, T; Rau, T; Wakula, P; Pieske, BM; Heinzel, FR Diastolic Ca2+leak and the role of the Na+/Ca2+exchanger (NCX) in a model of heart failure with preserved ejection fraction
EUR HEART J. . 2014; 35: 162-162.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Primessnig, U; Hoell, A; Pfeiffer, S; Rau, T; Wakula, P; Pieske, B; Heinzel, F Inhibition of the NA(+)/CA(2+) Exchanger (Ncx) Improves Cardiomyocyte Contractile Dysfunction in a Rat Model with Compensated Renal Failure and Heart Failure with Preserved Ejection Fraction
BIOPHYS J. 2014; 106(2): 115A-115A. Doi: 10.1016/j.bpj.2013.11.697 [Poster]
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** Primessnig, U; Hoell, A; Pfeiffer, S; Rau, T; Wakula, P; Pieske, BM; Heinzel, FR; HFWM: Na+/Ca2+exchanger (NCX) blockade improves cardiomyocyte function in a rat model with heart failure with preserved ejection fraction.
EUR J HEART FAIL. . 2014; 16: 101-101. [Poster]
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** Primessnig, U; Hoell, A; Wakula, P; Pieske, BM; Heinzel, FR Na+/Ca2+exchanger (NCX) function and diastolic Ca2+leak in a model of heart failure with preserved ejection fraction
CARDIOVASC RES. 2014; 103: Doi: 10.1093/cvr/cvu098.104 [Poster]
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** Ribitsch, A; Mader, JK; Köhler, G; von Lewinski, D; Pieber, TR; Treiber, G Gute Genesung nach Diabetes Typ 1 Manifestation mit schwerer Ketoazidose, Insult, Rhabdomyolyse, akutem Nierenversagen und septischem Schock.
Wiener Klinische Wochenschrift. 2014; 126(S04):S178-S178.-42. Jahrestagung der Österreichischen Diabetes Gesellschaft (ÖDG); NOV 20-22, 2014; Salzburg, AUSTRIA. [Poster]
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** Schulz, E; Kashofer, K; Mhatre, KN; Höfler, G; Sill, H SELECTION OF A PRE-EXISTING TP53 MUTATED CLONE IN THERAPY-RELATED ACUTE MYELOID LEUKEMIA
Haematologica. 2014; 99(S1):15-15.-19th Congress of the European Hematology Association; JUNE 12-15, 2014; Milan, ITALY. [Poster]
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** Schwarzl, M; Alogna, A; Zirngast, B; Steendijk, P; Maechler, H; Pieske, BM; Post, H; The soluble guanylate cyclase (sGC) stimulator BAY 41-8543 exerts a negative inotropic effect in healthy pigs.
EUR J HEART FAIL. 2014; 16: 108-108. [Keynote lecture]
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** Schwarzl, M; Alogna, A; Zirngast, B; Steendijk, P; Maechler, H; Pieske, BM; Post, H; Apelin has no effect on left ventricular inotropy in healthy closed-chest pigs.
EUR J HEART FAIL. 2014; 16: 221-221. [Poster]
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** Schwarzl, M; Alogna, A; Zirngast, B; Steendijk, P; Maechler, H; Pieske, BM; Post, H; The inotropic effect of mild hypothermia exceeds the force-frequency relationship in healthy pigs.
EUR J HEART FAIL. . 2014; 16: 108-109. [Poster]
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** Sedej, S; Matovina, M; Schmidt, A; Ljubojevic, S; Heinzel, FR; Negri, S; Napolitano, C; Vos, MA; Priori, SG; Pieske, B Reduced pressure overload-induced myocardial remodeling in K201-treated mice with the R4496C cardiac ryanodine receptor mutation
CARDIOVASC RES. 2014; 103: -3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology; JUL 04-06, 2014; Barcelona, SPAIN. Doi: 10.1093/cvr/cvu091.70 [Poster]
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** Trippel, TD; Duengen, HD; Binger, K; Maschke, U; Heidecke, H; Busjahn, A; Wachter, R; Pieske, B; Mueller, DN; Dechend, R Reduced level of thrombin receptor (PAR-1) autoantibodies in chronic heart failure: new insights?
EUR HEART J. . 2014; 35: 669-669.-Congress of the European-Society-of-Cardiology (ESC); AUG 30-SEP 03, 2014; Barcelona, SPAIN. [Poster]
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** Trippel, TD; Obradovic, D; Duengen, HD; Maschke, U; Binger, K; Busjahn, A; Pieske, B; Heidecke, H; Mueller, DN; Dechend, R; Soluble prorenin receptor (sPRR) in chronic heart failure patients.
EUR J HEART FAIL. . 2014; 16: 320-320. [Poster]
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** Vardeny, O; Skali, H; Jhund, P; Claggett, B; Shah, AM; Zile, MR; Voors, AA; Pieske, B; Packer, M; Lefkowitz, MP; Shi, V; McMurray, JJV; Solomon, SD Influence of Diabetes Mellitus on Cardiac Structure and Function and Response to Therapy with LCZ696 in Heart Failure with Preserved Ejection Fraction
J CARD FAIL. . 2014; 20(8):S40-S40.-18th Annual Scientific Meeting of the Heart-Failure-Society-of-America (HFSA); SEP 14-17, 2014; Las Vegas, NV. Doi: 10.1016/j.cardfail.2014.06.114 [Poster]
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** Volkl, J; Alesutan, I; Stoeckigt, F; Primessnig, U; Mia, S; Sopjani, M; Feger, M; Munoz, C; Borst, O; Gawaz, M; Metzler, B; Schrickel, J; Heinzel, F; Lang, F Ampk alpha 1 deficiency counteracts gap junction remodelling following pressure overload
ACTA PHYSIOL. . 2014; 210: 90-90. [Poster]
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** Wakula, P; Antoons, G; Radulovic, S; Ljubojevic, S; Sereinigg, M; Pieske, BM; Heinzel, FR; Wnt-11 Signaling in Cardiomyocytes.
BIOPHYS J. 2014; 106(2):115A-115A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.696 [Poster]
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** Walther, S; Edwards, JN; Pluteanu, F; Renz, S; Schmidt, K; Pieske, B; Kockskaemper, J; Blatter, LA; Urocortin 2 Protects Against Pacing-Induced Alternans via Phosphorylation of Phospholamban in Cardiac Myocytes from Normal and Failing Hearts.
BIOPHYS J. . 2014; 106(2):116A-116A.-58th Annual Meeting of the Biophysical-Society; FEB 15-19, 2014; San Francisco, CA. Doi: 10.1016/j.bpj.2013.11.699 [Poster]
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Kommentar

** Eisenberg, T; Schroeder, S; Büttner, S; Carmona-Gutierrez, D; Pendl, T; Andryushkova, A; Mariño, G; Pietrocola, F; Harger, A; Zimmermann, A; Magnes, C; Sinner, F; Sedej, S; Pieber, TR; Dengjel, J; Sigrist, S; Kroemer, G; Madeo, F A histone point mutation that switches on autophagy.
Autophagy. 2014; 10(6):1143-1145 Doi: 10.4161/auto.28767 [OPEN ACCESS]
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** Ohler, A; Post, H; Schmidt-Schweda, S; Pieske, B Reply to letter: Is hypothermia beneficial even for the depressed heart after the resumption of spontaneous circulation (ROSC) from out-of-hospital cardiac arrest (OHCA)?
RESUSCITATION. 2014; 85(6): e95-e96. Doi: 10.1016/j.resuscitation.2014.02.029
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** Pilz, S; Gaksch, M; Tomaschitz, A Vitamin D and prevention of diabetes: is lifelong endogenous vitamin D needed?
Lancet Diabetes Endocrinol. 2014; 2(4):267-268 Doi: 10.1016/S2213-8587(13)70220-1
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** Scherr, D; Jais, P Atrial fibrillation: AF prognosis and treatment--the European perspective.
Nat Rev Cardiol. 2014; 11(12):689-690 Doi: 10.1038/nrcardio.2014.171
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** Tomaschitz, A; Pilz, S Interplay between sodium and calcium regulatory hormones: a clinically relevant research field.
Hypertension. 2014; 63(2): 212-214. Doi: 10.1161/HYPERTENSIONAHA.113.02253 [OPEN ACCESS]
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